公开(公告)号：US10668223B2

公开(公告)日：2020-06-02

申请号：US14916834

申请日：2014-09-08

申请人： Sanofi

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： A dose indicating mechanism for a drug delivery device for displaying of a dose of a medicament to be dispensed by the drug delivery device includes an elongated housing extending in an axial direction and having at least a first window and a second window that are spaced apart from each other in axial direction. The dose indicating mechanism further includes a dose indicating sleeve movably disposed in the housing and having at least one dose indication coinciding with the first window to display the size of a dose actually set, and an indicator operably engaged with the dose indicating sleeve and axially displaceable relative to the housing to coincide with the second window for indicating an operational status of the dose indicating mechanism.

公开(公告)号：US10420896B2

公开(公告)日：2019-09-24

申请号：US14916818

申请日：2014-09-08

申请人： Sanofi

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/24

摘要： A drive mechanism of a drug delivery device for dispensing of a dose of a medicament, includes an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in axial distal direction, a drive sleeve rotatably supported in the housing at least in a dose incrementing direction against the action of a spring element, and a ratchet mechanism to rotatably fix the drive sleeve relative to the housing. A first ratchet body has a first and a second ratchet element to alternately engage with a toothed profile of a second ratchet body. One of the first and second ratchet bodies is operably engaged with the housing and wherein the other one of the first and second ratchet bodies is operably engaged with the drive sleeve.

公开(公告)号：US10307541B2

公开(公告)日：2019-06-04

申请号：US14783514

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drive mechanism further includes a last dose sleeve rotatably supported in the housing and being selectively engageable with a dose setting mechanism for setting of a dose, and a last dose member threadedly engaged to the housing, rotatably locked to the last dose sleeve and axially displaceable relative to the last dose sleeve.

公开(公告)号：US10226581B2

公开(公告)日：2019-03-12

申请号：US14783190

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Bjorn Wilden ,  Wolfgang Pelzer

IPC分类号： A61M5/20 ,  A61M5/315 ,  A61M5/31

摘要： The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the piston rod (120), when a maximum dose configuration has been reached.

公开(公告)号：US10076610B2

公开(公告)日：2018-09-18

申请号：US14782655

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20

CPC分类号： A61M5/31541 ,  A61M5/20 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M2005/3154 ,  A61M2205/581 ,  A61M2205/582

摘要： A drive mechanism for a drug delivery device includes an elongated housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. A drive sleeve is rotatably supported in the housing, operably releasable from the piston rod for setting of a dose, and operably engageable with the piston rod for dispensing of the dose. A dose limiting member is engaged with the drive sleeve and engaged with the piston rod in such a way that it is displaced in axial direction relative to the drive sleeve when the drive sleeve rotates relative to the piston rod during a dose setting procedure. At least one stop is configured to engage with the dose limiting member for limiting the axial displacement of the dose limiting member during the dose setting procedure and to impede further displacement of the drive sleeve relative to the piston rod.

公开(公告)号：US20160058949A1

公开(公告)日：2016-03-03

申请号：US14783552

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315

摘要： The present invention relates to a drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the mechanism comprising: a housing (20), a piston rod (120) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in a distal direction (1), a rotatable member (80) arranged on an axially extending axis of rotation (4) in the housing (20), said rotatable member (80) being rotatable in a dose incrementing direction (5) against the action of a spring element (78) and being operably engageable with the piston rod (120) during dose dispensing, a clutch member (150) comprising at least one radially displaceable clutch element (153) to engage with a rim (82) of the rotatable member (80) with variably adjustable strength.

