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    PHARMACEUTICAL COMPOSITIONS FOR RELEASE CONTROL OF METHYLPHENIDATE
    1.
    发明申请
    PHARMACEUTICAL COMPOSITIONS FOR RELEASE CONTROL OF METHYLPHENIDATE 有权
    药物组合物用于释放甲基苯甲酸酯的控制

    公开(公告)号：US20110223247A1

    公开(公告)日：2011-09-15

    申请号：US13126855

    申请日：2009-11-06

    申请人： Sang Yeob Park ,  Hojin Chung ,  Chaul Min Pai

    发明人： Sang Yeob Park ,  Hojin Chung ,  Chaul Min Pai

    IPC分类号： A61K9/58 ,  A61K9/00 ,  A61K9/22 ,  A61K9/54 ,  A61K31/445 ,  A61P25/00 ,  A61K9/56

    CPC分类号： A61K9/0095 ,  A61K9/0056 ,  A61K9/5073 ,  A61K31/445

    摘要： Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.

    摘要翻译： 公开了一种用于释放控制的药物组合物，其包含多个用于释放控制的颗粒。 用于释放控制的多个颗粒包括含有哌甲酯的核心材料和用于在芯材上形成的用于释放控制的聚合物涂层。 用于释放控制的多个颗粒基于用于释放控制的聚合物涂层的平均厚度被分成两组或更多组。 在聚合物涂层中聚合物的组成方面，颗粒组是相同的，但是在涂层的平均厚度方面是不同的。 根据本发明的用于释放控制的药物组合物可以根据需要控制核心材料中所含的哌甲酯的释放模式，并且可以以各种形式如口腔崩解片等的口服制剂使用。

    Pharmaceutical compositions for release control of methylphenidate
    2.
    发明授权
    Pharmaceutical compositions for release control of methylphenidate 有权
    哌甲酯释放控制药物组合物

    公开(公告)号：US08465768B2

    公开(公告)日：2013-06-18

    申请号：US13126855

    申请日：2009-11-06

    申请人： Sang Yeob Park ,  Hojin Chung ,  Chaul Min Pai

    发明人： Sang Yeob Park ,  Hojin Chung ,  Chaul Min Pai

    IPC分类号： A61K9/58

    CPC分类号： A61K9/0095 ,  A61K9/0056 ,  A61K9/5073 ,  A61K31/445

    摘要： Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.

    摘要翻译： 公开了一种用于释放控制的药物组合物，其包含多个用于释放控制的颗粒。 用于释放控制的多个颗粒包括含有哌甲酯的核心材料和用于在芯材上形成的用于释放控制的聚合物涂层。 用于释放控制的多个颗粒基于用于释放控制的聚合物涂层的平均厚度被分成两组或更多组。 在聚合物涂层中聚合物的组成方面，颗粒组是相同的，但是在涂层的平均厚度方面是不同的。 根据本发明的用于释放控制的药物组合物可以根据需要控制核心材料中所含的哌甲酯的释放模式，并且可以以各种形式如口腔崩解片等的口服制剂使用。

    Highly plastic granules for making fast melting tablets
    3.
    发明授权
    Highly plastic granules for making fast melting tablets 失效
    用于制作快速熔融片的高度塑料颗粒

    公开(公告)号：US07749533B2

    公开(公告)日：2010-07-06

    申请号：US10841979

    申请日：2004-05-07

    申请人： Yourong Fu ,  Chaul Min Pai ,  Sang Yeob Park ,  Gun Seomoon ,  Kinam Park

    发明人： Yourong Fu ,  Chaul Min Pai ,  Sang Yeob Park ,  Gun Seomoon ,  Kinam Park

    IPC分类号： A61K9/20 ,  A61K9/16

    CPC分类号： A61K9/0056

    摘要： A fast-melting pharmaceutical tablet comprises a porous, plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the porous, plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.

