公开(公告)号：US12025593B2

公开(公告)日：2024-07-02

申请号：US17095280

申请日：2020-11-11

Applicant: Waters Technologies Corporation

Inventor： Jason F. Hill ,  Sylvain Gilles Cormier ,  Martin Gilar

IPC: G01N30/20 ,  G01N30/10 ,  G01N30/30 ,  G01N30/34 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/10 ,  G01N30/34 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202

Abstract: Described herein are a selectable flow restriction device and a fluidic network for chromatographic sample dilution during injection. A selectable flow restriction device is used in combination with a splitter to define an adjustable splitter for separating a high-pressure solvent flow into two separate solvent flows having the same solvent composition. The first solvent flow passes to a sample manager where a sample is injected as a discrete fluidic plug at an injection valve into a flow comprising at least one solvent. The second solvent flow is merged downstream from the location of injection with the first solvent carrying the sample fluidic plug. The second solvent flow dilutes the sample plug during the mixture of the two solvent flows.

公开(公告)号：US11982652B2

公开(公告)日：2024-05-14

申请号：US17512160

申请日：2021-10-27

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Sang-Won Lee ,  Hangyeore Lee

IPC: G01N30/34 ,  B01D15/08 ,  B01D15/24 ,  B01D15/32 ,  G01N30/02 ,  G01N30/20 ,  G01N30/38 ,  G01N30/46 ,  G01N30/82 ,  G01N30/89

CPC classification number: G01N30/34 ,  B01D15/08 ,  G01N30/82 ,  G01N30/89 ,  B01D15/24 ,  B01D15/325 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N30/38 ,  G01N30/463

Abstract: Disclosed are non-contiguous sample fractionating and concatenating device and a dual online multidimensional liquid chromatography system having the same. The non-contiguous sample fractionating and concatenating device according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.

公开(公告)号：US11852616B2

公开(公告)日：2023-12-26

申请号：US17143618

申请日：2021-01-07

Applicant: SAUDI ARABIAN OIL COMPANY

Inventor： Hana Matouq ,  Mohammed Sajjad Ali

IPC: G01N30/06 ,  G01N30/20 ,  G01N30/88 ,  G01N33/28 ,  G01N25/12 ,  G01N30/02 ,  G01N30/52 ,  B01D3/06 ,  E21B49/08

CPC classification number: G01N30/06 ,  G01N25/12 ,  G01N30/20 ,  G01N30/88 ,  G01N33/2823 ,  B01D3/06 ,  E21B49/088 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/201 ,  G01N2030/522 ,  G01N2030/8854

Abstract: A system includes a phase behavior analysis unit having a housing, a heating system connected to the housing and arranged to heat an interior of the housing, a pressure cell positioned in the interior of the housing, and a three-way valve with one inlet fluidly connected to a chamber in the pressure cell and two outlets. The system also includes a gas chromatograph that is fluidly coupled to the chamber in the pressure cell via the three-way valve.

公开(公告)号：US11835496B2

公开(公告)日：2023-12-05

申请号：US17126236

申请日：2020-12-18

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson

IPC: G01N30/24 ,  G01N30/20 ,  G01N30/36 ,  G01N30/02

CPC classification number: G01N30/24 ,  G01N30/20 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202

Abstract: A method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow include a metering pump module, a sample needle, a needle seal and an injection valve. The metering pump module includes a metering pump and a pressure transducer in serial fluidic communication. When the injection valve is in a first valve state, the injection valve is configured to fluidically terminate ports of the metering pump module. When the injection valve is in a second valve state, the injection valve is configured to fluidically couple a fluidic path that includes the metering pump module and sample needle into the system flow of a chromatography system without resulting in a substantial change in the pressure of the system flow.

公开(公告)号：US11802854B2

公开(公告)日：2023-10-31

申请号：US17508256

申请日：2021-10-22

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann Hochgraeber

IPC: G01N30/20 ,  G01N30/32 ,  G01N35/10 ,  G01N30/24 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N35/1097 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US11781660B2

公开(公告)日：2023-10-10

申请号：US17041375

申请日：2019-03-04

Applicant: Shimadzu Corporation

Inventor： Kazuma Maeda

IPC: F16K11/074 ,  G01N30/20 ,  F16K31/04

CPC classification number: F16K11/0743 ,  G01N30/20 ,  F16K31/041 ,  G01N2030/201 ,  G01N2030/202

Abstract: A multiport valve used for a water quality analyzer is provided with: a valve head having a plurality of ports for receiving pipings for connections therebetween, the ports being provided on an outer surface of the valve head, the valve head including a connection surface in which ends of flow paths communicating with the respective ports are arranged in the same plane, the valve head being made of a resin material having corrosion resistance against a chemical used in the water quality analyzer; a rotor having a flat surface provided with a groove for switching a connection state between the ends of the flow paths arranged on the connection surface, the flat surface being arranged so as to face the connection surface; and a drive mechanism configured to rotate the rotor.