摘要翻译： 本发明涉及用于设置和分配药物剂量的药物输送装置的驱动机构，该机构包括：壳体（20），与活塞（14）可操作地接合的活塞杆（120） 一个用于沿远端方向（1）移动活塞（14）的盒（12），一个位于壳体（20）中轴向延伸的旋转轴线（4）上的可旋转构件（80），所述可旋转构件（80） 可抵抗弹簧元件（78）的作用以剂量递增方向（5）旋转，并且在剂量分配期间可与活塞杆（120）可操作地接合;离合器构件（150），包括至少一个可径向移动的离合器元件 153）以可变的可调强度与可旋转构件（80）的轮辋（82）接合。

公开(公告)号：US20160045667A1

公开(公告)日：2016-02-18

申请号：US14783010

申请日：2014-04-08

申请人： SANOFI

发明人： Björn Wilden ,  Stefan Bayer ,  Philipp Zeitz ,  Wolfgang Pelzer

IPC分类号： A61M5/315

CPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31511 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M2205/581

摘要： The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a dose setting member (120; 220) rotatably arranged at a proximal end of the housing (20) for setting of a dose, a base member (60; 260) having a proximally extending shaft portion (61; 261) at least partially enclosed by the dose setting member (120; 220), a last dose limiting member (140; 240) radially disposed between the dose setting member (120; 220) and the base member (60; 260) and having at least one radial stop (143; 243a, 243b) to limit a rotational displacement of the dose setting member (120; 220) relative to the base member (60; 260), wherein the last dose limiting member (140; 240) is rotatably locked but axially displaceable to one of the base member (60; 260) and the dose setting member (120; 220) and wherein the last dose limiting member (140; 240) is threadedly engaged with the other one of the base member (60; 260) and the dose setting member (120; 220).

摘要翻译： 本发明涉及用于分配药物剂量的药物输送装置的驱动机构，该机构包括：沿轴向方向（1,2）延伸的细长壳体（20），活塞杆（160）至 与柱塞（12）的活塞（14）可操作地接合以沿轴向远端方向（1）移动活塞（14）;剂量设定构件（120; 220），可旋转地布置在壳体（20）的近端处， 用于设定剂量的基部构件（60; 260）具有至少部分地由剂量设定构件（120; 220）封闭的近端延伸的轴部分（61; 261），最后剂量限制构件（140,240） 径向地设置在剂量设定部件（120; 220）和基部部件（60,260）之间并具有至少一个径向止动件（143; 243a，243b），以限制剂量设定部件（120; 220）的旋转位移， 相对于基部构件（60; 260），其中最后的剂量限制构件（140,240）可旋转地锁定，但可轴向移动到开 （60; 260）和所述剂量设定构件（120; 220），并且其中所述最后剂量限制构件（140; 240）与所述基座构件（60,260）和所述剂量设定构件（120; 220）中的另一个螺纹接合; 。

公开(公告)号：US11291774B2

公开(公告)日：2022-04-05

申请号：US14783552

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： The present invention relates to a drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the mechanism comprising: a housing (20), a piston rod (120) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in a distal direction (1), a rotatable member (80) arranged on an axially extending axis of rotation (4) in the housing (20), said rotatable member (80) being rotatable in a dose incrementing direction (5) against the action of a spring element (78) and being operably engageable with the piston rod (120) during dose dispensing, a clutch member (150) comprising at least one radially displaceable clutch element (153) to engage with a rim (82) of the rotatable member (80) with variably adjustable strength.

公开(公告)号：US10105493B2

公开(公告)日：2018-10-23

申请号：US14783535

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a drive wheel (110) axially fixed to the housing (20), engaged with the piston rod (160) and rotatable relative to the housing (20) for driving the piston rod (160) in distal direction (1), a drive sleeve (30) axially displaceable relative to the drive wheel (110) to rotatably engage with the drive wheel (110) in a distal dose dispensing position and to disengage from the drive wheel (110) in a proximal dose setting position, wherein the drive sleeve (30) is rotatably secured to the housing (20) in the proximal dose setting position by means of a ratchet member (32).

公开(公告)号：US10099015B2

公开(公告)日：2018-10-16

申请号：US14783160

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/24

摘要： The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), —a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), —a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), —wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.