公开(公告)号：US20240277900A1

公开(公告)日：2024-08-22

申请号：US18646092

申请日：2024-04-25

申请人： Satellite Biosciences, Inc.

发明人： Arnav CHHABRA ,  Amanda CHEN ,  Keval N. VYAS ,  Thomas Jay LOWERY, JR. ,  Fabiola MUNARIN ,  Glenn Michael LA MURAGLIA, II ,  Timothy Alfred NORMAN, JR. ,  Christopher Garrison WILSON ,  Joseph E. MARTURANO ,  Morgan JAMIEL ,  Alison HAYWARD ,  Howard TAKIFF

IPC分类号： A61L27/38 ,  A61F2/02 ,  A61L27/22 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61L27/3839 ,  A61F2/022 ,  A61L27/225 ,  A61L27/3813 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/28

摘要： The present disclosure provides engineered tissue constructs having hepatocytes and stromal cells and methods of making and using the same (e.g., for treating acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof). The engineered tissue constructs may provide a microenvironment that promotes the persistence of hepatocyte survival for at least three months.

公开(公告)号：US20230132318A1

公开(公告)日：2023-04-27

申请号：US17827128

申请日：2022-05-27

申请人： Satellite Biosciences, Inc.

发明人： Laura LANDE-DINER ,  Howard TAKIFF ,  Amanda CHEN ,  Arnav CHHABRA ,  Thomas Jay LOWERY, JR. ,  Morgan JAMIEL ,  Alison HAYWARD ,  Timothy Alfred NORMAN, JR. ,  Joseph E. MARTURANO

IPC分类号： A61L27/38 ,  A61L27/22

摘要： The present disclosure provides engineered tissue constructs having a population of cells, such as hepatocytes and stromal cells, and methods of making and using the same (e.g., for treating a disease or disorder, such as acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof).