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    Imidazol-4-ylpiperidine derivatives, their preparation and their application in therapeutics
    1.
    发明授权
    Imidazol-4-ylpiperidine derivatives, their preparation and their application in therapeutics 失效
    咪唑-4-基哌啶衍生物，其制备及其在治疗中的应用

    公开(公告)号：US5589476A

    公开(公告)日：1996-12-31

    申请号：US317661

    申请日：1994-10-03

    申请人： Samir Jegham ,  G erard Defosse ,  Thomas A. Purcell ,  Luc Even

    发明人： Samir Jegham ,  G erard Defosse ,  Thomas A. Purcell ,  Luc Even

    IPC分类号： C07D401/14 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61P1/00 ,  C07D233/54 ,  C07D413/14 ,  C07D471/06 ,  C07D487/06 ,  C07D498/06 ,  C07D498/12 ,  A61K31/435 ,  C07D498/16

    CPC分类号： C07D471/06 ,  C07D487/06

    摘要： A compound of formula (I): ##STR1## in which R.sub.1 represents a hydrogen atom or a straight or branched (C.sub.1 -C.sub.4)alkyl group; andA represents a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group, a 4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-phenylmethyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 5-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 5,6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-2-yl group, a 6-oxo-5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group, or a 5-methyl-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2-yl group which may be unsubstituted or substituted in the 6-position by a phenylmethyl group;or an addition salt thereof with a pharmaceutically acceptable acid.

    摘要翻译： 式（I）的化合物：其中R 1表示氢原子或直链或支链（C 1 -C 4）烷基; A代表5,6-二氢-4H-咪唑并[4,5,1-ij]喹啉-2-基，4,5-二氢咪唑并[1,5,4-de] [1,4]苯并恶嗪 -2-基，4-甲基-4,5-二氢咪唑并[1,5,4-de] [1,4]苯并恶嗪-2-基，4-苯基-4,5-二氢咪唑并[ 5,4-de] [1,4]苯并恶嗪-2-基，4-苯基甲基-4,5-二氢咪唑并[1,5,4-de] [1,4]苯并恶嗪-2-基， 5-甲基-4,5-二氢咪唑并[1,5,4-de] [1,4]苯并恶嗪-2-基，5,6-二氢-4H-咪唑并[1,5,4-de]喹喔啉 -2-基，6-氧代-5,6-二氢-4H-咪唑并[4,5,1-ij]喹啉-2-基或5-甲基-4,5,6,7-四氢 - 四氢咪唑并[4,5,1-jk] [1,4]苯并二氮杂-2-基，其可以未取代或在6-位被苯甲基取代; 或其与药学上可接受的酸的加成盐。

    2-[4(3)-Amino-3(4)-hydroxyphenylimino]-imidazolines, useful in the treatment of gastric hypersecretion and hyperacidity
    2.
    发明授权
    2-[4(3)-Amino-3(4)-hydroxyphenylimino]-imidazolines, useful in the treatment of gastric hypersecretion and hyperacidity 失效
    2- [4（3） - 氨基-3（4） - 羟基苯基亚氨基]咪唑啉，可用于治疗胃分泌过多和过酸

    公开(公告)号：US4492709A

    公开(公告)日：1985-01-08

    申请号：US460993

    申请日：1983-01-25

    申请人： Thomas A. Purcell

    发明人： Thomas A. Purcell

    IPC分类号： A61K31/415 ,  A61P1/04 ,  A61P27/02 ,  A61P27/06 ,  C07D233/50 ,  C07D263/58 ,  C07D413/12 ,  C07D231/06

    CPC分类号： C07D263/58 ,  C07D233/50 ,  C07D413/12

    摘要： Imidazolidine derivatives of the formula: ##STR1## wherein R.sub.1 represents the hydroxy radical and R.sub.2 represents a grouping --NHSO.sub.2 CH.sub.3, --NHCOR' or --NHCONR'R", R' and R" independently of one another representing a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms, or alternatively R.sub.2 represents the hydroxy radical and R.sub.1 represents a grouping --NHSO.sub.2 CH.sub.3, --NHCOR' or ?NHCONR'R", R' and R" independently of one another representing a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms, and pharmacologically-acceptable acid addition salts thereof, are new therapeutically useful compounds. They are more particularly useful in the treatment of gastric hypersecretion or hyperacidity or glaucoma.

    摘要翻译： 其中R1表示羟基，R2表示-NHSO2CH3，-NHCOR'或-NHCONR'R“，R'和R”彼此独立地表示氢原子或式 具有1至4个碳原子的烷基，或者R2表示羟基，R1表示-NHSO2CH3，-NHCOR'或“NHCONR'R”，R'和R“彼此独立地表示氢原子 或具有1至4个碳原子的烷基及其药学上可接受的酸加成盐是新的治疗上有用的化合物。 它们在治疗胃分泌过多或胃酸过多或青光眼中更为特别有用。

    Antithrombotic method
    4.
    发明授权
    Antithrombotic method 失效
    抗血栓方法

    公开(公告)号：US4342759A

    公开(公告)日：1982-08-03

    申请号：US179460

    申请日：1980-08-19

    申请人： Thomas A. Purcell ,  Braham Shroot ,  Daniel Galtier

    发明人： Thomas A. Purcell ,  Braham Shroot ,  Daniel Galtier

    IPC分类号： A61K31/395 ,  C07D295/215 ,  A61K31/54 ,  A61K31/495

    CPC分类号： C07D295/215 ,  A61K31/395

    摘要： A method of treating a patient susceptible to thrombosis is provided which comprises treating the said patient with a compound of the formula ##STR1## wherein R' is H or CH.sub.3R is a ##STR2## radical in which Z is 0, S, SO, SO.sub.2 or NR.sub.1, R.sub.1 being H, C.sub.6 H.sub.5, CH.sub.3, CONR.sub.2 R.sub.3, COOR.sub.2, COR.sub.2 or SO.sub.2 R.sub.2, where R.sub.2 and R.sub.3 are, independently, H, C.sub.1-4 alkyl, C.sub.6 H.sub.5 or CF.sub.3.

    摘要翻译： 提供一种治疗易患血栓形成的患者的方法，其包括用下式化合物治疗所述患者：其中R'为H或CH 3 R为其中Z为0，S，SO， SO 2或NR 1，R 1是H，C 6 H 5，CH 3，CONR 2 R 3，COOR 2，COR 2或SO 2 R 2，其中R 2和R 3独立地是H，C 1-4烷基，C 6 H 5或CF 3。