公开(公告)号：US20220339258A1

公开(公告)日：2022-10-27

申请号：US17295385

申请日：2021-02-09

申请人： Samsung Life Public Welfare Foundation

发明人： Jong Wook Chang ,  Hyeong Seop Kim

IPC分类号： A61K38/22 ,  C12N5/0775 ,  A61P25/28 ,  A61K35/28

摘要： Disclosed is a producing method of a mesenchymal stem cell for brain neuronal disease prevention or treatment including ghrelin treatment, a composition for producing a mesenchymal stem cell for brain neuronal disease prevention or treatment, a mesenchymal stem cell produced by the producing method, and a pharmaceutical composition for prevention or treatment of brain neuronal disease containing the same. When using the producing method of the mesenchymal stem cells with the increased AgRP (Agouti related peptide) expression level according to the present disclosure, the mesenchymal stem cells produced by the method, or ghrelin, various brain neuronal diseases such as Alzheimer's disease may be effectively prevented or treated. When the composition for producing the mesenchymal stem cells with the increased AgRP expression level containing ghrelin according to the present disclosure is used, the mesenchymal stem cells with the increased AgRP expression level may be effectively produced.

公开(公告)号：US11946070B2

公开(公告)日：2024-04-02

申请号：US17054939

申请日：2020-07-15

申请人： SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

发明人： Duk Lyul Na ,  Jong Wook Chang ,  Hyo Jin Son

IPC分类号： C12N5/0735 ,  A61K35/51 ,  A61K35/545 ,  A61P25/28 ,  A61P29/00 ,  C12N5/0775

CPC分类号： C12N5/0606 ,  A61K35/51 ,  A61K35/545 ,  A61P25/28 ,  A61P29/00 ,  C12N5/0665 ,  C12N2501/999

摘要： The present invention relates to a medium composition for reinforcing the efficacy of stem cells, including ethionamide, a method of reinforcing the efficacy of stem cells, including culturing stem cells in the medium composition, a method of preparing stem cells with reinforced efficacy, stem cells prepared by the above-mentioned method, and a use thereof. According to the present invention, the anti-inflammatory effect of mesenchymal stem cells and expression levels of paracrine factors may be effectively improved by a simple method of treating mesenchymal stem cells with ethionamide, and the stem cells obtained by the above method may be effectively used for preventing or treating an inflammatory disease or a degenerative brain disease.

公开(公告)号：US11913020B2

公开(公告)日：2024-02-27

申请号：US16760004

申请日：2018-10-08

申请人： Samsung Life Public Welfare Foundation

发明人： Duk Lyul Na ,  Jong Wook Chang ,  Hyo Jin Son

IPC分类号： C12N5/0735 ,  A61K35/51 ,  C12N5/0775

CPC分类号： C12N5/0606 ,  A61K35/51 ,  C12N5/0663 ,  C12N5/0665 ,  C12N5/0668 ,  C12N2501/999

摘要： The present invention relates to a medium composition for improving stem cell migration, which includes ethionamide, and a use thereof. According to the present invention, the migration of stem cells may be effectively improved by the adjustment of a culture environment, which is a simple and safe method, without using gene manipulation or a viral vector, and the stem cells improved in migration by the method may be effectively used as a stem cell therapeutic agent that is able to function by rapidly migrating to the damaged region after transplantation.

公开(公告)号：US20230146610A1

公开(公告)日：2023-05-11

申请号：US18152464

申请日：2023-01-10

申请人： SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

发明人： Duk Lyul NA ,  Jong Wook Chang ,  Hyo Jin Son ,  Su Hyeon Myeong

IPC分类号： C12N5/0775

CPC分类号： C12N5/0665 ,  C12N2501/999

摘要： The present disclosure relates to a medium composition for enhancing proliferation of stem cells, comprising ethionamide, and a use thereof. It is possible, according to the present disclosure, to mass-produce highly-efficient next-generation stem cells through a simple and safe method of controlling a culturing environment, without using genetic modification or viral vectors, etc.