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    MRI CONTRAST AGENT HAVING GADOLINIUM COMPLEX
    6.
    发明申请
    MRI CONTRAST AGENT HAVING GADOLINIUM COMPLEX 有权
    具有金属复合物的MRI对比剂

    公开(公告)号：US20130231475A1

    公开(公告)日：2013-09-05

    申请号：US13876904

    申请日：2010-12-21

    申请人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    发明人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    IPC分类号： C07F5/00 ,  C07D257/02

    CPC分类号： C07F5/00 ,  A61K49/106 ,  C07D257/02

    摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1. A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.

    摘要翻译： 本发明涉及包含钆络合物的磁共振成像（MRI）造影剂，更具体地说，涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物 可以根据本发明制备，并且可以使用该化合物制备钆络合物。 包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。 此外，根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。 因此，由于包含本发明的钆配合物的MRI造影剂满足MRI造影剂所需的关键性质，因此可以广泛用作MRI造影剂，与现有的对比度相比可以提供增强的对比效果 代理商

    MRI contrast agent having gadolinium complex
    7.
    发明授权
    MRI contrast agent having gadolinium complex 有权
    具有钆络合物的MRI造影剂

    公开(公告)号：US08901294B2

    公开(公告)日：2014-12-02

    申请号：US13876904

    申请日：2010-12-21

    申请人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    发明人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    IPC分类号： C07D257/02 ,  C07F5/00 ,  A61K49/10

    CPC分类号： C07F5/00 ,  A61K49/106 ,  C07D257/02

    摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1. A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.

    摘要翻译： 本发明涉及包含钆络合物的磁共振成像（MRI）造影剂，更具体地涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物 可以根据本发明制备，并且可以使用该化合物制备钆络合物。 包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。 此外，根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。 因此，由于包含本发明的钆配合物的MRI造影剂满足MRI造影剂所需的关键性质，因此可以广泛用作MRI造影剂，与现有的对比度相比可以提供增强的对比效果 代理商