公开(公告)号：US20180093050A1

公开(公告)日：2018-04-05

申请号：US15566372

申请日：2016-04-13

申请人： Alex Stenzler ,  Sansa Corporation (Barbados) Inc.

发明人： Alex Stenzler ,  Steve Han ,  Arthur Slutsky ,  Steven Ellis ,  Noe Zamel ,  William Alston

IPC分类号： A61M15/00

CPC分类号： A61M15/0013 ,  A61M15/0021 ,  A61M15/0061 ,  A61M15/0066 ,  A61M2202/064

摘要： A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.

公开(公告)号：US20180140790A1

公开(公告)日：2018-05-24

申请号：US15566412

申请日：2016-04-13

申请人： Alex Stenzler ,  Sansa Corporation (Barbados) Inc.

发明人： Alex Stenzler ,  Steve Han ,  Arthur Stutsky ,  Steven Ellis ,  Noe Zamel

IPC分类号： A61M15/00

摘要： A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.

公开(公告)号：US20180093051A1

公开(公告)日：2018-04-05

申请号：US15566351

申请日：2016-04-13

申请人： Alex Stenzler ,  Sansa Corporation (Barbados) Inc.

发明人： Alex Stenzler ,  Steve Han ,  Arthur Slutsky ,  Steven Ellis ,  Noe Zamel ,  William Alston

IPC分类号： A61M15/00 ,  A61M15/06

CPC分类号： A61M15/0015 ,  A61M11/001 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0086 ,  A61M15/06 ,  A61M2202/064

摘要： Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.

公开(公告)号：US20180147371A1

公开(公告)日：2018-05-31

申请号：US15566426

申请日：2016-04-13

申请人： Alex Stenzler ,  Sansa Corporation (Barbados) Inc.

发明人： Alex Stenzler ,  Steve Han ,  Arthur Slutsky ,  Steven Ellis ,  Noe Zamel ,  Bildad Nyambura

IPC分类号： A61M15/00 ,  A61M15/06 ,  A24F47/00

CPC分类号： A61M15/0003 ,  A24F47/002 ,  A61M15/0036 ,  A61M15/0041 ,  A61M15/06 ,  A61M2202/064 ,  A61M2206/18

摘要： A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

公开(公告)号：US20180021529A1

公开(公告)日：2018-01-25

申请号：US15646205

申请日：2017-07-11

申请人： Sansa Corporation (Barbados) Inc.

发明人： James Tibbatts ,  Robin Craig Cocker ,  Ben Alexander King ,  Christopher lain Davidson ,  Paul Mutti ,  Alex Stenzler ,  Steve Han

IPC分类号： A61M15/00

摘要： The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir.

公开(公告)号：US20170172996A1

公开(公告)日：2017-06-22

申请号：US15452133

申请日：2017-03-07

申请人： Sansa Corporation (Barbados) Inc.

发明人： Alex Stenzler ,  Noe Zamel ,  Arthur Slutsky ,  Steven Ellis ,  Steve Han

IPC分类号： A61K31/465 ,  A61K47/24 ,  A61K47/26 ,  A24B15/16 ,  A61K31/045 ,  A61K47/46 ,  A61K47/10 ,  A61K9/00 ,  A61K47/18

CPC分类号： A61K31/465 ,  A24B15/16 ,  A24B15/167 ,  A61K9/0075 ,  A61K31/045

摘要： The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.

公开(公告)号：US08770188B2

公开(公告)日：2014-07-08

申请号：US13077849

申请日：2011-03-31

申请人： Alex Stenzler ,  Steve Han

发明人： Alex Stenzler ,  Steve Han

IPC分类号： A61M15/00

CPC分类号： A61M15/0086 ,  A61M15/0015 ,  A61M15/0018 ,  A61M15/002 ,  A61M15/009 ,  A61M2205/3334

摘要： A metered dose inhaler (MDI) spacer has a body that defines a dose receiving chamber. A proximal end portion coupled between the body and a mouth port through which a metered dose may be inhaled by a user of the MDI spacer. A distal end portion is coupled with the body. A combined one-way and flow rate control valve coupled with the distal end portion is configured for permitting external airflow into and prohibiting internal airflow out of the dose receiving chamber. A collar coupled with the distal end portion is configured for receiving an actuator shaft of a metered dose inhaler and for forming a seal about an aerosol nozzle of the metered dose inhaler such that a metered dose of medication is admissible into the dose receiving chamber via the collar while airflow into and out of the dose receiving chamber via the collar is prohibited.

