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公开(公告)号：US06358972B1
公开(公告)日：2002-03-19
申请号：US09701934
申请日：2000-12-05
IPC分类号： A61K31435
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to a compound of formula (I): or a pharmaceutical acid addition salt thereof; which is useful for activating 5-HT1f receptors and inhibiting protein extravasation in a mammal.
摘要翻译： 本发明涉及式（I）化合物或其药用酸加成盐： 其可用于激活哺乳动物中的5-HT1f受体并抑制蛋白质外渗。
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公开(公告)号：US07144898B2
公开(公告)日：2006-12-05
申请号：US10149476
申请日：2000-12-06
申请人： Marvin Martin Hansen , John Xiaoqiang He , Nicholas Allan Honigschmidt , Daniel James Koch , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
发明人： Marvin Martin Hansen , John Xiaoqiang He , Nicholas Allan Honigschmidt , Daniel James Koch , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
IPC分类号： A11K31/445
CPC分类号： C07D401/12 , C07D409/14 , C07D417/14
摘要： The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
摘要翻译： 本发明提供了式（I）化合物：其可用于治疗抑郁，焦虑和减轻由于使用烟草或尼古丁引起的部分戒断引起的症状。
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3.发明授权5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1h-indoles: 5-HT.sub.1F agonists 失效5-取代-3-（1,2,3,6-四氢吡啶-4-基） - 和3-（哌啶-4-基）-1H-吲哚：5-HT1F激动剂
公开(公告)号：US5962474A
公开(公告)日：1999-10-05
申请号：US977526
申请日：1997-11-24
申请人： James Edmund Audia , Bruce Anthony Dressman , James Joseph Droste , James Erwin Fritz , Stephen Warren Kaldor , Daniel James Koch , Joseph Herman Krushinski, Jr. , Jeffrey Scott Nissen , Vincent Patrick Rocco , John Mehnert Schaus , Dennis Charles Thompson
发明人： James Edmund Audia , Bruce Anthony Dressman , James Joseph Droste , James Erwin Fritz , Stephen Warren Kaldor , Daniel James Koch , Joseph Herman Krushinski, Jr. , Jeffrey Scott Nissen , Vincent Patrick Rocco , John Mehnert Schaus , Dennis Charles Thompson
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P25/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , A61K31/40
CPC分类号： C07D401/04 , C07D401/14 , C07D407/14 , C07D409/14 , Y02P20/582
摘要： This invention provides novel 5-HT.sub.1F agonists of Formula I ##STR1## where A--B, R,R.sup.1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
摘要翻译： 本发明提供式I的新型5-HT1F激动剂，其中A-B，R，R 1和X如说明书中所定义，其可用于治疗偏头痛及相关疾病。
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公开(公告)号：US5912256A
公开(公告)日：1999-06-15
申请号：US861445
申请日：1997-05-22
IPC分类号： A61K31/454 , C07D401/12 , A61K31/445 , A61K31/495 , C07D401/14
CPC分类号： C07D401/12 , A61K31/454
摘要： A series of 1-(4-indolyloxy)-3-(4-hydroxy-4-naphthylpiperidin-1-yl)propanes are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor, yet lack mutagenic potential as measured by assays of chromosomal aberration. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列1-（4-吲哚氧基）-3-（4-羟基-4-萘基哌啶-1-基）丙烷是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物 ，但通过染色体畸变的测定测量，缺乏诱变潜力。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US06303627B1
公开(公告)日：2001-10-16
申请号：US09325302
申请日：1999-06-03
IPC分类号： A61K3144
CPC分类号： C07D417/04 , C07D211/12 , C07D211/16 , C07D211/20 , C07D211/70 , C07D211/74
摘要： This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
摘要翻译： 本发明提供化合物和抑制哺乳动物中5-羟色胺再摄取的方法
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公开(公告)号：US06242450B1
公开(公告)日：2001-06-05
申请号：US09335083
申请日：1999-06-17
IPC分类号： A61K31495
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
摘要： This invention provides 5-HT1f antagonists of Formula I: where AR1, AR2, R, and R′ are as defined in the specification.
摘要翻译： 本发明提供式I的5-HT1f拮抗剂：其中AR1，AR2，R和R'如说明书中所定义。
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7.发明授权5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1H-indoles: new 5-HT.sub.1F agonists 失效5-取代的3-（1,2,3,6-四氢吡啶-4-基） - 和3-（哌啶-4-基）-1H-吲哚：新的5-HT1F激动剂
公开(公告)号：US5708008A
公开(公告)日：1998-01-13
申请号：US619783
申请日：1996-03-20
申请人： James Edmund Audia , Bruce Anthony Dressman , James Joseph Droste , James Erwin Fritz , Stephen Warren Kaldor , Daniel James Koch , Joseph Herman Krushinski, Jr. , Jeffrey Scott Nissen , Vincent Patrick Rocco , John Mehnert Schaus , Dennis Charles Thompson
发明人： James Edmund Audia , Bruce Anthony Dressman , James Joseph Droste , James Erwin Fritz , Stephen Warren Kaldor , Daniel James Koch , Joseph Herman Krushinski, Jr. , Jeffrey Scott Nissen , Vincent Patrick Rocco , John Mehnert Schaus , Dennis Charles Thompson
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P25/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D407/14 , C07D409/14 , Y02P20/582
摘要： This invention provides novel 5-HT.sub.1F agonists of Formula I ##STR1## where A--B, R, R.sup.1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
摘要翻译： 本发明提供式I的新型5-HT1F激动剂，其中A-B，R，R 1和X如说明书中所定义，其可用于治疗偏头痛及相关疾病。
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