公开(公告)号：US20230236150A1

公开(公告)日：2023-07-27

申请号：US17999201

申请日：2021-05-14

Applicant: Nuctech Company Limited ,  Tsinghua University

Inventor： Qingjun ZHANG ,  Yuanjing LI ,  Zhiqiang CHEN ,  Jianmin LI ,  Weiping ZHU ,  Qiufeng MA ,  Biao CAO ,  Lili YAN ,  Ge LI ,  Nei YANG

IPC: G01N27/622 ,  G01N30/20

CPC classification number: G01N27/622 ,  G01N30/20 ,  G01N2030/025 ,  G01N2030/201

Abstract: A trace detection device including: an ion mobility tube ; a sampling gas path module ; a sample injection gas path module configured to introduce a sample carrier gas containing a sample collected by the sampling gas path module toward the ion mobility tube; and a gas chromatography apparatus capable of pre-separating the sample carrier gas, so as to form a pre-separated sample carrier gas; wherein the sample injection gas path module is further configured to be capable of switching between a first mode and a second mode, in the first mode, the sample injection gas path module introduces the sample carrier gas into the ion mobility tube; and in the second mode, the sample injection gas path module introduces the sample carrier gas into the gas chromatography apparatus to pre-separate the sample carrier gas, and the pre-separated sample carrier gas is introduced into the ion mobility tube.

公开(公告)号：US11703483B2

公开(公告)日：2023-07-18

申请号：US16648296

申请日：2018-09-21

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Lars Olof Nils Rosengren ,  Kerstin Elisabet Erickson ,  Tim Francois

IPC: G01N30/20 ,  G01N30/46 ,  B01D15/18

CPC classification number: G01N30/20 ,  G01N30/468 ,  B01D15/1821 ,  G01N2030/201 ,  G01N2030/205

Abstract: The present invention relates to a valve unit (100) for a chromatography apparatus, the valve unit comprising a fluid inlet (110) configured to receive an input fluid, a fluid outlet (120) configured to provide an output fluid, a first pair of fluid ports (131,132) configured to be coupled to a first column, a second pair (141,142) of fluid ports configured to be coupled to a second column, a coupling valve assembly (200) configured to direct fluid between a selection of the fluid inlet (110), the fluid outlet (120), the first pair of fluid ports (131,132) and the second pair of fluid ports (141,142) in response to one or more control signals, wherein the coupling valve assembly is configured to direct fluid using a selection of membrane valves coupled by fluid channels comprised in a body of the coupling valve assembly. The invention further relates to a chromatography apparatus comprising the valve unit and a membrane valve comprised in the valve unit.

公开(公告)号：US20180080908A1

公开(公告)日：2018-03-22

申请号：US15496956

申请日：2017-04-25

Applicant: Neil R. Picha

Inventor： Neil R. Picha

IPC: G01N30/20 ,  F16K31/04

CPC classification number: G01N30/20 ,  F16K11/076 ,  F16K31/041 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: An injection valve assembly with looping internal sample loop works to inject discrete fluid samples into analytical instrumentation. The assembly provides an internal sample loop that carries the fluid sample follows an outwardly looping path. This looping deposition enables internal sample loop to have a uniform cross section and a larger sample volume of fluid; thereby creating enhanced peak shape in chromatography readings. The assembly provides a stator defined by stator openings, and a rotor defined by rotor grooves. The rotor grooves are arranged to form a rotor circumference. A stator face engages the stator to maintain operational engagement between the stator and the rotor. Internal sample loop is defined by a generally looped shape and an inner tube diameter. Internal sample loop follows a path at least partially outside the rotor circumference; whereby more than half of the length of internal sample loop is outside the rotor circumference.

公开(公告)号：US09841406B2

公开(公告)日：2017-12-12

申请号：US14786397

申请日：2014-04-22

Applicant: Sekisui Medical Co., Ltd.

Inventor： Takuya Yotani ,  Hiroaki Taira ,  Takayuki Oka ,  Hideki Muraki

IPC: G01N30/20 ,  G01N35/10 ,  G01N33/49

CPC classification number: G01N30/20 ,  G01N33/491 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: A switching valve includes: (A) a rotor including: (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including: (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator satisfying the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port.