专利检索 ap:("Santu Bandyopadhyay" OR "Balaram Ghosh" OR "Parasuraman Jaisankar" OR "Bikas Chandra Pal" OR "Siddhartha Roy" OR "Bholanath Paul" OR "Arjun Ram" OR "Ulaganathan Mabalirajan" OR "Nahid Ali" OR "Arun Bandopadhyay" OR "Aditya Konar" OR "Jayashree Bagchi Chakraborty" OR "Indrani Choudhury Mukherjee" OR "Jaydeep Chaudhuri" OR "Sanjit Kumar Mahato" OR "Anirban Manna" OR "Roma Sinha" OR "Pradyot Bhattacharya" OR "Jayaraman Vinayagam" OR "Deba Prasad Jana" OR "Sushovan Chowdhury") AND inv:"Bholanath Paul" 第 1 页

1.

发明授权
Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma 有权
标题翻译：取代的导管胆固醇作为IL-4和IL-5的抑制剂用于治疗支气管哮喘

公开(公告)号：US09302967B2

公开(公告)日：2016-04-05

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Choudhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Pradyot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury

发明人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Choudhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Pradyot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury

IPC分类号： A61K31/14 , A61K31/05 , C07C39/19 , A61K31/15 , A61K31/215 , A61K31/277 , A61K31/36 , C07C69/017 , C07C69/732 , C07C251/40 , C07C251/66 , C07C255/36 , C07D317/50

CPC分类号： C07C39/19 , A61K31/05 , A61K31/15 , A61K31/215 , A61K31/277 , A61K31/36 , C07C69/017 , C07C69/732 , C07C251/40 , C07C251/66 , C07C255/36 , C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。通式1的化合物可用于减少血管周围和支气管炎。

2.

发明申请
SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA 审中-公开
标题翻译：作为IL-4和IL-5的抑制剂作为治疗性胆碱性哮喘的替代物

公开(公告)号：US20140135393A1

公开(公告)日：2014-05-15

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Balaram Ghosh , Parasuraman Jaisankar , Bikas Pal , Nahid Ali , Siddhartha Roy , Bholanath Paul , Arjun Ram , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Chowdhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Prayot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury

发明人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Balaram Ghosh , Parasuraman Jaisankar , Bikas Pal , Nahid Ali , Siddhartha Roy , Bholanath Paul , Arjun Ram , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Chowdhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Prayot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury

IPC分类号： C07C39/19 , C07C251/40 , C07D317/50 , C07C255/36 , C07C69/732 , C07C69/017 , C07C251/66

CPC分类号： C07C39/19 , A61K31/05 , A61K31/15 , A61K31/215 , A61K31/277 , A61K31/36 , C07C69/017 , C07C69/732 , C07C251/40 , C07C251/66 , C07C255/36 , C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。通式1的化合物可用于减少血管周围和支气管炎。

3.

发明授权
Method for treatment of bronchial asthma 有权
标题翻译：治疗支气管哮喘的方法

公开(公告)号：US08519154B2

公开(公告)日：2013-08-27

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata Mukhopadhyay , Mumu Chakraborty , Tulika Mukherjee , Arun Bandyopadhyay , Dipak Kar , Tanima Banerjee , Aditya Konar , Debaprasad Jana , Siddhartha Roy , Santu Bandyopadhyay , Balram Ghosh , Mabalirajan Ulaganathan , Rakesh Kamal Johri , Subhash Chander Sharma , Gurdarshan Singh , Bholanath Paul , Vasanta Madhava Sharma Gangavaram , Jhillu Singh Yadav , Radha Krishna Palakodety

发明人： Sibabrata Mukhopadhyay , Mumu Chakraborty , Tulika Mukherjee , Arun Bandyopadhyay , Dipak Kar , Tanima Banerjee , Aditya Konar , Debaprasad Jana , Siddhartha Roy , Santu Bandyopadhyay , Balram Ghosh , Mabalirajan Ulaganathan , Rakesh Kamal Johri , Subhash Chander Sharma , Gurdarshan Singh , Bholanath Paul , Vasanta Madhava Sharma Gangavaram , Jhillu Singh Yadav , Radha Krishna Palakodety

IPC分类号： C07D209/82 , C07D209/88 , A61K31/403

CPC分类号： C07D209/86 , A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药路线以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。