MODULATION OF LMW-PTPASE EXPRESSION
    1.
    发明申请
    MODULATION OF LMW-PTPASE EXPRESSION 审中-公开
    LMW-PTPASE表达的调控

    公开(公告)号:US20090221671A1

    公开(公告)日:2009-09-03

    申请号:US11915124

    申请日:2006-05-24

    摘要: Disclosed herein are compounds, compositions and methods for modulating the expression of LMW-PTPase in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, and hyperfattyacidemia. In some embodiments, the diabetes is type II diabetes by administration of antisense compounds targeted to LMW-PTPase.

    摘要翻译: 本文公开了用于调节细胞,组织或动物中LMW-PTPase表达的化合物,组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防,改善和/或治疗糖尿病,胰岛素抵抗,胰岛素缺乏,高胆固醇血症,高血糖,血脂异常,高脂血症,高甘油三酯血症和高脂肪酸血症的方法。 在一些实施方案中,通过施用靶向LMW-PTPase的反义化合物,糖尿病是II型糖尿病。

    Compositions and their uses directed to PTPRU
    10.
    发明授权
    Compositions and their uses directed to PTPRU 失效
    组合及其针对PTPRU的用途

    公开(公告)号:US07897583B2

    公开(公告)日:2011-03-01

    申请号:US11915309

    申请日:2006-05-24

    IPC分类号: A61K48/00 C07H21/02 C07H21/04

    摘要: Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.

    摘要翻译: 本文公开了用于调节细胞,组织或动物中PTPRU表达的化合物,组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防,改善和/或治疗糖尿病,肥胖症,胰岛素抵抗,胰岛素缺乏,高胆固醇血症,高血糖症,高脂血症,高甘油三酯血症,高脂肪肝,肝脂肪变性,脂肪性肝炎,非酒精性脂肪性肝炎,代谢综合征,心血管疾病和 通过给予针对PTPRU的反义化合物的冠心病。