公开(公告)号：US20230280814A1

公开(公告)日：2023-09-07

申请号：US17683435

申请日：2022-03-01

申请人： Sameer Shekhar ,  Amit K. Jain ,  Chin Lee Kuan

发明人： Sameer Shekhar ,  Amit K. Jain ,  Chin Lee Kuan

IPC分类号： G06F1/3234 ,  G05F1/575 ,  H02M3/07

CPC分类号： G06F1/3234 ,  G05F1/575 ,  H02M3/07

摘要： An apparatus, system, and method for improved thermal design power (TDP) range are provided. A device includes a first voltage regulator configured to provide first voltage of a first voltage value, a second voltage regulator configured to provide a second voltage of a second, different voltage value, a first capacitor electrically coupled between a first output of the first voltage regulator and a ground, a second capacitor electrically coupled between a second output of the second voltage regulator and the ground, a first switch electrically coupled between the first output and the second output, a second switch situated in parallel with the first switch, the second switch electrically coupled between the first output and the second output, and a controller configured to provide control signals that control the first voltage regulator, the second voltage regulator, the first switch, and the second switch.

公开(公告)号：US08784879B2

公开(公告)日：2014-07-22

申请号：US12687586

申请日：2010-01-14

申请人： Parminder Singh ,  Eun Soo Lee ,  Amit K. Jain

发明人： Parminder Singh ,  Eun Soo Lee ,  Amit K. Jain

IPC分类号： A61K9/70 ,  A61F13/02 ,  A61K9/00 ,  A61K31/18 ,  A61K31/75 ,  C07C311/37

CPC分类号： A61K31/18 ,  A61K9/0014 ,  A61K9/70 ,  A61K9/7023 ,  A61K9/7053 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14

摘要： In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1-20 wt % of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.

摘要翻译： 在本发明的一个方面，提供了一种用于制备用于透皮给予坦索罗辛的贴剂的组合物。 组合物包含（a）至少约1重量％的坦索罗辛或其可药用的坦索罗辛盐，（b）至少约40重量％的聚异丁烯粘合剂或疏水性合成橡胶粘合剂，（c）约1-20重量％的非质子 其中坦索罗辛容易溶解的溶剂，（d）约1-20重量％的不饱和脂肪酸或α-羟基酸或不饱和脂肪酸或α-羟基酸或不饱和脂肪酸和α-羟基酸的混合物 ，（e）亲脂性渗透促进剂，和（f）基质改性剂。

公开(公告)号：US20090105260A1

公开(公告)日：2009-04-23

申请号：US11883606

申请日：2006-01-17

申请人： Samir Mitragotri ,  Pankaj Karande ,  Amit K. Jain

发明人： Samir Mitragotri ,  Pankaj Karande ,  Amit K. Jain

IPC分类号： A61K31/53 ,  C07D251/26 ,  C07C43/30 ,  C07D211/06 ,  A61K31/445 ,  A61K31/03 ,  G06F19/00 ,  G01N21/25 ,  A61K31/495 ,  A61K31/075 ,  C07D241/04 ,  C07C17/00

CPC分类号： A61B5/411 ,  A61B5/0075 ,  A61B5/445 ,  G01N21/35 ,  G16C20/30

摘要： An IR spectroscopic technique provides methods for measuring the irritation potential of a formulation and to assess the ability of molecules to enhance the permeability of substances into and through skin using samples comprising stratum corneum. Molecules are screened for their performance as chemical penetration enhancers using a unique in silico procedure that may be applied iteratively in an attempt to generate molecules showing successively higher performance. Both the irritation potential and the ability of the molecule to enhance penetration are considered in the in silico approach. The invention provides specific molecules that may be used in topical or transdermal formulations to improve the delivery of actives. The structures of compounds of the invention include: Formulas (I), (II), (III), (IV), (V), (IV) and analogs thereof.

摘要翻译： IR光谱技术提供了用于测量制剂的刺激电位的方法，并评估分子通过包含角质层的样品增强物质进入皮肤和通过皮肤的渗透性的能力。 使用独特的计算机程序筛选分子作为化学渗透增强剂的性能，其可以迭代地施用以试图产生显示连续更高性能的分子。 在计算机方法中考虑了刺激潜能和分子增强渗透能力。 本发明提供可用于局部或透皮制剂以改善活性物质递送的特定分子。 本发明化合物的结构包括：式（I），（II），（III），（IV），（V），（IV）及其类似物。

公开(公告)号：US20100291186A1

公开(公告)日：2010-11-18

申请号：US12687586

申请日：2010-01-14

申请人： Parminder Singh ,  Eun Soo Lee ,  Amit K. Jain

发明人： Parminder Singh ,  Eun Soo Lee ,  Amit K. Jain

IPC分类号： A61K9/70 ,  A61K31/18 ,  A61P13/08

CPC分类号： A61K31/18 ,  A61K9/0014 ,  A61K9/70 ,  A61K9/7023 ,  A61K9/7053 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14

摘要： In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1-20 wt % of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.

摘要翻译： 在本发明的一个方面，提供了一种用于制备用于透皮给予坦索罗辛的贴剂的组合物。 组合物包含（a）至少约1重量％的坦索罗辛或其可药用的坦索罗辛盐，（b）至少约40重量％的聚异丁烯粘合剂或疏水性合成橡胶粘合剂，（c）约1-20重量％的非质子 其中坦索罗辛容易溶解的溶剂，（d）约1-20重量％的不饱和脂肪酸或α-羟基酸或不饱和脂肪酸或α-羟基酸或不饱和脂肪酸和α-羟基酸的混合物 ，（e）亲脂性渗透促进剂，和（f）基质改性剂。