利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.015 秒)

    MRI CONTRAST AGENT HAVING GADOLINIUM COMPLEX
    1.
    发明申请
    MRI CONTRAST AGENT HAVING GADOLINIUM COMPLEX 有权
    具有金属复合物的MRI对比剂

    公开(公告)号：US20130231475A1

    公开(公告)日：2013-09-05

    申请号：US13876904

    申请日：2010-12-21

    申请人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    发明人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    IPC分类号： C07F5/00 ,  C07D257/02

    CPC分类号： C07F5/00 ,  A61K49/106 ,  C07D257/02

    摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1. A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.

    摘要翻译： 本发明涉及包含钆络合物的磁共振成像（MRI）造影剂，更具体地说，涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物 可以根据本发明制备，并且可以使用该化合物制备钆络合物。 包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。 此外，根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。 因此，由于包含本发明的钆配合物的MRI造影剂满足MRI造影剂所需的关键性质，因此可以广泛用作MRI造影剂，与现有的对比度相比可以提供增强的对比效果 代理商

    Hollow Fiber Membrane and Preparing Method Thereof
    2.
    发明申请
    Hollow Fiber Membrane and Preparing Method Thereof 审中-公开
    中空纤维膜及其制备方法

    公开(公告)号：US20080261017A1

    公开(公告)日：2008-10-23

    申请号：US12089135

    申请日：2006-10-09

    申请人： Sung Su Bae ,  Tae Jeong Kim ,  Sang Hoon Kim ,  Soon Hyuk Im ,  Hang Duk Rho

    发明人： Sung Su Bae ,  Tae Jeong Kim ,  Sang Hoon Kim ,  Soon Hyuk Im ,  Hang Duk Rho

    IPC分类号： C08K5/06

    CPC分类号： B01D69/141 ,  B01D69/081 ,  B01D71/34 ,  B01D2323/18 ,  B01D2325/022 ,  C08K5/053 ,  D01D5/24 ,  D01F6/12 ,  Y10T428/249978 ,  C08L27/16

    摘要： The present invention relates to a polyvinylidene difluoride hollow fiber membrane and a method of preparing the same, and more particularly, to an improved polyvinylidene difluoride hollow fiber membrane and a preparation method thereof, in which a spinning solution consisting of polyvinylidene fluoride, alcohol dendrimer and organic solvent is prepared, and then is subjected to solidification by a wet-phase transition process, cleaning and drying, in which alcohol dendrimer that is an organic material as a pore former is introduced, allowing uniform disperse of alcohol dendrimer in polyvinylidene difluoride to form pores, with each having a high dispersion ability and a uniform size, and in which an excellent adhesion durability is imparted, owing to the use of a single material of polyvinylidene difluoride, unlike the conventional hollow fiber membrane preparation method in which pores are formed using existing inorganic particles.

    摘要翻译： 本发明涉及一种聚偏二氟乙烯中空纤维膜及其制备方法，更具体地说，涉及一种改进的聚偏二氟乙烯中空纤维膜及其制备方法，其中将由聚偏二氟乙烯，醇树枝状聚合物和 制备有机溶剂，然后通过湿相变过程，清洗和干燥进行固化，其中引入作为成孔剂的有机材料的醇树枝状聚合物，使得醇枝状聚合物均匀分散在聚偏二氟乙烯中以形成 由于使用聚偏二氟乙烯的单一材料，由于使用了单一的聚偏二氟乙烯材料，所以具有高的分散能力和均匀的尺寸，并且赋予了优异的粘合耐久性的孔，这不同于传统的中空纤维膜制备方法，其中使用 现有无机颗粒。

    MRI contrast agent having gadolinium complex
    3.
    发明授权
    MRI contrast agent having gadolinium complex 有权
    具有钆络合物的MRI造影剂

    公开(公告)号：US08901294B2

    公开(公告)日：2014-12-02

    申请号：US13876904

    申请日：2010-12-21

    申请人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    发明人： Tae-Jeong Kim ,  Yong Min Chang ,  Hee-Kyung Kim ,  Sung-Wook Gu

    IPC分类号： C07D257/02 ,  C07F5/00 ,  A61K49/10

    CPC分类号： C07F5/00 ,  A61K49/106 ,  C07D257/02

    摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1. A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.

