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1.发明授权Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders 有权定向序列聚合物组合物及其抗体的合成用于治疗蛋白质构象障碍公开(公告)号：US08546532B2
公开(公告)日：2013-10-01
申请号：US12386493
申请日：2009-04-17
Applicant: Dustan Bonnin , Eric Zanelli , Thomas Mathers
Inventor： Dustan Bonnin , Eric Zanelli , Thomas Mathers
Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
Abstract translation: 本发明包括用于固相合成可用于治疗和诊断蛋白质构象障碍的定向表位肽混合物的方法，该方法由关于代替碱基的氨基酸的身份和发生频率的一组规则定义 或已知表位的天然氨基酸。 所得组合物是用于治疗用途的相关肽的混合物。 本发明还涉及使用定向表位肽混合物作为抗原产生抗体的方法，以及由该方法产生的抗体可用于治疗和诊断所述蛋白质构象障碍。
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公开(公告)号：US08475779B2
公开(公告)日：2013-07-02
申请号：US12637723
申请日：2009-12-14
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC classification number: A61K38/02 , A61K38/16 , A61K2300/00
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
Abstract translation: 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20080194462A1
公开(公告)日：2008-08-14
申请号：US10591315
申请日：2005-09-15
Applicant: Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
Inventor： Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
IPC: A61K38/28 , A61K38/16 , G01N33/566 , A61P3/10 , A61P37/00
CPC classification number: A61K38/02
Abstract: The present invention provides methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses. The copolymers are random copolymers of amino acids and copolymers comprising anchor residues to facilitate binding to the DQ binding pockets.
Abstract translation: 本发明提供用于治疗自身免疫性疾病和其他不需要的免疫反应的方法和组合物，其包括施用与一种或多种HLA-DQ分子结合并调节DQ限制性T细胞应答的共聚物。 共聚物是氨基酸的无规共聚物和包含锚定残基的共聚物，以便于结合DQ结合袋。
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公开(公告)号：US20060194725A1
公开(公告)日：2006-08-31
申请号：US11283405
申请日：2005-11-17
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC: A61K38/17
CPC classification number: C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
Abstract translation: 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20060189527A1
公开(公告)日：2006-08-24
申请号：US11283406
申请日：2005-11-17
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
IPC: A61K38/16
CPC classification number: A61K38/02 , A61K38/16 , A61K2300/00
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
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Patent Agency Ranking
6.发明申请Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes 有权通过定向扩增表位设计和制备包含定向序列聚合物组合物的疫苗的方法公开(公告)号：US20110129497A1
公开(公告)日：2011-06-02
申请号：US12288345
申请日：2008-10-16
Applicant: Dustan Bonnin , Eric Zanelli , Jeff Krieger , Thomas Mathers
Inventor： Dustan Bonnin , Eric Zanelli , Jeff Krieger , Thomas Mathers
IPC: A61K39/145 , C07K1/107 , A61K39/00 , A61K39/12 , A61K39/02 , A61P31/16 , A61P31/12 , A61P31/04 , A61P33/00 , A61P37/04
CPC classification number: A61K39/145 , A61K39/00 , A61K39/12 , C07K1/047 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/388 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466 , Y02A50/472 , Y02A50/48 , Y02A50/484
Abstract: The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.
