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    Multi-functional option valve, multifunctional fully automatic liquid chromatography system including the same, and method for analyzing sample using the same
    1.
    发明授权
    Multi-functional option valve, multifunctional fully automatic liquid chromatography system including the same, and method for analyzing sample using the same 有权
    多功能选择阀，包括其的多功能全自动液相色谱系统和使用其的样品分析方法

    公开(公告)号：US09435771B2

    公开(公告)日：2016-09-06

    申请号：US13397409

    申请日：2012-02-15

    申请人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

    发明人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

    IPC分类号： G01N30/08 ,  G01N30/20 ,  B01D15/14 ,  B01D15/16

    CPC分类号： G01N30/08 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202

    摘要： Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump.

    摘要翻译： 提供一种用于液相色谱系统的多功能选择阀。 所述多功能选择阀包括多个端口，所述第一尺寸分离柱的两端可以在其一端连接到所述多个端口，所述多功能选择阀包括：流体通过模式，其中导入的流体不通过所述第一尺寸分离柱 但已经出院了 引入其中的流体通过第一维分离柱然后排出的柱通过模式; 以及防止流体被引入的流体阻塞模式。 当使用多功能选择阀时，它会修改色谱溶剂的流路，从而使得多功能液相色谱系统能够通过单个二元泵进行一维分离，二维分离，在线消化和在线磷酸肽浓缩。

    MULTI-FUNCTIONAL OPTION VALVE, MULTIFUNCTIONAL FULLY AUTOMATIC LIQUID CHROMATOGRAPHY SYSTEM INCLUDING THE SAME, AND METHOD FOR ANALYZING SAMPLE USING THE SAME
    2.
    发明申请
    MULTI-FUNCTIONAL OPTION VALVE, MULTIFUNCTIONAL FULLY AUTOMATIC LIQUID CHROMATOGRAPHY SYSTEM INCLUDING THE SAME, AND METHOD FOR ANALYZING SAMPLE USING THE SAME 有权
    多功能选择阀，包括其的多功能全自动液相色谱系统和使用其分析样品的方法

    公开(公告)号：US20120145617A1

    公开(公告)日：2012-06-14

    申请号：US13397409

    申请日：2012-02-15

    申请人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

    发明人： Sang-Won Lee ,  Seok-Won Hyung ,  Jung Hwa Lee ,  Kyong-Chul Kim ,  Dong-Gi Mun

    IPC分类号： B01D15/10 ,  G01N30/84 ,  B22D41/16

    CPC分类号： G01N30/08 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202

    摘要： Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump.

    摘要翻译： 提供一种用于液相色谱系统的多功能选择阀。 所述多功能选择阀包括多个端口，所述第一尺寸分离柱的两端可以在其一端连接到所述多个端口，所述多功能选择阀包括：流体通过模式，其中导入的流体不通过所述第一尺寸分离柱 但已经出院了 引入其中的流体通过第一维分离柱然后排出的柱通过模式; 以及防止流体被引入的流体阻塞模式。 当使用多功能选择阀时，它会修改色谱溶剂的流路，从而使得多功能液相色谱系统能够通过单个二元泵进行一维分离，二维分离，在线消化和在线磷酸肽浓缩。

    DNP63A Gene and Screening Methods of Anticancer Agent by Using it
    5.
    发明申请
    DNP63A Gene and Screening Methods of Anticancer Agent by Using it 有权
    DNP63A基因和抗癌剂的筛选方法

    公开(公告)号：US20100105045A1

    公开(公告)日：2010-04-29

    申请号：US12532267

    申请日：2007-03-30

    申请人： Hyun Sook Lee ,  Jung Hwa Lee

    发明人： Hyun Sook Lee ,  Jung Hwa Lee

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N2333/4748

    摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.

    摘要翻译： 本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质 癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。 此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。

    Temperature detecting circuit
    7.
    发明授权
    Temperature detecting circuit 失效
    温度检测电路

    公开(公告)号：US06967521B2

    公开(公告)日：2005-11-22

    申请号：US10732430

    申请日：2003-12-10

    申请人： Jung Hwa Lee

    发明人： Jung Hwa Lee

    IPC分类号： G01K7/42 ,  G01K3/10 ,  H03K3/42

    CPC分类号： G01K3/10

    摘要： A temperature detecting circuit includes a first delay unit for outputting a reference signal, a second delay unit for outputting a plurality of delay signals, a detecting unit for outputting a plurality of detecting signals according to the reference signal and delay signals, an encoder for encoding the plurality of the detecting signals, a buffer for outputting the output signal of the encoder to the outside and a fuse information from the outside to a select means, and the select unit that can be programmed according to the fuse information, for outputting a plurality of output signals to the detecting means according to a program state.

    摘要翻译： 温度检测电路包括用于输出参考信号的第一延迟单元，用于输出多个延迟信号的第二延迟单元，用于根据参考信号和延迟信号输出多个检测信号的检测单元，用于编码的编码器 多个检测信号，用于将编码器的输出信号输出到外部的缓冲器和从外部到选择装置的熔丝信息，以及可以根据熔丝信息编程的选择单元，用于输出多个 根据程序状态向检测装置输出输出信号。

    Semiconductor memory device having a memory block with a decreased capacitance
    8.
    发明授权
    Semiconductor memory device having a memory block with a decreased capacitance 有权
    具有具有减小的电容的存储块的半导体存储器件

    公开(公告)号：US06498763B2

    公开(公告)日：2002-12-24

    申请号：US09835812

    申请日：2001-04-17

    申请人： Jung Hwa Lee

    发明人： Jung Hwa Lee

    IPC分类号： G11C800

    CPC分类号： G11C5/025

    摘要： A semiconductor memory device includes a plurality of memory cell arrays. Each of the memory cell arrys includes a plurality of memory blocks. A row decoder is located adjacent to the memory cell array. Capacitance of the memory block becomes smaller as the memory block location becomes farther from the row decoder.

    摘要翻译： 半导体存储器件包括多个存储单元阵列。 每个存储器单元包括多个存储块。 行解码器位于存储单元阵列附近。 存储器块的电容随着存储器块位置变得越来越小于行解码器而变小。

    DNP63A gene and screening methods of anticancer agent by using it
    9.
    发明授权
    DNP63A gene and screening methods of anticancer agent by using it 有权
    DNP63A基因和抗癌剂的筛选方法

    公开(公告)号：US08232070B2

    公开(公告)日：2012-07-31

    申请号：US12532267

    申请日：2007-03-30

    申请人： Hyun Sook Lee ,  Jung Hwa Lee

    发明人： Hyun Sook Lee ,  Jung Hwa Lee

    IPC分类号： G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N2333/4748

    摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.

    摘要翻译： 本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质 癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。 此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。