公开(公告)号：US10792371B2

公开(公告)日：2020-10-06

申请号：US15884963

申请日：2018-01-31

Applicant: Samsung Electronics Co., Ltd.

Inventor： Su Young Chae ,  Sunghyun Kim ,  Eun Ko ,  Yun Ju Jeong ,  Jae Hyun Choi

IPC: C07K16/00 ,  A61K39/00 ,  A61K47/68

Abstract: Provided is a conjugate including a c-Met targeting compound and a bioactive material and methods of use of the conjugate.

公开(公告)号：US09572878B2

公开(公告)日：2017-02-21

申请号：US14227759

申请日：2014-03-27

Applicant: SAMSUNG ELECTRONICS CO., LTD. ,  SAMSUNG LIFE WELFARE FOUNDATION

Inventor： Saet Byoul Lee ,  Jae Hyun Choi ,  Kyung Ah Kim ,  Ji Min Lee ,  Yun Ju Jeong ,  Keunchil Park ,  Youngwook Kim ,  Yumi Lee

IPC: A61K39/395 ,  A61K31/517 ,  A61K31/5377

CPC classification number: A61K39/3955 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/00 ,  A61K2300/00

Abstract: A method of combination therapy for prevention and/or treatment of c-Met- and/or EGFR-induced diseases including co-administering a pharmaceutically effective amount of an EGFR antagonist and a pharmaceutically effective amount of an anti-c-Met antibody to a subject in need thereof is provided.

Abstract translation: 用于预防和/或治疗c-Met-和/或EGFR诱导的疾病的组合疗法的方法，包括将药学有效量的EGFR拮抗剂和药学上有效量的抗c-Met抗体共同施用于 提供了有需要的受试者。

公开(公告)号：US09889206B2

公开(公告)日：2018-02-13

申请号：US14485062

申请日：2014-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Su Young Chae ,  Sunghyun Kim ,  Eun Ko ,  Yun Ju Jeong ,  Jae Hyun Choi

IPC: A61K39/395 ,  A61K47/48

CPC classification number: A61K47/6859 ,  A61K47/6803 ,  A61K47/6851

Abstract: Disclosed is a conjugate in which a c-Met targeting compound and a bioactive material are chemically conjugated with each other, and methods of use thereof.

公开(公告)号：US09192666B2

公开(公告)日：2015-11-24

申请号：US14242684

申请日：2014-04-01

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo Gyou Kim ,  Ji Min Lee ,  Kyung Ah Kim ,  Yun Ju Jeong

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/28 ,  A61K31/506 ,  A61K31/519 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K31/506 ,  A61K31/519 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Provided is a method for prevention or treatment of a cancer, comprising co-administering (a) an FGFR inhibitor and (b) an anti-c-Met antibody or antigen-binding fragment thereof to a subject in need thereof, wherein the anti-c-Met antibody or the antigen-binding fragment thereof specifically binds to an epitope comprising 5 or more contiguous amino acids within the SEMA domain of c-Met protein.

Abstract translation: 本发明提供一种预防或治疗癌症的方法，其包括将（a）FGFR抑制剂和（b）抗c-Met抗体或其抗原结合片段共同给予有需要的受试者，其中， c-Met抗体或其抗原结合片段特异性结合到c-Met蛋白的SEMA结构域内包含5个或更多个连续氨基酸的表位。

公开(公告)号：US20150140014A1

公开(公告)日：2015-05-21

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: C07K14/71 ,  A61K31/437 ,  A61K31/44 ,  A61K39/395 ,  A61K31/517

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.

Abstract translation: 一种预防或治疗癌症的方法，包括共同给予（a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种， （a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种提供给药物组合物 。

公开(公告)号：US20140303357A1

公开(公告)日：2014-10-09

申请号：US14231580

申请日：2014-03-31

Applicant: Samsung Electronics Co., Ltd.

Inventor： In Hwan LIM ,  Dong Uk Kim ,  Geun Woong Kim ,  Hee Kyung Sung ,  Yun Ju Jeong

IPC: A61K39/395

CPC classification number: A61K39/39591 ,  A61K9/0019 ,  A61K9/08 ,  A61K47/183 ,  A61K47/26 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/92

Abstract: Disclosed is a method of preparing a stabilized liquid formulation of a protein drug, comprising admixing a protein drug with a composition for stabilization, wherein the composition for stabilization comprises a surfactant, a buffer, and a liquid medium, and has a pH from about 5 to about 8.

Abstract translation: 公开了一种制备蛋白质药物的稳定化液体制剂的方法，其包括将蛋白质药物与用于稳定化的组合物混合，其中用于稳定化的组合物包含表面活性剂，缓冲剂和液体培养基，并且具有约5 至约8。

公开(公告)号：US20180236097A1

公开(公告)日：2018-08-23

申请号：US15884963

申请日：2018-01-31

Applicant: Samsung Electronics Co., Ltd.

Inventor： Su Young Chae ,  Sunghyun Kim ,  Eun Ko ,  Yun Ju Jeong ,  Jae Hyun Choi

IPC: A61K47/68

Abstract: Provided is a conjugate including a c-Met targeting compound and a bioactive material and methods of use of the conjugate.

公开(公告)号：US09931400B2

公开(公告)日：2018-04-03

申请号：US14025403

申请日：2013-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju Jeong ,  Kyung Ah Kim ,  Yun Jeong Song ,  Ji Min Lee ,  Hyo Seon Lee ,  Jae Hyun Choi ,  Saet Byoul Lee

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K45/06 ,  C07K16/2863 ,  C07K2317/24

Abstract: Provided is a method of combination therapy for prevention or treatment of c-Met-induced or angiogenesis factor-induced diseases including co-administering an angiogenesis inhibitor and an anti-c-Met antibody or an antigen-binding fragment thereof to a patient.

公开(公告)号：US09717715B2

公开(公告)日：2017-08-01

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun Lee ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: A61K39/395 ,  A61K31/437 ,  A61K31/517 ,  A61K31/44 ,  C07K16/28 ,  C12N5/16

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.

公开(公告)号：US09650443B2

公开(公告)日：2017-05-16

申请号：US14228521

申请日：2014-03-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Jeong Song ,  Ho Yeong Song ,  Seung Hyun Lee ,  Kyung Ah Kim ,  Yun Ju Jeong

IPC: C07K16/46 ,  A61K39/00 ,  C07K16/28 ,  C07K14/71

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K14/71 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.