Abstract translation: 本发明包括制备包含定向序列聚合物（DSP）混合物的组合物的方法，所述定向序列聚合物（DSP）混合物用作表位并且可用作疫苗，根据关于代替氨基酸的同一性和发生频率的一组规则合成的DSP 碱或天然氨基酸。 所得组合物是用于治疗用作疫苗的相关肽的混合物，优选用于免疫逃避的感染因子。
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公开(公告)号：US20100316714A1
公开(公告)日：2010-12-16
申请号：US12637723
申请日：2009-12-14
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC classification number: A61K38/02 , A61K38/16 , A61K2300/00
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
Abstract translation: 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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8.发明申请Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods 审中-公开组织样本中复杂肽混合物的有效定量和改进的治疗方法公开(公告)号：US20090275496A1
公开(公告)日：2009-11-05
申请号：US12316297
申请日：2008-12-10
Applicant: Sam Baldwin , Dustan Bonnin , Keith Johnson , Jeff Krieger , James Rasmussen , Bei Yu , Eric Zanelli , Jianxin Zhang , Kathryn H. Collins , Michelle Genova , Joseph Kovalchin
Inventor： Sam Baldwin , Dustan Bonnin , Keith Johnson , Jeff Krieger , James Rasmussen , Bei Yu , Eric Zanelli , Jianxin Zhang , Kathryn H. Collins , Michelle Genova , Joseph Kovalchin
CPC classification number: A61K31/785 , A61K9/0019 , A61K38/07 , A61K38/16 , C07K5/101 , C07K5/1016 , G01N33/564 , G01N33/6842
Abstract: The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation.
Abstract translation: 本发明提供了检测和定量组织样品中复合肽混合物的方法以及这种复合肽混合物施用结果的功能性读出方法。 本发明还提供了向有需要的受试者施用复合肽混合物的方法，基于上述检测和定量方法确定的剂量方案和量。
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9.发明授权HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis 失效对HLA-DQ分子具有特异性结合亲和力的HLA-DRBI肽：预防和治疗类风湿性关节炎
公开(公告)号：US5965787A
公开(公告)日：1999-10-12
申请号：US521871
申请日：1995-08-31
Applicant: Harvinder S. Luthra , Chella S. David , Eric Zanelli
Inventor： Harvinder S. Luthra , Chella S. David , Eric Zanelli
IPC: A01K67/027 , A61K38/00 , A61P19/02 , C07K14/74 , C12N15/12 , C12N15/85 , C12N15/63 , C12N5/10 , C12N15/09
CPC classification number: C12N15/8509 , A01K67/0275 , A01K67/0276 , C07K14/70539 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2267/0325 , A61K38/00
Abstract: Disclosed are transgenic mice carrying a human HLA-DQ sgene. The transgenic mice are deficient in mouse H-2 class II molecules. Such mice provide animal model systems to identify peptides useful for preventing or treating rheumatoid arthritis. Also disclosed are methods and materials for treating rheumatoid arthritis, including administration of peptides having specific binding affinity for HLA-DQ molecules expressed in a rheumatoid arthritis patient.
Abstract translation: 公开了携带人HLA-DQ基因的转基因小鼠。 转基因小鼠缺乏小鼠H-2 II类分子。 这样的小鼠提供动物模型系统来鉴定可用于预防或治疗类风湿性关节炎的肽。 还公开了用于治疗类风湿性关节炎的方法和材料，包括给予在类风湿性关节炎患者中表达的HLA-DQ分子具有特异性结合亲和力的肽。
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10.发明授权Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes 有权通过定向扩增表位设计和制备包含定向序列聚合物组合物的疫苗的方法公开(公告)号：US09533037B2
公开(公告)日：2017-01-03
申请号：US12288345
申请日：2008-10-16
Applicant: Dustan Bonnin , Eric Zanelli , Jeff Krieger , Thomas Mathers
Inventor： Dustan Bonnin , Eric Zanelli , Jeff Krieger , Thomas Mathers
IPC: A61K39/145 , A61K39/12 , C07K14/005 , A61K39/00 , C07K1/04
CPC classification number: A61K39/145 , A61K39/00 , A61K39/12 , C07K1/047 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/388 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466 , Y02A50/472 , Y02A50/48 , Y02A50/484
Abstract: The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.
Abstract translation: 本发明包括制备包含定向序列聚合物（DSP）混合物的组合物的方法，所述定向序列聚合物（DSP）混合物用作表位并且可用作疫苗，根据关于代替氨基酸的同一性和发生频率的一组规则合成的DSP 碱或天然氨基酸。 所得组合物是用于治疗用作疫苗的相关肽的混合物，优选用于免疫逃避的感染因子。
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