公开(公告)号：US09289606B2

公开(公告)日：2016-03-22

申请号：US12874788

申请日：2010-09-02

申请人： Saurav Paul ,  Troy T. Tegg ,  Israel A. Byrd ,  Riki Thao ,  Harry A. Puryear ,  Linda Nemec ,  John M. Berns

发明人： Saurav Paul ,  Troy T. Tegg ,  Israel A. Byrd ,  Riki Thao ,  Harry A. Puryear ,  Linda Nemec ,  John M. Berns

IPC分类号： A61B18/18 ,  A61N1/32 ,  A61B18/14 ,  A61B18/00

CPC分类号： A61N1/327 ,  A61B18/14 ,  A61B2018/0016

摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.

摘要翻译： 导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。 用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。 光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。 光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。 分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

公开(公告)号：US20120059255A1

公开(公告)日：2012-03-08

申请号：US12874788

申请日：2010-09-02

申请人： Saurav Paul ,  Troy T. Tegg ,  Israel A. Byrd ,  Riki Thao ,  Harry A. Puryear ,  Linda Nemec ,  John M. Berns

发明人： Saurav Paul ,  Troy T. Tegg ,  Israel A. Byrd ,  Riki Thao ,  Harry A. Puryear ,  Linda Nemec ,  John M. Berns

IPC分类号： A61N1/30 ,  A61B18/14 ,  A61B6/00

CPC分类号： A61N1/327 ,  A61B18/14 ,  A61B2018/0016

摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.

摘要翻译： 导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。 用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。 光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。 光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。 分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

公开(公告)号：US20130190754A1

公开(公告)日：2013-07-25

申请号：US13555929

申请日：2012-07-23

申请人： Saurav Paul ,  Harry A. Puryear ,  Riki Thao ,  Hong Cao

发明人： Saurav Paul ,  Harry A. Puryear ,  Riki Thao ,  Hong Cao

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/1206 ,  A61B2018/00023 ,  A61B2018/00577 ,  A61B2018/00875

摘要： The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.

摘要翻译： 本发明涉及双相消融系统。 公开了一种用于消融治疗的双极电极系统，包括压敏导电复合层和一对导电接触或与压敏导电复合层连通的电极。 当施加足够的压力以将压敏导电复合材料转化为电导体时，经由压敏导电组合物递送能量（例如，消融能量）。 还公开了可以包括用于填充材料的通道的电绝缘柔性层。 在一些实施方案中，所述系统也可用于使用双极电极靶向递送化合物，例如药物。

公开(公告)号：US09949792B2

公开(公告)日：2018-04-24

申请号：US13555929

申请日：2012-07-23

申请人： Saurav Paul ,  Harry A. Puryear ,  Riki Thao ,  Hong Cao

发明人： Saurav Paul ,  Harry A. Puryear ,  Riki Thao ,  Hong Cao

IPC分类号： A61B18/14 ,  A61B18/12 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B18/1206 ,  A61B2018/00023 ,  A61B2018/00577 ,  A61B2018/00875

摘要： The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.

公开(公告)号：US20100191142A1

公开(公告)日：2010-07-29

申请号：US12751946

申请日：2010-03-31

申请人： Saurav Paul ,  Todd Stangenes ,  Riki Thao

发明人： Saurav Paul ,  Todd Stangenes ,  Riki Thao

IPC分类号： A61B5/01

CPC分类号： A61B18/1402 ,  A61B5/01 ,  A61B5/015 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2562/0271

摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

摘要翻译： 使用温度感测来识别或评估解剖体或结构的医疗装置包括细长的管状构件，至少一个电极，热传感器和温度响应评估系统或部件。 至少一个电极可以连接到细长管状构件的远端部分，并且一个或多个电极可以被配置成向解剖体或结构的一部分提供能量或热量。 热传感器可以被配置为测量解剖体或结构部分（例如组织或血液池）的热响应。 温度响应评估系统或组件可以耦合到热传感器。 在实施例中，该装置可以包括可容纳诸如针的工具的内腔和端口开口。 还公开了使用温度感测来识别解剖体或结构的方法。

公开(公告)号：US20130261491A1

公开(公告)日：2013-10-03

申请号：US13777556

申请日：2013-02-26

申请人： Saurav Paul ,  Todd R. Stangenes ,  Riki Thao

发明人： Saurav Paul ,  Todd R. Stangenes ,  Riki Thao

IPC分类号： A61B5/01

CPC分类号： A61B18/1402 ,  A61B5/01 ,  A61B5/015 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2562/0271

摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

公开(公告)号：US08388549B2

公开(公告)日：2013-03-05

申请号：US12751946

申请日：2010-03-31

申请人： Saurav Paul ,  Todd Stangenes ,  Riki Thao

发明人： Saurav Paul ,  Todd Stangenes ,  Riki Thao

IPC分类号： A61B5/00

CPC分类号： A61B18/1402 ,  A61B5/01 ,  A61B5/015 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2562/0271

摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

公开(公告)号：US20110022045A1

公开(公告)日：2011-01-27

申请号：US12893707

申请日：2010-09-29

申请人： Hong Cao ,  Riki Thao ,  Saurav Paul

发明人： Hong Cao ,  Riki Thao ,  Saurav Paul

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2090/065

摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. In an exemplary embodiment the assembly includes a catheter shaft and a trio of pressure sensitive capacitive members each of whose electrical resistance varies with a pressure vector applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive capacitive members. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive capacitors.

摘要翻译： 公开了一种用于评估导管组件和组织之间的接触的导管组件。 在示例性实施例中，组件包括导管轴和三个压敏电容构件，每个电阻构件的电阻随着施加到导管组件的压力矢量而变化。 组件还包括至少一个测量端子，以允许测量压敏电容构件的电特性的变化。 组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。 组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。 可选地，组件可以包括导电外层。 还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏电容器有关的制造方法。

公开(公告)号：US09220417B2

公开(公告)日：2015-12-29

申请号：US13777556

申请日：2013-02-26

申请人： Saurav Paul ,  Todd R. Stangenes ,  Riki Thao

发明人： Saurav Paul ,  Todd R. Stangenes ,  Riki Thao

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/053

CPC分类号： A61B18/1402 ,  A61B5/01 ,  A61B5/015 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2562/0271

摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

摘要翻译： 利用温度感测来识别或评估解剖体或结构的医疗装置包括细长的管状构件，至少一个电极，热传感器和温度响应评估系统或部件。 至少一个电极可以连接到细长管状构件的远端部分，并且一个或多个电极可以被配置成向解剖体或结构的一部分提供能量或热量。 热传感器可以被配置为测量解剖体或结构部分（例如组织或血液池）的热响应。 温度响应评估系统或组件可以耦合到热传感器。 在实施例中，该装置可以包括可容纳诸如针的工具的内腔和端口开口。 还公开了使用温度感测来识别解剖体或结构的方法。