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    TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS
    2.
    发明申请
    TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS 审中-公开
    用共聚物1和相关共聚物处理自动调节条件

    公开(公告)号：US20150030560A1

    公开(公告)日：2015-01-29

    申请号：US14188531

    申请日：2014-02-24

    申请人： Rina Aharoni ,  Dvora Teitelbaum ,  Ruth Arnon ,  Michael Sela ,  Masha Fridkis-Hareli ,  Jack L. Strominger

    发明人： Rina Aharoni ,  Dvora Teitelbaum ,  Ruth Arnon ,  Michael Sela ,  Masha Fridkis-Hareli ,  Jack L. Strominger

    IPC分类号： A61K31/785 ,  C08G73/02

    CPC分类号： A61K31/785 ,  A61K38/16 ,  C08G73/02 ,  G01N33/6842 ,  Y10S424/81 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/903

    摘要： The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.

    摘要翻译： 本发明涉及含有以线性阵列随机连接的至少三个氨基酸的多肽; 其中所述三个氨基酸中的至少一个是芳族氨基酸，所述三个氨基酸中的至少一个是带电荷的氨基酸，并且至少一个氨基酸是脂族氨基酸。 在优选的实施方案中，多肽含有三个或四个以下氨基酸：酪氨酸，丙氨酸，谷氨酸或赖氨酸。 根据本发明，本发明的多肽与抗原呈递细胞，纯化的人淋巴细胞抗原（HLA）和/或共聚物1-特异性T细胞结合。 此外，根据本发明，这些多肽可以配制成用于治疗自身免疫疾病的药物组合物。 本发明进一步考虑了通过向哺乳动物施用药学上有效量的本发明多肽的任何一种来治疗哺乳动物自身免疫性疾病的方法。

    Molecular recognition at surfaces derivatized with self-assembled monolayers
    6.
    发明授权
    Molecular recognition at surfaces derivatized with self-assembled monolayers 失效
    用自组装单层衍生的表面的分子识别

    公开(公告)号：US5620850A

    公开(公告)日：1997-04-15

    申请号：US312388

    申请日：1994-09-26

    申请人： Cynthia C. Bamdad ,  George B. Sigal ,  Jack L. Strominger ,  George M. Whitesides

    发明人： Cynthia C. Bamdad ,  George B. Sigal ,  Jack L. Strominger ,  George M. Whitesides

    IPC分类号： C12Q1/68 ,  G01N33/543 ,  C07K2/00 ,  C07K5/00 ,  G01N33/53

    CPC分类号： B82Y30/00 ,  B82Y15/00 ,  B82Y40/00 ,  C07H21/04 ,  C12Q1/6837 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/553 ,  G01N2610/00

    摘要： An article suitable for use as a biosensor includes a species of a formula X--R--Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.

    摘要翻译： 适合用作生物传感器的制品包括作为自组装单层的一部分粘附到制品表面的式X-R-Ch的种类。 X是附着于表面的官能团，R是间隔基，Ch是螯合剂。 金属离子可以由螯合剂配位，并且靶向生物分子的聚氨基酸标记的生物结合配偶体与金属离子配位。 本发明的方法包括使制品与含有或怀疑含有靶生物分子的培养基接触并允许生物分子与结合配偶体生物结合。 该文章特别用作表面等离子体共振芯片。

    &ggr;, &dgr; T cell receptor and methods for detection
    10.
    发明授权
    &ggr;, &dgr; T cell receptor and methods for detection 失效
    γ，δT细胞受体和检测方法

    公开(公告)号：US06313263B1

    公开(公告)日：2001-11-06

    申请号：US08798574

    申请日：1997-02-10

    申请人： Michael B. Brenner ,  Jack L. Strominger ,  Johnathan Seidman ,  Stephen H. Ip ,  Michael S. Krangel

    发明人： Michael B. Brenner ,  Jack L. Strominger ,  Johnathan Seidman ,  Stephen H. Ip ,  Michael S. Krangel

    IPC分类号： A61K3800

    CPC分类号： C07K14/7051 ,  C07K16/2809 ,  C07K2317/34 ,  G01N33/56972 ,  Y10S530/868

    摘要： The present invention provides purified polypeptides which comprise at least a portion of a &dgr; T cell receptor polypeptide, a &ggr; T cell receptor polypeptide, a &ggr;, &dgr; T cell receptor complex or a &ggr;, &ggr; T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.

    摘要翻译： 本发明提供了包含至少一部分δT细胞受体多肽，γT细胞受体多肽，γ，δT细胞受体复合物或γ，γT细胞受体复合物的纯化多肽。 还提供能够与这些多肽形成复合物的物质。 此外，提供了检测在其内或其表面上具有本发明多肽的T细胞的方法。 此外，提供了用于诊断免疫系统异常的方法，其包括在受试者的样品中测量在其内或在其表面上具有本发明的多肽的T细胞的数量。