公开(公告)号：US09302967B2

公开(公告)日：2016-04-05

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： A61K31/14 ,  A61K31/05 ,  C07C39/19 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US20140135393A1

公开(公告)日：2014-05-15

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： C07C39/19 ,  C07C251/40 ,  C07D317/50 ,  C07C255/36 ,  C07C69/732 ,  C07C69/017 ,  C07C251/66

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US20120190738A1

公开(公告)日：2012-07-26

申请号：US13144263

申请日：2010-01-12

申请人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

发明人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC分类号： A61K31/36 ,  A61K31/225 ,  C07C215/54 ,  A61K31/138 ,  C07C255/33 ,  A61P35/02 ,  A61K31/15 ,  C07D317/50 ,  C07C39/10 ,  A61K31/05 ,  A61P35/00 ,  C07C69/353 ,  A61K31/277

CPC分类号： C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

摘要： The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

摘要翻译： 本发明涉及通过抑制PI3-Akt途径或诱导NO而治疗恶性肿瘤的通式I化合物。 本发明还涉及通式I的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

公开(公告)号：US09290473B2

公开(公告)日：2016-03-22

申请号：US13144263

申请日：2010-01-12

申请人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

发明人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC分类号： A61K31/36 ,  C07C215/54 ,  C07C255/33 ,  C07C39/10 ,  C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

CPC分类号： C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

摘要： The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

摘要翻译： 本发明涉及用于通过抑制PI3-Akt途径和或诱导NO来治疗恶性肿瘤的通式1的化合物。 本发明还涉及通式1的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。