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公开(公告)号：US06858009B2
公开(公告)日：2005-02-22
申请号：US10333134
申请日：2001-05-16
申请人： Satoshi Kawata , Tadao Sugiura , Osamu Ohshiro , Kunihiro Chihara
发明人： Satoshi Kawata , Tadao Sugiura , Osamu Ohshiro , Kunihiro Chihara
CPC分类号： A61B8/06 , A61B5/0261 , A61B5/0263 , A61B8/12
摘要： An ultrasonic angioscope system which uses an imaging technique of sending ultrasonic waves to a portion ahead of a stricture of a blood vessel and visualizing a portion in the forward direction of the angioscope, and which uses a laser breakdown is provided. The ultrasonic angioscope system includes: a laser generating device (11) installed outside the human body; a probe (20) that introduces laser beams (13) emitted from the laser generating device (11) into a blood vessel (1) via an optical fiber (12), is set at the tip of the optical fiber (12), and has a lens (14) and a water tank (15) as a dielectric; ultrasonic-wave generating means that uses a laser breakdown (16) produced in the water tank (15); a plurality of hydrophones (18) that receive reflected waves, of ultrasonic waves emitted by the laser breakdown (16), from a stricture portion (2) of a blood vessel (1), and are disposed at the tip end of the probe (20); and means of forming a stricture-shaped image of the stricture portion (2) based on the signals received from the hydrophones (18) by a synthetic aperture method.
摘要翻译： 提供一种超声波血管造影仪系统，其使用将超声波发送到血管狭窄前方的部分并使血管镜向前方的部分可视化并使用激光击穿的成像技术。 超声波血管造影仪系统包括：安装在人体外部的激光发生装置（11） 将从激光发生装置（11）发射的激光束（13）经由光纤（12）引入血管（1）的探针（20）设置在光纤（12）的前端，并且 具有作为电介质的透镜（14）和水箱（15） 使用在水箱（15）中产生的激光击穿（16）的超声波发生装置; 从血管（1）的狭窄部分（2）接收由激光击穿（16）发射的超声波的反射波的多个水听器（18），并设置在探针的末端 20）; 以及基于从水听器（18）接收的信号通过合成孔径法形成狭缝部分（2）的狭窄形状图像的装置。
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公开(公告)号：US08384044B2
公开(公告)日：2013-02-26
申请号：US12527780
申请日：2007-08-27
申请人： Tadao Sugiura , Masato Mori , Eiji Inamoto
发明人： Tadao Sugiura , Masato Mori , Eiji Inamoto
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6452 , G01N21/6458
摘要： It is an objection of the present invention to provide a fluorescence reading apparatus in view of the influence of fluorescence derived from a fluorescence substance that is not involved with an interaction between a probe substance and a target substance.The above-mentioned problem is solved by a fluorescence reading apparatus 12 comprising an incidence angle adjusting means 10 for adjusting an incidence angle when light from a light source 7 is incident on a substrate 2; and a controller 11 that controls an amount of the incidence angle adjusted by the incidence angle adjusting means 10 and also comprises a means for receiving information on the incidence angle and information on the fluorescence intensities or fluorescence images at a plurality of incidence angles and obtaining the penetration depths of the evanescent fields with respect to the plurality of incidence angles from the information on the incidence angles; and a means for obtaining information on the fluorescence intensities in the obtained plurality of penetration depths.
摘要翻译： 考虑到不涉及探针物质和目标物质之间的相互作用的荧光物质的荧光的影响，本发明的目的是提供一种荧光读取装置。 通过荧光读取装置12解决上述问题，该装置12包括入射角调整装置10，用于当来自光源7的光入射到基板2上时调节入射角; 以及控制器11，其控制由入射角调节装置10调节的入射角的量，并且还包括用于接收关于入射角的信息和关于荧光强度的信息或多个入射角的荧光图像的信息的装置，并获得 相对于入射角度的信息，相对于多个入射角的渐逝场的穿透深度; 以及获得所获得的多个穿透深度中的荧光强度的信息的手段。
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公开(公告)号：US20100140503A1
公开(公告)日：2010-06-10
申请号：US12527780
申请日：2007-08-27
申请人： Tadao Sugiura , Masato Mori , Eiji Inamoto
发明人： Tadao Sugiura , Masato Mori , Eiji Inamoto
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6452 , G01N21/6458
摘要： It is an objection of the present invention to provide a fluorescence reading apparatus in view of the influence of fluorescence derived from a fluorescence substance that is not involved with an interaction between a probe substance and a target substance.The above-mentioned problem is solved by a fluorescence reading apparatus 12 comprising an incidence angle adjusting means 10 for adjusting an incidence angle when light from a light source 7 is incident on a substrate 2; and a controller 11 that controls an amount of the incidence angle adjusted by the incidence angle adjusting means 10 and also comprises a means for receiving information on the incidence angle and information on the fluorescence intensities or fluorescence images at a plurality of incidence angles and obtaining the penetration depths of the evanescent fields with respect to the plurality of incidence angles from the information on the incidence angles; and a means for obtaining information on the fluorescence intensities in the obtained plurality of penetration depths.
