公开(公告)号：US07560131B2

公开(公告)日：2009-07-14

申请号：US10540065

申请日：2003-12-22

申请人： Satoshi Wanezaki ,  Hideo Araki

发明人： Satoshi Wanezaki ,  Hideo Araki

IPC分类号： A23L1/20

CPC分类号： A61K31/7084 ,  A23L2/52 ,  A23L11/07 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K31/352 ,  C07H17/07 ,  A23V2250/2116

摘要： It is intended to provide a composition containing isoflavones which has a high purity and yet is highly soluble in water in a natural state without adding any solubilizers or subjecting to chemically modification. It is found out that a composition containing isoflavones with a high purity and a high solubility in water can be obtained by extracting soybean hypocotyls with a water-containing alcohol within a specific temperature range, then allowing a synthetic adsorbent resin to adsorb the obtained extract and eluting with a water-containing alcohol at a specific concentration.

摘要翻译： 旨在提供含有异黄酮的组合物，该组合物具有高纯度并且在天然状态下高度可溶于水，而不添加任何增溶剂或进行化学改性。 发现通过用含水醇在特定温度范围内提取大豆下胚轴，然后使合成吸附树脂吸附所获得的提取物，可以获得含有高纯度和高水溶性的异黄酮的组合物 用特定浓度的含水醇洗脱。

公开(公告)号：US07638643B2

公开(公告)日：2009-12-29

申请号：US10507637

申请日：2003-03-11

申请人： Satoshi Wanezaki ,  Shinichi Tsuzaki ,  Hideo Araki

发明人： Satoshi Wanezaki ,  Shinichi Tsuzaki ,  Hideo Araki

IPC分类号： C11B1/00

CPC分类号： A61K31/704 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21172

摘要： It is intended to easily separate saponins from isoflavones extracted from starting soybeans thereby giving highly pure saponins at a high yield on an industrial scale. Saponins can be highly efficiently separated from isoflavones by performing multistage extraction under mild conditions such that malonyl isoflavone glycoside, from among isoflavones contained in the starting soybeans, is not converted into isoflavone glycoside, acetyl isoflavone glycoside or isoflavone aglycon. Thus, highly pure saponins can be obtained at a high yield on an industrial scale.

摘要翻译： 旨在容易地将皂甙与从起始大豆提取的异黄酮分离，从而以工业规模高产率提供高纯度皂苷。 通过在温和条件下进行多级提取，皂甙可以高效地从异黄酮中分离，使得从起始大豆中含有的异黄酮中的丙二酰异黄酮糖苷不转化为异黄酮糖苷，乙酰异黄酮糖苷或异黄酮糖苷配基。 因此，可以高产率在工业规模上获得高纯度皂苷。

公开(公告)号：US20050123662A1

公开(公告)日：2005-06-09

申请号：US10507637

申请日：2003-03-11

申请人： Satoshi Wanezaki ,  Shinichi Tsuzaki ,  Hideo Araki

发明人： Satoshi Wanezaki ,  Shinichi Tsuzaki ,  Hideo Araki

IPC分类号： A23L1/30 ,  A61K31/704 ,  A61P3/04 ,  A61P37/04 ,  A61P39/06 ,  A23P1/00

CPC分类号： A61K31/704 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21172

摘要： It is intended to easily separate saponins from isoflavones extracted from starting soybeans thereby giving highly pure saponins at a high yield on an industrial scale. Saponins can be highly efficiently separated from isoflavones by performing multistage extraction under mild conditions such that malonyl isoflavone glycoside, from among isoflavones contained in the starting soybeans, is not converted into isoflavone glycoside, acetyl isoflavone glycoside or isoflavone aglycon. Thus, highly pure saponins can be obtained at a high yield on an industrial scale.

摘要翻译： 旨在容易地将皂甙与从起始大豆提取的异黄酮分离，从而以工业规模高产率提供高纯度皂苷。 通过在温和条件下进行多级提取，皂甙可以高效地从异黄酮中分离，使得从起始大豆中含有的异黄酮中的丙二酰异黄酮糖苷不转化为异黄酮糖苷，乙酰异黄酮糖苷或异黄酮糖苷配基。 因此，可以高产率在工业规模上获得高纯度皂苷。

公开(公告)号：US07387805B2

公开(公告)日：2008-06-17

申请号：US10559730

申请日：2004-06-24

申请人： Shinichi Tsuzaki ,  Satoshi Wanezaki ,  Hideo Araki

发明人： Shinichi Tsuzaki ,  Satoshi Wanezaki ,  Hideo Araki

IPC分类号： A01N65/00 ,  A01N45/00 ,  C07D307/34

CPC分类号： C11D3/382 ,  A23L33/105 ,  C07H15/256 ,  C07H17/07 ,  C11D3/2096 ,  C11D3/221 ,  C11D3/222

摘要： A flavonoid solubilization agent capable of highly solubilizing flavonoids such as isoflavone, baicalin, rutin and naringin whose solubility is generally low; and a method of effecting the above solubilization. Flavonoids can be solubilized by causing a flavonoid and soybean saponin and/or malonyl isoflavone glycoside to be co-present in an aqueous medium.

摘要翻译： 黄酮类化合物能够高度溶解黄酮类化合物，如异黄酮，黄芩苷，芦丁和柚皮苷，其溶解度一般较低; 以及进行上述增溶的方法。 通过使黄酮类化合物和大豆皂角苷和/或丙二酰异黄酮糖苷共存在水性介质中，可以溶解黄酮。

公开(公告)号：US20070003642A1

公开(公告)日：2007-01-04

申请号：US10540065

申请日：2003-12-22

申请人： Satoshi Wanezaki ,  Hideo Araki

发明人： Satoshi Wanezaki ,  Hideo Araki

IPC分类号： A61K31/7048 ,  A61K36/48 ,  A61K31/353

CPC分类号： A61K31/7084 ,  A23L2/52 ,  A23L11/07 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K31/352 ,  C07H17/07 ,  A23V2250/2116

摘要： It is intended to provide a composition containing isoflavones which has a high purity and yet is highly soluble in water in a natural state without adding any solubilizers or subjecting to chemically modification. It is found out that a composition containing isoflavones with a high purity and a high solubility in water can be obtained by extracting soybean hypocotyls with a water-containing alcohol within a specific temperature range, then allowing a synthetic adsorbent resin to adsorb the obtained extract and eluting with a water-containing alcohol at a specific concentration.

摘要翻译： 旨在提供含有异黄酮的组合物，该组合物具有高纯度并且在天然状态下高度可溶于水，而不添加任何增溶剂或进行化学改性。 发现通过用含水醇在特定温度范围内提取大豆下胚轴，然后使合成吸附树脂吸附所获得的提取物，可以获得含有高纯度和高水溶性的异黄酮的组合物 用特定浓度的含水醇洗脱。