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公开(公告)号：US20090263327A1
公开(公告)日：2009-10-22
申请号：US12476169
申请日：2009-06-01
申请人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
IPC分类号： A61K49/04 , A61K9/127 , A61K9/50 , A61K31/40 , C07D209/56
CPC分类号： A61K31/405 , C07D209/08 , C07D209/18 , C07D209/24 , C07D209/60 , C09B23/0025 , C09B23/0066 , C09B23/0075 , C09B23/08
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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2.发明授权公开(公告)号：US07128896B2
公开(公告)日：2006-10-31
申请号：US10847121
申请日：2004-05-17
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
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公开(公告)号：US06264919B1
公开(公告)日：2001-07-24
申请号：US09636170
申请日：2000-08-10
IPC分类号： A61B1000
CPC分类号： A61K49/0056 , A61K41/0033 , A61K41/0057 , A61K49/0032
摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
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4.发明授权公开(公告)号：US07201892B2
公开(公告)日：2007-04-10
申请号：US10847257
申请日：2004-05-17
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
摘要翻译： 公开了新型肿瘤特异性光疗法和光诊断剂。 该化合物包括用于可视化的碳菁染料，用于光动力学治疗的光敏剂和用于将位点特异性递送探针和光毒性剂到患病组织的肿瘤受体 - 鸟苷肽。 这些元素的组合充分利用了每个组件的独特而有效的特性来进行有效的患者护理管理。
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5.发明授权Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients 失效亲水性光吸收吲哚化合物，用于确定重症患者的生理功能公开(公告)号：US06669926B1
公开(公告)日：2003-12-30
申请号：US09688943
申请日：2000-10-16
IPC分类号： A61B1000
CPC分类号： C07D209/58 , A61K31/403 , A61K49/0021 , A61K49/0032 , C07D209/08 , C07D209/12 , C07D209/60
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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公开(公告)号：US06264920B1
公开(公告)日：2001-07-24
申请号：US09637518
申请日：2000-08-10
IPC分类号： A61B1000
CPC分类号： A61K41/0033
摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
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公开(公告)号：US06190641B1
公开(公告)日：2001-02-20
申请号：US09484323
申请日：2000-01-18
IPC分类号： A61B1000
CPC分类号： A61K49/0056 , A61K41/0033 , A61K41/0057 , A61K49/0032
摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发射光的新型吲哚菁染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。
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公开(公告)号：US07438894B2
公开(公告)日：2008-10-21
申请号：US10680338
申请日：2003-10-07
申请人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
CPC分类号： C07D209/56 , A61K49/0021 , A61K49/0032 , C07D209/08 , C07D209/62 , C09B23/0066 , C09B23/0075 , C09B23/02
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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9.发明授权Hydrophilic light absorbing compositions for determination of physiological function 失效用于测定生理功能的亲水性光吸收组合物公开(公告)号：US07297325B2
公开(公告)日：2007-11-20
申请号：US10744334
申请日：2003-12-23
申请人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
CPC分类号： C07D209/58 , A61K31/403 , A61K49/0021 , A61K49/0032 , C07D209/08 , C07D209/12 , C07D209/60
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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公开(公告)号：US06656451B1
公开(公告)日：2003-12-02
申请号：US09688947
申请日：2000-10-16
IPC分类号： A61B1000
CPC分类号： C07D209/56 , A61K49/0021 , A61K49/0032 , C07D209/08 , C07D209/62 , C09B23/0066 , C09B23/0075 , C09B23/02
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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