摘要:
The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要:
The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要:
This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要:
This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要:
The invention provides a dispute resolution platform comprising servers, software, data, and communication capabilities providing a user interface and systems enabling live settlement, live decisions, and live feedback from a group of users who are not a party to the dispute. The present invention provides an online dispute resolution platform enabling parties to describe their dispute, upload evidence, comments, testimony, affidavits and comments from witnesses through a system which identifies opportunities for settlement and prompts users. The system allows the parties to settle their dispute prior to a live hearing, during a live hearing, or after a live hearing,
摘要:
An intellectual property information search and technology marketing and licensing connection platform is provided. The present invention provides new and valuable information and connections for technology marketing and connections in a web accessible format for registered and non-registered users. Marketing is based on keywords, user actions, search results and other factors. Dynamic patent status determination is integrated into the system and is displayed and used for search result filtering and relevancy. User actions and input are also factors for document relevancy and ranking. The system also provides an improved user interface for reviewing intellectual property information with optimized image size, selectable text, and improved navigation.
摘要:
Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the indole derivatives and use of the derivatives for the treatment of pain.
摘要:
A system and method for validating a given wire or financial transaction to determine if the destination bank or any connecting or correspondent banks have a direct or indirect relationship with an illicit entity and, if an illicit relationship is identified, the system attempts to reroute the transaction along a compliant path. Such indirect illicit relationship may be set to require at least two degrees of separation and may be user or bank defined depending on their risk tolerance. The rerouted compliance path may identify multiple paths and rank and prioritize that paths based on risk tolerance, associated fees of the banking touch points, and can automatically approve reroutes or display paths to the user for selection. Further, the system allows banks to set and can then determine any compliance fee splits amongst all entities that may receive a portion of the fee and any adjustments from any rerouted paths.
摘要:
Disclosed herein are quinazolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
摘要:
The present invention provides a system and method for providing an intellectual property collaboration network for the development and improvement of inventions and technology with inventors being granted equity or an ownership interest in patent arrays or companies which patent, market, license and generate revenue from the developed technology. The present invention provides a unique way of distributing equity to contributing inventors of ideas and owners of patents within the network for those technologies which are grouped and related. The system of the present invention enables inventors to submit ideas, collaborate on projects, advance technology and protect inventions through an intellectual property network which provides inventors equity in companies or patent arrays in exchange for the developments which are then patented, marketed, and licensed with revenue flowing through the companies and patent arrays back to the inventors and other contributors of the system. The system may also be used for existing and donated patents which can be marketed and licensed through the system including granting equity or ownership interest in the patent arrays or companies to owners of the existing or donated patents.