摘要翻译： 定量吸入器（MDI）间隔物具有限定剂量接收室的主体。 连接在主体和口端口之间的近端部分，计量剂量可由MDI间隔物的使用者吸入。 远端部分与身体联接。 与远端部分结合的组合的单向和流量控制阀构造成允许外部气流进入并阻止内部空气流出剂量接收室。 与远端部分联接的套环被构造成用于接收计量剂量吸入器的致动器轴并且用于围绕计量剂量吸入器的气溶胶喷嘴形成密封，使得计量剂量的药物可以经由 在通过衣领进入和离开剂量接收室的气流被禁止的情况下。

公开(公告)号：US08100125B2

公开(公告)日：2012-01-24

申请号：US11241303

申请日：2005-09-30

申请人： Steven Duquette ,  Alex Stenzler ,  Steve Han

发明人： Steven Duquette ,  Alex Stenzler ,  Steve Han

IPC分类号： A61M11/00

CPC分类号： A61M16/0666 ,  A61M16/0012 ,  A61M16/0858

摘要： Provided is a universal interface adapted for providing continuous positive airway pressure to a patient when the interface is used with a standard ventilator. The interface is configured to operate at a supply pressure no greater than about 120 centimeters of H2O in order to deliver pressure to the patient of up to about 15 cm of H2O at a flow rate of up to about 12 liters/minute. The universal interface may comprise an interface body having a space pair of breathing passageways intersecting a corresponding of supply passageways. Each one of the breathing passageways is comprised of a patient passageway and an exhalation passageway. Each one of the supply passageways includes a jet venturi having a taper portion. Each one of the exhalation passageways includes a taper portion which tapers outwardly along a direction from the patient passageway toward the exhalation passageway.

摘要翻译： 提供了一种通用接口，其适于在接口与标准通气机一起使用时向患者提供持续的正气道压力。 该界面构造成在不超过约120厘米H 2 O的供应压力下操作，以便以高达约12升/分钟的流速向患者输送高达约15cm H 2 O的压力。 通用接口可以包括具有与供应通道相对应的空间对的呼吸通道的接口体。 每个呼吸通道由患者通道和呼气通道组成。 每个供应通道包括具有锥形部分的喷射文丘里管。 每个呼气通道包括锥形部分，其沿着从患者通道朝向呼气通道的方向向外变细。

公开(公告)号：US09010321B2

公开(公告)日：2015-04-21

申请号：US13328602

申请日：2011-12-16

申请人： Alex Stenzler ,  Steve Han

发明人： Alex Stenzler ,  Steve Han

IPC分类号： A62B7/10 ,  A62B19/00 ,  A62B23/02 ,  F24J3/00 ,  A61M16/10

CPC分类号： A61M16/1055 ,  A61M16/1065 ,  A61M16/1075 ,  A61M16/1095 ,  A61M2205/3653 ,  A61M2205/584 ,  A61M2205/7509 ,  A61M2205/7518 ,  A61M2205/7536

摘要： A system for keeping moisture in a vapor phase and for removing particles from a gas is described. The system includes a filter and a heating chamber. The filter is capable of being heated and includes a mechanical element that effectively regulates the heating of the filter. Heat production of the heating chamber is coupled to the proper insertion of the filter into the chamber, such that the filter closes an electrical switch in the heating chamber to allow for the production of heat. An exemplary use of the system is the keeping moisture in a vapor phase and removing pathogenic particles from the exhalation path of a ventilated subject.

摘要翻译： 描述了一种用于保持气相中的水分并从气体中除去颗粒的系统。 该系统包括一个过滤器和一个加热室。 过滤器能够被加热并且包括有效地调节过滤器的加热的机械元件。 加热室的热产生耦合到过滤器适当地插入室中，使得过滤器关闭加热室中的电开关以允许产生热量。 该系统的示例性用途是将水分保持在气相中并从通气对象的呼出路径除去致病颗粒。

公开(公告)号：US08932261B2

公开(公告)日：2015-01-13

申请号：US12511395

申请日：2009-07-29

申请人： Alex Stenzler ,  Steve Han

发明人： Alex Stenzler ,  Steve Han

IPC分类号： A61M39/00 ,  A61M16/20 ,  A61M16/00 ,  A62B9/02 ,  A61M16/04 ,  A61M16/08 ,  A61M39/04 ,  A61M39/10

CPC分类号： A61M16/0463 ,  A61M16/0066 ,  A61M16/0465 ,  A61M16/0816 ,  A61M16/208 ,  A61M39/045 ,  A61M2039/1077

摘要： An adapter assembly including a manifold and a valve assembly. The valve assembly includes a seat and a valve body having a circular base and a wall. The wall extends from a trailing side of the base to form a dome-like shape terminating at an end at which a slit is formed, with the wall defining opposing sealing edges at the slit. The seat has an upper circumferential surface and a lower circumferential surface. The upper surface engages a leading side of the base, whereas the lower surface engages a trailing side. At least one of the upper and lower surfaces forms a segment of increased height. Upon final assembly, the valve body is disposed across a passageway of the manifold, with the slit providing a selectively openable path. A force imparted by the segment of increased height flexes the base and biases the sealing edges into engagement.

摘要翻译： 一种包括歧管和阀组件的适配器组件。 阀组件包括座和具有圆形底座和壁的阀体。 壁从底座的后侧延伸以形成圆顶状，其终止于形成狭缝的端部，其中壁在狭缝处限定相对的密封边缘。 座椅具有上周面和下周面。 上表面接合基座的前侧，而下表面接合尾部。 上表面和下表面中的至少一个形成增加高度的段。 在最终组装时，阀体跨越歧管的通道布置，狭缝提供可选择的可开启路径。 由增加的高度段施加的力使基部弯曲并且将密封边缘偏压成接合。