摘要翻译： 考虑到不涉及探针物质和目标物质之间的相互作用的荧光物质的荧光的影响，本发明的目的是提供一种荧光读取装置。 通过荧光读取装置12解决上述问题，该装置12包括入射角调整装置10，用于当来自光源7的光入射到基板2上时调节入射角; 以及控制器11，其控制由入射角调节装置10调节的入射角的量，并且还包括用于接收关于入射角的信息和关于荧光强度的信息或多个入射角的荧光图像的信息的装置，并获得 相对于入射角度的信息，相对于多个入射角的渐逝场的穿透深度; 以及获得所获得的多个穿透深度中的荧光强度的信息的手段。
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公开(公告)号：US07957058B2
公开(公告)日：2011-06-07
申请号：US11993020
申请日：2006-06-30
CPC分类号： G02B21/082 , G02B5/3066
摘要： A microscope for introducing light from a light source via an objective lens to a sample so that a user observes the sample via the objective lens includes: a minute opening arranged in an optical path between the light source and the objective lens and on a focal plane of the image side of the objective lens or at a position conjugate with its conjugate plane; position adjusting means for adjusting the position of the minute opening so that the light from the light source via the minute opening is incident to the sample at the Brewster's angle; an polarizing element arranged in the optical path between the light source and the objective lens for extracting rectilinear polarized light from the light from the light source and applying the rectilinear polarized light to the sample.
摘要翻译： 一种用于将来自光源的光经由物镜引入样品的显微镜，以使得用户通过物镜观察样品包括：布置在光源和物镜之间的光路上的微小开口和焦平面 的物镜的像侧或与其共轭平面共轭的位置; 位置调节装置，用于调节微小开口的位置，使得来自光源的光经由分钟开口以布鲁斯特角入射到样品; 布置在光源和物镜之间的光路中的偏振元件，用于从来自光源的光提取直线偏振光，并将直线偏振光施加到样本。
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公开(公告)号：US20080139395A1
公开(公告)日：2008-06-12
申请号：US10591147
申请日：2005-03-04
申请人： Ryoichi Imanaka , Kotaro Minato , Tadao Sugiura
发明人： Ryoichi Imanaka , Kotaro Minato , Tadao Sugiura
CPC分类号： C40B50/14 , C40B20/02 , C40B60/14 , G01N2035/00158
摘要： A microarray disc characterized in that a substrate is provided with a pregroove and a thin film with an excellent adherence to a probe DNA or protein is disposed at least on the pregroove, and that a liquid drop containing the probe DNA or protein is arranged on a convex part or concave part of the pregroove so that the liquid drop expands in the tangential direction of the pregroove due to the surface tension of the liquid drop and/or in the instance of concave part, due to the restriction by the concave groove wall with any expansion in the direction perpendicular to the groove, and that in the above condition, the probe DNA or protein is immobilized on the substrate.
摘要翻译： 一种微阵列盘，其特征在于，具有预浸槽和对探针具有优异粘附性的薄膜的底物或蛋白质至少设置在预槽上，并且将含有探针DNA或蛋白质的液滴设置在 预凹槽的凸部或凹部，使得由于液滴的表面张力和/或在凹部的情况下，由于凹槽壁的限制，液滴在预制槽的切线方向上膨胀， 在垂直于凹槽的方向上的任何扩展，以及在上述条件下，将探针DNA或蛋白质固定在基底上。
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公开(公告)号：US20100142038A1
公开(公告)日：2010-06-10
申请号：US11993020
申请日：2006-06-30
CPC分类号： G02B21/082 , G02B5/3066
摘要： A microscope for introducing light from a light source via an objective lens to a sample so that a user observes the sample via the objective lens includes: a minute opening arranged in an optical path between the light source and the objective lens and on a focal plane of the image side of the objective lens or at a position conjugate with its conjugate plane; position adjusting means for adjusting the position of the minute opening so that the light from the light source via the minute opening is incident to the sample at the Brewster's angle; an polarizing element arranged in the optical path between the light source and the objective lens for extracting rectilinear polarized light from the light from the light source and applying the rectilinear polarized light to the sample.
摘要翻译： 一种用于将来自光源的光经由物镜引入样品的显微镜，以使得用户通过物镜观察样品包括：布置在光源和物镜之间的光路上的微小开口和焦平面 的物镜的像侧或与其共轭平面共轭的位置; 位置调节装置，用于调节微小开口的位置，使得来自光源的光经由分钟开口以布鲁斯特角入射到样品; 布置在光源和物镜之间的光路中的偏振元件，用于从来自光源的光提取直线偏振光，并将直线偏振光施加到样本。
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