    摘要翻译： 本发明涉及包含钆络合物的磁共振成像（MRI）造影剂，更具体地涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物 可以根据本发明制备，并且可以使用该化合物制备钆络合物。 包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。 此外，根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。 因此，由于包含本发明的钆配合物的MRI造影剂满足MRI造影剂所需的关键性质，因此可以广泛用作MRI造影剂，与现有的对比度相比可以提供增强的对比效果 代理商

    Production method of titanium dioxide (TiO2) photocatalyst and TiO2 photocatalyst produced by the same
    4.
    发明授权
    Production method of titanium dioxide (TiO2) photocatalyst and TiO2 photocatalyst produced by the same 有权
    二氧化钛（TiO2）光催化剂和TiO2光催化剂的制备方法

    公开(公告)号：US07851407B2

    公开(公告)日：2010-12-14

    申请号：US12122956

    申请日：2008-05-19

    申请人： Tae Jeong Kim ,  Wha Jung Kim ,  Sun Woo Kim

    发明人： Tae Jeong Kim ,  Wha Jung Kim ,  Sun Woo Kim

    IPC分类号： B01J23/00 ,  C01G25/02 ,  C01G27/02 ,  C01G23/047 ,  C09K3/00

    CPC分类号： B01J37/033 ,  B01J21/063 ,  B01J21/066 ,  B01J35/004 ,  B82Y30/00 ,  C01G23/053 ,  C01P2002/72 ,  C01P2002/77 ,  C01P2002/82 ,  C01P2002/85 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  C01P2006/17

    摘要： A method for producing a titanium dioxide photocatalyst is provided. The method uses a sol-gel process wherein acid and base catalysts are added in two separate steps. According to the method, a titanium dioxide photocatalyst with increased mesoporosity can be produced without the use of any particular additive. Further, an anatase structure is formed upon drying and is maintained even after high-temperature calcination. Further provided is a titanium dioxide photocatalyst produced by the method. Further provided is a titanium dioxide photocatalyst doped with sulfur and zirconium, which is produced by using the method. The doped titanium dioxide photocatalyst exhibits catalytic activity even under visible light and excellent surface characteristics to achieve improved photocatalytic activity.

    摘要翻译： 提供了制备二氧化钛光催化剂的方法。 该方法使用溶胶 - 凝胶法，其中酸和碱催化剂分两步加入。 根据该方法，可以在不使用任何特定添加剂的情况下制造具有增加的介孔性的二氧化钛光催化剂。 此外，在干燥后形成锐钛矿结构，即使在高温煅烧后也保持锐钛矿结构。 还提供了通过该方法制备的二氧化钛光催化剂。 还提供了使用该方法制备的掺杂有硫和锆的二氧化钛光催化剂。 掺杂的二氧化钛光催化剂即使在可见光下也表现出催化活性，并且具有优异的表面特性以获得改善的光催化活性。

    Paramagnetic polynuclear metal complex having high self-relaxation rate, preparation method thereof, and contrast medium containing same
    6.
    发明授权
    Paramagnetic polynuclear metal complex having high self-relaxation rate, preparation method thereof, and contrast medium containing same 有权
    具有高自松弛率的顺磁性多核金属络合物，其制备方法和含有它的造影剂

    公开(公告)号：US08822697B2

    公开(公告)日：2014-09-02

    申请号：US13393898

    申请日：2009-11-11

    申请人： Tae Jeong Kim ,  Yong Min Chang ,  Hee Kyung Kim

    发明人： Tae Jeong Kim ,  Yong Min Chang ,  Hee Kyung Kim

    IPC分类号： C07F5/00 ,  C07D233/64 ,  C07C229/28 ,  C07C229/24 ,  C07C229/26 ,  A61K49/10

    CPC分类号： C07D233/64 ,  A61K49/103 ,  C07C229/24 ,  C07C229/26 ,  C07C229/28 ,  C07F5/003

    摘要： The present invention relates to a paramagnetic polynuclear metal complex having enhanced self-relaxation rate and thermodynamic stability, and more particularly, to a synthetic method of a novel DTPA-bis-amide-histidine ligand and DTPA-bis-amide-aspartic acid ligand, a novel gadolinium complex ([Gd(L)H2O]) using the ligand, and a paramagnetic polynuclear metal complex using the gadolinium complex. The paramagnetic polynuclear metal complex is able to fix three or more metals (one gadolinium and two metal ions), thereby providing more excellent self-relaxation rate than the commercially available contrast agents. Thus, it can be widely applied to an MRI contrast agent because of meeting the high self-relaxation rate required as a contrast agent of magnetic resonance imaging (MRI).

    摘要翻译： 本发明涉及具有增强的自松弛率和热力学稳定性的顺磁性多核金属络合物，更具体地说，涉及新的DTPA-双 - 酰胺 - 组氨酸配体和DTPA-双 - 酰胺 - 天冬氨酸配体的合成方法， 使用配体的新型钆络合物（[Gd（L）H 2 O]）和使用钆络合物的顺磁性多核金属络合物。 顺磁性多核金属络合物能够固定三种或更多种金属（一种钆和两种金属离子），从而提供比市售造影剂更优异的自松弛率。 因此，由于满足作为磁共振成像（MRI）的造影剂所需的高自放松率，可以广泛地应用于MRI造影剂。

    Paramagnetic Polynuclear Metal Complex Having High Self-Relaxation Rate, Preparation Method Thereof, and Contrast Medium Containing Same
    7.
    发明申请
    Paramagnetic Polynuclear Metal Complex Having High Self-Relaxation Rate, Preparation Method Thereof, and Contrast Medium Containing Same 有权
    具有高自松弛速率的顺磁性多核金属络合物，其制备方法和含有其的对比介质

