专利检索 ap:("Scott B. Hoyt" OR "Min K. Park" OR "Clare London" OR "Yusheng Xiong" OR "D. Jonathan Bennett" OR "Jiaqiang Cai" OR "Paul Ratcliffe" OR "Andrew Cooke" OR "Emma Carswell" OR "John MacLean" OR "Rohit Saxena" OR "Bheemashankar A. Kulkarni" OR "Archana Gupta") AND inv:"Bheemashankar A. Kulkarni" 第 1 页

1.

发明授权
Aldosterone synthase inhibitors 有权
标题翻译：醛固酮合酶抑制剂

公开(公告)号：US09382226B2

公开(公告)日：2016-07-05

申请号：US13811059

申请日：2011-07-20

申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta

发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta

IPC分类号： C07D401/04 , C07D413/14 , C07D471/04 , A61K31/4375 , A61K31/4439 , A61K31/4184 , A61K31/4709

CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04

摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.

摘要翻译： 本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

2.

发明申请
ALDOSTERONE SYNTHASE INHIBITORS 有权

公开(公告)号：US20130317057A1

公开(公告)日：2013-11-28

申请号：US13811059

申请日：2011-07-20

申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jaiqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta

发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jaiqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta

IPC分类号： C07D401/04 , C07D413/14 , A61K31/4375 , A61K31/4709 , A61K31/4439 , C07D471/04

CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04

摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.

摘要翻译： 本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

3.

发明授权
Pyrazolopyridyl compounds as aldosterone synthase inhibitors 有权
标题翻译：吡唑并吡啶基化合物作为醛固酮合酶抑制剂

公开(公告)号：US09351973B2

公开(公告)日：2016-05-31

申请号：US14346518

申请日：2012-09-17

申请人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni

发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni

IPC分类号： C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61P9/12 , A61P13/12 , A61P9/00 , A61P9/10 , A61P1/16

CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04

摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

摘要翻译： 本发明涉及以下结构式的吡唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

4.

发明授权
Aldosterone synthase inhibitors 有权
标题翻译：醛固酮合酶抑制剂

公开(公告)号：US09073929B2

公开(公告)日：2015-07-07

申请号：US14112945

申请日：2012-04-20

申请人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni

发明人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni

IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/41 , A61K45/06

CPC分类号： C07D487/04 , A61K31/41 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00

摘要： This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

摘要翻译： 本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合成酶。本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。

5.

发明申请
ALDOSTERONE SYNTHASE INHIBITORS 有权

公开(公告)号：US20140045819A1

公开(公告)日：2014-02-13

申请号：US14112945

申请日：2012-04-20

申请人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni

发明人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni

IPC分类号： C07D487/04 , C07D471/04

CPC分类号： C07D487/04 , A61K31/41 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00

摘要： This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

摘要翻译： 本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合成酶。本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。

6.

发明授权
Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases 失效
标题翻译：苯并呋喃化合物，用于治疗和预防丙型肝炎病毒感染和相关疾病的组合物和方法

公开(公告)号：US07666863B2

公开(公告)日：2010-02-23

申请号：US11753145

申请日：2007-05-24

申请人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz

发明人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz

IPC分类号： A61K31/54 , A61K31/53 , C07D307/00 , C07D401/00 , C07D417/00

CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14

摘要： The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

摘要翻译： 本发明涉及苯并呋喃衍生物和类似物，以及含有它们的组合物及其用于治疗或预防与其相关的病毒感染和疾病的用途，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病。

7.

发明授权
Certain pyrazoline derivatives with kinase inhibitory activity 失效
标题翻译：某些具有激酶抑制活性的吡唑啉衍生物

公开(公告)号：US07795249B2

公开(公告)日：2010-09-14

申请号：US12002883

申请日：2007-12-19

申请人： Ruth S. Adams , Matthew Duffey , Alexandra E. Gould , Paul D. Greenspan , Bheemashankar A. Kulkarni , Tricia J. Vos

发明人： Ruth S. Adams , Matthew Duffey , Alexandra E. Gould , Paul D. Greenspan , Bheemashankar A. Kulkarni , Tricia J. Vos

IPC分类号： C07D401/04 , C07D413/14 , C07D409/14 , A61K31/4155 , A61P35/00

CPC分类号： C07D409/14 , C07D401/04 , C07D413/14

摘要： The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.

摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的某些吡唑啉化合物。本发明还提供了使用该组合物治疗各种疾病的药物组合物和方法。