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    MODULATION OF LMW-PTPASE EXPRESSION
    1.
    发明申请
    MODULATION OF LMW-PTPASE EXPRESSION 审中-公开
    LMW-PTPASE表达的调控

    公开(公告)号：US20090221671A1

    公开(公告)日：2009-09-03

    申请号：US11915124

    申请日：2006-05-24

    申请人： Sanjay Pandey ,  Robert McKay ,  Sanjay Bhanot ,  Xing-Xian Yu

    发明人： Sanjay Pandey ,  Robert McKay ,  Sanjay Bhanot ,  Xing-Xian Yu

    IPC分类号： A61K31/7088 ,  C07H21/00 ,  A61P3/10

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/03048 ,  C12N2310/3525

    摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMW-PTPase in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, and hyperfattyacidemia. In some embodiments, the diabetes is type II diabetes by administration of antisense compounds targeted to LMW-PTPase.

    摘要翻译： 本文公开了用于调节细胞，组织或动物中LMW-PTPase表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖，血脂异常，高脂血症，高甘油三酯血症和高脂肪酸血症的方法。 在一些实施方案中，通过施用靶向LMW-PTPase的反义化合物，糖尿病是II型糖尿病。

    Modulation of diacylglycerol acyltransferase 2 expression
    3.
    发明授权
    Modulation of diacylglycerol acyltransferase 2 expression 有权
    二酰基甘油酰基转移酶2表达的调控

    公开(公告)号：US08258289B2

    公开(公告)日：2012-09-04

    申请号：US12748281

    申请日：2010-03-26

    申请人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    发明人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    IPC分类号： C07H21/04

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

    摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

    Modulation of diacylglycerol acyltransferase 2 expression
    5.
    发明申请
    Modulation of diacylglycerol acyltransferase 2 expression 失效
    二酰基甘油酰基转移酶2表达的调控

    公开(公告)号：US20050272680A1

    公开(公告)日：2005-12-08

    申请号：US11066725

    申请日：2005-02-24

    申请人： Sanjay Bhanot ,  Kenneth Dobie ,  Xing-Xian Yu ,  Brett Monia

    发明人： Sanjay Bhanot ,  Kenneth Dobie ,  Xing-Xian Yu ,  Brett Monia

    IPC分类号： C07H21/02 ,  C12N15/113 ,  A61K48/00

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

    摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

    MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 2 EXPRESSION
    7.
    发明申请
    MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 2 EXPRESSION 有权
    二乙酰胆碱酯酶2的表达调控

    公开(公告)号：US20130123331A1

    公开(公告)日：2013-05-16

    申请号：US13566674

    申请日：2012-08-03

    申请人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    发明人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

    摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

    Compositions and their uses directed to diacylglycerol acyltransferase 1
    8.
    发明授权
    Compositions and their uses directed to diacylglycerol acyltransferase 1 有权
    组合物及其用于二酰基甘油酰基转移酶的用途1

    公开(公告)号：US08003620B2

    公开(公告)日：2011-08-23

    申请号：US11834640

    申请日：2007-08-06

    申请人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    发明人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12Y203/0102

    摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.

    摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。

    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1
    10.
    发明申请
    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1 失效
    组合物及其用途指向二乙酰胆碱酯酶1

    公开(公告)号：US20120029050A1

    公开(公告)日：2012-02-02

    申请号：US13177457

    申请日：2011-07-06

    申请人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    发明人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    IPC分类号： A61K31/713 ,  A61P1/16

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12Y203/0102

    摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.

    摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。