公开(公告)号：US20160144028A1

公开(公告)日：2016-05-26

申请号：US14949303

申请日：2015-11-23

Applicant: Samsung Electronics Co., Ltd.

Inventor： Jimin Lee ,  Bo Gyou Kim ,  Seungja Oh ,  Kyung Ah Kim ,  Powei Lin ,  Saet Byoul Lee

IPC: A61K39/395 ,  G01N33/574 ,  A61K31/4985

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/4985 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  G01N33/57492 ,  G01N33/74 ,  G01N2333/65 ,  G01N2800/52

Abstract: A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met and EGFR (hereinafter, ‘c-Met/EGFR dual inhibitor’) and an IGF-1R inhibitor to a subject in need thereof and a use of IGF-1R as a marker for resistance to a c-Met/EGFR dual inhibitor

Abstract translation: 一种预防和/或治疗癌症的方法，所述方法包括将c-Met和EGFR双重抑制剂（以下称为“c-Met / EGFR双重抑制剂”）和IGF-1R抑制剂共同给予需要的受试者 并且使用IGF-1R作为对c-Met / EGFR双重抑制剂的抗性的标记物

公开(公告)号：US20160053025A1

公开(公告)日：2016-02-25

申请号：US14835376

申请日：2015-08-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seungja Oh ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Seung Hyun Lee ,  Ji Min Lee

IPC: C07K16/40 ,  A61K39/395 ,  A61K38/18 ,  C07K16/22

CPC classification number: A61K38/18 ,  A61K38/1891 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.

Abstract translation: 一种抗c-Met /抗Ang2双特异性抗体，包括（a）抗c-Met抗体或其抗原结合片段和（b）抗Ang2抗体或其抗原结合片段，药物组合物包括 抗c-Met /抗Ang2双特异性抗体，以及使用抗c-Met /抗Ang2双特异性抗体的方法。

公开(公告)号：US09943596B2

公开(公告)日：2018-04-17

申请号：US14949303

申请日：2015-11-23

Applicant: Samsung Electronics Co., Ltd.

Inventor： Jimin Lee ,  Bo Gyou Kim ,  Seungja Oh ,  Kyung Ah Kim ,  Powei Lin ,  Saet Byoul Lee

IPC: A61K39/395 ,  A61K31/4985 ,  G01N33/574 ,  A61K31/00 ,  C07K16/28 ,  G01N33/74 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/4985 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  G01N33/57492 ,  G01N33/74 ,  G01N2333/65 ,  G01N2800/52

Abstract: A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met and EGFR (hereinafter, ‘c-Met/EGFR dual inhibitor’) and an IGF-1R inhibitor to a subject in need thereof and a use of IGF-1R as a marker for resistance to a c-Met/EGFR dual inhibitor.

公开(公告)号：US09808507B2

公开(公告)日：2017-11-07

申请号：US14835376

申请日：2015-08-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seungja Oh ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Seung Hyun Lee ,  Ji Min Lee

IPC: C07K16/22 ,  A61K38/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K38/18 ,  A61K38/1891 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.