公开(公告)号：US20130014568A1

公开(公告)日：2013-01-17

申请号：US13180436

申请日：2011-07-11

申请人： Sang-Won Lee ,  Min-Sik Kim ,  Seok-Won Hyung

发明人： Sang-Won Lee ,  Min-Sik Kim ,  Seok-Won Hyung

IPC分类号： G01N30/00

CPC分类号： G01N30/10 ,  G01N30/38 ,  G01N30/465

摘要： A liquid chromatography device includes a sample inlet valve to which a sample to be analyzed is introduced, and a trap valve fluid-communicating with a solid phase extraction column and a reverse phase liquid chromatography column. The device further includes a solvent dividing unit dividing flow of a solvent discharged from the sample inlet valve into the first solvent inlet port and the second solvent inlet port of the trap valve. The liquid chromatography device improves resolution and increases reproducibility by allowing the sample injecting direction and the sample eluting direction to be opposite to each other.

摘要翻译： 液相色谱装置包括导入待分析样品的样品入口阀和与固相萃取柱和反相液相色谱柱流体连通的捕集阀。 该装置还包括溶剂分配单元，将从样品入口阀排出的溶剂的流动分成第一溶剂入口和陷阱阀的第二溶剂入口。 液相色谱装置通过使样品注射方向和样品洗脱方向彼此相反来提高分辨率并提高再现性。

公开(公告)号：US08650936B2

公开(公告)日：2014-02-18

申请号：US13180436

申请日：2011-07-11

申请人： Sang-Won Lee ,  Min-Sik Kim ,  Seok-Won Hyung

发明人： Sang-Won Lee ,  Min-Sik Kim ,  Seok-Won Hyung

IPC分类号： G01N1/00

CPC分类号： G01N30/10 ,  G01N30/38 ,  G01N30/465

摘要： A liquid chromatography device includes a sample inlet valve to which a sample to be analyzed is introduced, and a trap valve fluid-communicating with a solid phase extraction column and a reverse phase liquid chromatography column. The device further includes a solvent dividing unit dividing flow of a solvent discharged from the sample inlet valve into the first solvent inlet port and the second solvent inlet port of the trap valve. The liquid chromatography device improves resolution and increases reproducibility by allowing the sample injecting direction and the sample eluting direction to be opposite to each other.

摘要翻译： 液相色谱装置包括导入待分析样品的样品入口阀和与固相萃取柱和反相液相色谱柱流体连通的捕集阀。 该装置还包括溶剂分配单元，将从样品入口阀排出的溶剂的流动分成第一溶剂入口和陷阱阀的第二溶剂入口。 液相色谱装置通过使样品注射方向和样品洗脱方向彼此相反来提高分辨率并提高再现性。

公开(公告)号：US09435771B2

公开(公告)日：2016-09-06

申请号：US13397409

申请日：2012-02-15

申请人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

发明人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

IPC分类号： G01N30/08 ,  G01N30/20 ,  B01D15/14 ,  B01D15/16

CPC分类号： G01N30/08 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202

摘要： Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump.

摘要翻译： 提供一种用于液相色谱系统的多功能选择阀。 所述多功能选择阀包括多个端口，所述第一尺寸分离柱的两端可以在其一端连接到所述多个端口，所述多功能选择阀包括：流体通过模式，其中导入的流体不通过所述第一尺寸分离柱 但已经出院了 引入其中的流体通过第一维分离柱然后排出的柱通过模式; 以及防止流体被引入的流体阻塞模式。 当使用多功能选择阀时，它会修改色谱溶剂的流路，从而使得多功能液相色谱系统能够通过单个二元泵进行一维分离，二维分离，在线消化和在线磷酸肽浓缩。

公开(公告)号：US20120145617A1

公开(公告)日：2012-06-14

申请号：US13397409

申请日：2012-02-15

申请人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

发明人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

IPC分类号： B01D15/10 ,  G01N30/84 ,  B22D41/16

CPC分类号： G01N30/08 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202

摘要： Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump.

摘要翻译： 提供一种用于液相色谱系统的多功能选择阀。 所述多功能选择阀包括多个端口，所述第一尺寸分离柱的两端可以在其一端连接到所述多个端口，所述多功能选择阀包括：流体通过模式，其中导入的流体不通过所述第一尺寸分离柱 但已经出院了 引入其中的流体通过第一维分离柱然后排出的柱通过模式; 以及防止流体被引入的流体阻塞模式。 当使用多功能选择阀时，它会修改色谱溶剂的流路，从而使得多功能液相色谱系统能够通过单个二元泵进行一维分离，二维分离，在线消化和在线磷酸肽浓缩。