公开(公告)号：US20150140014A1

公开(公告)日：2015-05-21

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: C07K14/71 ,  A61K31/437 ,  A61K31/44 ,  A61K39/395 ,  A61K31/517

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.

Abstract translation: 一种预防或治疗癌症的方法，包括共同给予（a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种， （a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种提供给药物组合物 。

公开(公告)号：US10188647B2

公开(公告)日：2019-01-29

申请号：US14167711

申请日：2014-01-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Young Mi Oh ,  Kyung Ah Kim

IPC: A61K31/49 ,  A61K31/496 ,  C07K16/28 ,  A61K45/06 ,  A61K31/122 ,  A61K31/497 ,  A61K39/395

Abstract: A method of preventing and/or treating a cancer comprising co-administering a p53 activator and a c-Met inhibitor to a patient in need thereof.

公开(公告)号：US09213031B2

公开(公告)日：2015-12-15

申请号：US13949012

申请日：2013-07-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Ji Min Lee ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Young Mi Oh ,  Saet Byoul Lee ,  Yun Ju Jeong

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C07K16/30 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of identifying a cell sample or a subject suitable for treatment with an anti-c-Met antibody or antigen binding fragment thereof that specifically binds to an epitope within a SEMA domain of a c-Met protein by determining a Cbl concentration, a Cbl mutation, and/or a mutation of a site of c-Met for interaction with Cbl in a cell sample from a subject, as well as related compositions and methods.

Abstract translation: 一种鉴定细胞样本或适合于用抗c-Met抗体或其抗原结合片段治疗的受试者的方法，所述抗c-Met抗体或其抗原结合片段通过测定Cbl浓度特异性地结合c-Met蛋白质的SEMA结构域中的表位，Cbl 突变和/或与受试者的细胞样品中与Cbl相互作用的c-Met位点的突变，以及相关的组合物和方法。

公开(公告)号：US09717715B2

公开(公告)日：2017-08-01

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun Lee ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: A61K39/395 ,  A61K31/437 ,  A61K31/517 ,  A61K31/44 ,  C07K16/28 ,  C12N5/16

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.

公开(公告)号：US20140154251A1

公开(公告)日：2014-06-05

申请号：US14081917

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.

Abstract translation: 提供了抗c-Met抗体或抗体片段及包含其的药物组合物，以及通过向受试者施用抗体来预防和治疗癌症的方法。