    公开(公告)号：US20120226048A1

    公开(公告)日：2012-09-06

    申请号：US13393898

    申请日：2009-11-11

    申请人： Tae Jeong Kim ,  Yong Min Chang ,  Hee Kyung Kim

    发明人： Tae Jeong Kim ,  Yong Min Chang ,  Hee Kyung Kim

    IPC分类号： C07F3/00 ,  C07F3/06 ,  C07D403/12 ,  C07C237/12 ,  C07D233/64

    CPC分类号： C07D233/64 ,  A61K49/103 ,  C07C229/24 ,  C07C229/26 ,  C07C229/28 ,  C07F5/003

    摘要： The present invention relates to a paramagnetic polynuclear metal complex having enhanced self-relaxation rate and thermodynamic stability, and more particularly, to a synthetic method of a novel DTPA-bis-amide-histidine ligand and DTPA-bis-amide-aspartic acid ligand, a novel gadolinium complex ([Gd(L)H2O]) using the ligand, and a paramagnetic polynuclear metal complex using the gadolinium complex. The paramagnetic polynuclear metal complex is able to fix three or more metals (one gadolinium and two metal ions), thereby providing more excellent self-relaxation rate than the commercially available contrast agents. Thus, it can be widely applied to an MRI contrast agent because of meeting the high self-relaxation rate required as a contrast agent of magnetic resonance imaging (MRI).

    摘要翻译： 本发明涉及具有增强的自松弛率和热力学稳定性的顺磁性多核金属络合物，更具体地说，涉及新的DTPA-双 - 酰胺 - 组氨酸配体和DTPA-双 - 酰胺 - 天冬氨酸配体的合成方法， 使用配体的新型钆络合物（[Gd（L）H 2 O]）和使用钆络合物的顺磁性多核金属络合物。 顺磁性多核金属络合物能够固定三种或更多种金属（一种钆和两种金属离子），从而提供比市售造影剂更优异的自松弛率。 因此，由于满足作为磁共振成像（MRI）的造影剂所需的高自放松率，可以广泛地应用于MRI造影剂。

    Method of Manufacturing an Air Hole of Hollow Fiber Membrane Module for Water Treatment
    10.
    发明申请
    Method of Manufacturing an Air Hole of Hollow Fiber Membrane Module for Water Treatment 审中-公开
    水处理中空纤维膜模块空气孔的制造方法

    公开(公告)号：US20100276835A1

    公开(公告)日：2010-11-04

    申请号：US11993041

    申请日：2006-06-20

    申请人： Soon Hyuk Im ,  Tae Duog Lee ,  Sung Su Bae ,  Seong Hoe Koo ,  Tae Jeong Kim ,  Sang Hoon Kim ,  Hang Duk Rho ,  Sung Du Leem ,  Yong Hee Yoo ,  Hyung Jin Jun

    发明人： Soon Hyuk Im ,  Tae Duog Lee ,  Sung Su Bae ,  Seong Hoe Koo ,  Tae Jeong Kim ,  Sang Hoon Kim ,  Hang Duk Rho ,  Sung Du Leem ,  Yong Hee Yoo ,  Hyung Jin Jun

    IPC分类号： B32B1/08

    CPC分类号： B01D63/022 ,  B01D63/021 ,  B01D65/08 ,  B01D2321/185 ,  B01D2321/2058 ,  B29C70/72 ,  B29L2031/14

    摘要： The present invention relates to a method of forming air holes in a hollow fiber membrane module for water treatment. A main object of the present invention is to easily form air holes in the potting material injected into the module housing to prevent contamination of the hollow fiber membranes in the module housing. Accordingly, the present invention provides a method of forming air holes in a hollow fiber membrane module for water treatment, in which a plurality of pins and a disc-like plate, to which distal ends of the pins are fit, are disposed at one end portion of the inside of the module housing, the pins and the plate are immersed in the potting material (adhesive agent) during the potting process, the bonding mold is first removed from the module housing after the potting process and the plate is separated from the pins, and simultaneously the rear ends of the pins exposed to the outside are pulled outwardly to be removed from the potting material such that a plurality of air holes are formed at the corresponding empty positions of the potting material from which the pins are removed.

    摘要翻译： 本发明涉及一种在水处理中空纤维膜组件中形成气孔的方法。 本发明的主要目的是在注入模块壳体中的灌封材料中容易地形成气孔，以防止模块壳体中的中空纤维膜被污染。 因此，本发明提供了一种在用于水处理的中空纤维膜组件中形成空气孔的方法，其中销的顶端配合的多个销和盘状板被设置在一端 模块壳体内部的部分，销和板在灌封过程中浸没在灌封材料（粘合剂）中，在灌封过程之后首先从模块壳体中移除粘合模具，并将板与 销，并且同时将暴露于外部的销的后端向外拉出以从灌封材料中移除，使得在灌封材料的相应空的位置处形成多个空气孔，销从其移除。