公开(公告)号：US09302967B2

公开(公告)日：2016-04-05

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： A61K31/14 ,  A61K31/05 ,  C07C39/19 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US20140135393A1

公开(公告)日：2014-05-15

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： C07C39/19 ,  C07C251/40 ,  C07D317/50 ,  C07C255/36 ,  C07C69/732 ,  C07C69/017 ,  C07C251/66

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。