    摘要翻译： 快速熔化的药物片剂包括多孔塑料物质，水渗透增强剂和粘合剂。 可以在该方法的不同阶段将一种或多种药物并入制剂中，从而得到药用活性片剂。 制备药片的方法需要结合多孔，塑料，水渗透增强剂和粘合剂，以形成高度塑性的颗粒，将其压制成片剂。 所得片剂迅速溶于口中，硬度好，脆性低。 这些片剂对吞咽常规药丸有困难的人特别有价值。

    Transdermal composition of an antivomiting agent
    4.
    发明授权
    Transdermal composition of an antivomiting agent 有权
    抗病毒剂的透皮组合物

    公开(公告)号：US07273619B2

    公开(公告)日：2007-09-25

    申请号：US10414827

    申请日：2003-04-15

    申请人： Chaul Min Pai ,  Jin Deog Song ,  Joong Woong Cho

    发明人： Chaul Min Pai ,  Jin Deog Song ,  Joong Woong Cho

    IPC分类号： A61F13/00 ,  A61F15/16

    CPC分类号： A61K9/0014 ,  A61K9/7023 ,  A61K31/00 ,  A61K31/46 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/38

    摘要： The present invention relates to a transdermal composition of an antivomiting agent, and more particularly to a transdermal composition of an antivomiting agent which can minimize skin irritation by employing tropisetron as the antivomiting agent as well as by adjusting its pH to be in the range of 8 to 9 thus enhancing its rate of skin penetration thereby reducing the amount of a skin penetration enhancer used.

    摘要翻译： 本发明涉及抗病毒剂的透皮组合物，更具体地说，涉及一种抗病毒剂的透皮组合物，其可以通过使用托烷司琼作为抗病毒剂，并通过将其pH调节至8范围内来最小化皮肤刺激 从而提高其皮肤渗透速率，从而减少使用的皮肤渗透增强剂的量。

    Preparation of peptide containing biodegradable microspheres by melt process
    8.
    发明授权
    Preparation of peptide containing biodegradable microspheres by melt process 失效
    通过熔融法制备含可生物降解微球的肽

    公开(公告)号：US5665428A

    公开(公告)日：1997-09-09

    申请号：US547962

    申请日：1995-10-25

    申请人： Younsik Cha ,  Young Kweon Choi ,  Chaul Min Pai

    发明人： Younsik Cha ,  Young Kweon Choi ,  Chaul Min Pai

    IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K38/00 ,  A61K38/23 ,  A61K38/28 ,  A61K38/38 ,  A61K47/48 ,  B01J13/02 ,  B05D7/00

    CPC分类号： A61K38/23 ,  A61K38/28 ,  A61K38/38 ,  A61K9/1647 ,  B01J13/02

    摘要： Peptide/protein biodegradable drug delivery devices are prepared as microspheres without the use of solvents by a polymer melt process. A melt of thermostable polypeptides and an appropriate low melting block copolymer mixture is prepared and dispersed in an appropriate fluid medium such as air, water or an immiscible organic fluid without using any organic solvent to form microdroplets. The fluid medium is cooled to solidify the microdroplets into microspheres and then collected and purified or further processed as drug delivery devices. These biodegradable microspheres are suitable as implantable or injectable pharmaceutical formulations. Following administration as solid microspheres into the body of a warm blooded animal, the formulations absorb water from the body to form a hydrogel from which the polypeptide is released continuously over an extended period of time.

    摘要翻译： 肽/蛋白质可生物降解的药物递送装置通过聚合物熔融方法制备为不使用溶剂的微球。 制备热稳定多肽和合适的低熔点嵌段共聚物混合物的熔体并将其分散在合适的流体介质如空气，水或不混溶的有机流体中，而不使用任何有机溶剂形成微滴。 将流体培养基冷却以将微滴固化成微球，然后收集并纯化或进一步加工为药物递送装置。 这些可生物降解的微球体适合作为可植入或可注射的药物制剂。 在作为固体微球体施用于温血动物的体内后，制剂吸收来自身体的水以形成水凝胶，多肽在延长的时间段内连续释放。