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公开(公告)号：US20180093050A1
公开(公告)日：2018-04-05
申请号：US15566372
申请日：2016-04-13
发明人： Alex Stenzler , Steve Han , Arthur Slutsky , Steven Ellis , Noe Zamel , William Alston
IPC分类号： A61M15/00
CPC分类号： A61M15/0013 , A61M15/0021 , A61M15/0061 , A61M15/0066 , A61M2202/064
摘要： A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.
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公开(公告)号：US20180021529A1
公开(公告)日：2018-01-25
申请号：US15646205
申请日：2017-07-11
发明人： James Tibbatts , Robin Craig Cocker , Ben Alexander King , Christopher lain Davidson , Paul Mutti , Alex Stenzler , Steve Han
IPC分类号： A61M15/00
摘要： The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir.
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公开(公告)号：US20180140790A1
公开(公告)日：2018-05-24
申请号：US15566412
申请日：2016-04-13
发明人： Alex Stenzler , Steve Han , Arthur Stutsky , Steven Ellis , Noe Zamel
IPC分类号： A61M15/00
摘要： A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.
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公开(公告)号：US20180093051A1
公开(公告)日：2018-04-05
申请号：US15566351
申请日：2016-04-13
发明人： Alex Stenzler , Steve Han , Arthur Slutsky , Steven Ellis , Noe Zamel , William Alston
CPC分类号： A61M15/0015 , A61M11/001 , A61M15/0021 , A61M15/0028 , A61M15/0086 , A61M15/06 , A61M2202/064
摘要： Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.
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公开(公告)号：US20180147371A1
公开(公告)日：2018-05-31
申请号：US15566426
申请日：2016-04-13
发明人： Alex Stenzler , Steve Han , Arthur Slutsky , Steven Ellis , Noe Zamel , Bildad Nyambura
CPC分类号： A61M15/0003 , A24F47/002 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/064 , A61M2206/18
摘要： A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.
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公开(公告)号：US20170172996A1
公开(公告)日：2017-06-22
申请号：US15452133
申请日：2017-03-07
发明人： Alex Stenzler , Noe Zamel , Arthur Slutsky , Steven Ellis , Steve Han
IPC分类号： A61K31/465 , A61K47/24 , A61K47/26 , A24B15/16 , A61K31/045 , A61K47/46 , A61K47/10 , A61K9/00 , A61K47/18
CPC分类号： A61K31/465 , A24B15/16 , A24B15/167 , A61K9/0075 , A61K31/045
摘要： The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.
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