公开(公告)号：US20070078349A1

公开(公告)日：2007-04-05

申请号：US11244434

申请日：2005-10-04

申请人： Scott Ferguson ,  John Fralick ,  Scott Bergeson ,  Justin Peatross

发明人： Scott Ferguson ,  John Fralick ,  Scott Bergeson ,  Justin Peatross

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： G01N21/65 ,  A61B5/0059 ,  A61B2560/0223 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/6419 ,  G01N2021/6421

摘要： A method for measuring a chemical concentration in tissue has two measurement steps. First, generating a first light and illuminating a portion of the tissue with the first light; capturing a first reflected light from the tissue; directing the first reflected light to a plurality of light sensors, each light sensor measuring light at a different wavelength, that wavelength being proximate to a wavelength of an expected Raman shift wavelength for the chemical in the tissue; and obtaining a measurement from each of the light sensors, each measurement being specific to the first reflected light through that light sensor. Second, generating a second light and illuminating a portion of the tissue with the second light; capturing a second reflected light from the tissue; directing the second reflected light to the plurality of light sensors, each light sensor measuring light at a different wavelength that wavelength being proximate to a wavelength of an expected Raman shift wavelength for the chemical in the tissue; and obtaining a measurement from each of the light sensors, each measurement being specific to the second reflected light through that light sensor. The measurements of the first reflected light and the measurements of the second reflected light are used to calculate a concentration of the chemical in the tissue.

摘要翻译： 用于测量组织中化学浓度的方法具有两个测量步骤。 首先，产生第一光并用第一光照射组织的一部分; 从组织捕获第一反射光; 将第一反射光引导到多个光传感器，每个光传感器测量不同波长的光，该波长接近组织中化学物质的预期拉曼位移波长的波长; 并且从每个光传感器获得测量值，每个测量对于通过该光传感器的第一反射光是特定的。 第二，产生第二光并用第二光照射组织的一部分; 从组织捕获第二反射光; 将所述第二反射光引导到所述多个光传感器，每个光传感器测量不同波长的光，所述不同波长的波长接近组织中化学物质的预期拉曼位移波长的波长; 并且从每个光传感器获得测量值，每个测量对于通过该光传感器的第二反射光是特定的。 使用第一反射光的测量和第二反射光的测量来计算组织中化学物质的浓度。

公开(公告)号：US20050197580A1

公开(公告)日：2005-09-08

申请号：US10946367

申请日：2004-09-20

申请人： Scott Ferguson ,  Douglas Stevenson ,  John Fralick ,  Larry Brim ,  Jack Peterson ,  Kelvin Lau ,  Eric Moore ,  Lyle Gunderson

发明人： Scott Ferguson ,  Douglas Stevenson ,  John Fralick ,  Larry Brim ,  Jack Peterson ,  Kelvin Lau ,  Eric Moore ,  Lyle Gunderson

IPC分类号： A61B5/00 ,  A61B6/00

CPC分类号： A61B5/0059 ,  A61B5/1495 ,  A61B2560/0233 ,  G01N21/65

摘要： A method, apparatus, and set of compositions are disclosed for calibrating a bio-photonic scanner. The scanner detects selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a computer, including processor and memory connecting to the scanner, including an illuminator to direct light nondestructively onto tissue in vivo, a detector to detect an intensity of a radiant response of the tissue to the light, and a probe to direct light onto the subject and receive a radiant response back into the detector. The apparatus is calibrated using a synthetic material to mimic the radiant response of live tissue, correcting for background fluorescence and elastic scattering. Dopants in a matrix of synthetic material mimic selected molecular structures of tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film powdered and mixed.

摘要翻译： 公开了用于校准生物光子扫描仪的方法，装置和组合。 扫描仪在体内非破坏性地检测组织的选定分子结构。 该装置可以包括计算机，包括连接到扫描器的处理器和存储器，包括用于将光非破坏性地将光引导到体内的照明器，用于检测组织对光的辐射响应的强度的检测器，以及用于引导 将光照射到被摄体上并接收到辐射响应回到检测器中。 使用合成材料校准装置以模拟活组织的辐射响应，校正背景荧光和弹性散射。 合成材料基质中的掺杂剂模拟组织的选定分子结构。 基质材料包括膨胀化合物，掺杂剂包括生物材料以及K型偏光膜粉末和混合物。

公开(公告)号：US20050197581A1

公开(公告)日：2005-09-08

申请号：US10946572

申请日：2004-09-20

申请人： Scott Ferguson ,  Douglas Stevenson ,  John Fralick ,  Larry Brim ,  Jack Peterson ,  Kelvin Lau ,  Eric Moore ,  Lyle Gunderson

发明人： Scott Ferguson ,  Douglas Stevenson ,  John Fralick ,  Larry Brim ,  Jack Peterson ,  Kelvin Lau ,  Eric Moore ,  Lyle Gunderson

IPC分类号： A61B5/00 ,  A61B6/00

CPC分类号： A61B5/0059 ,  A61B5/1495 ,  A61B2560/0233 ,  G01N21/65

摘要： Methods, apparatus, and compositions calibrate a bio-photonic scanner detecting selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a processor, memory, and scanner. The scanner directs light nondestructively onto tissue in vivo, then receives back a radiant response through a system of mirrors and lenses back into the detector. Software for controlling the scanner and processing its output may be calibrated using a synthetic material to mimic the radiant response of tissue. Calibration may account for background fluorescence and elastic scattering, mimicking skin tissue materials having substantially no Raman scattering response of interest. Dopants may be added to the matrix of white scan material to mimic selected molecular structures in tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film and other materials.

摘要翻译： 方法，装置和组合物校准生物光子扫描仪，在体内非破坏性地检测组织的选定分子结构。 该装置可以包括处理器，存储器和扫描器。 扫描仪将光非破坏性地引导到体内的组织上，然后通过反射镜和透镜系统将辐射响应传回回检测器。 用于控制扫描仪和处理其输出的软件可以使用合成材料来校准，以模拟组织的辐射响应。 校准可以解释背景荧光和弹性散射，模拟基本上没有感兴趣的拉曼散射响应的皮肤组织材料。 可以将掺杂剂添加到白色扫描材料的​​基质中以模拟组织中选定的分子结构。 基质材料包括稀释剂，掺杂剂包括生物材料以及K型偏光膜等材料。

公开(公告)号：US08116842B2

公开(公告)日：2012-02-14

申请号：US12958528

申请日：2010-12-02

申请人： John Fralick ,  Kathy L. Chapman, legal representative ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson

发明人： John Fralick ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  G06F19/00 ,  G16H10/60 ,  G16H40/63

摘要： A process, apparatus, and method for online control and database collection and management of a computerized detection, tracking, and feedback control system. The system tests for nutrients by Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example).

摘要翻译： 一种用于在线控制和数据库采集和管理计算机化检测，跟踪和反馈控制系统的过程，设备和方法。 系统通过对皮肤或其他组织的拉曼散射效应来测试营养物质，以确定皮肤中证明的类胡萝卜素或其他营养物质的含量。 营养物质的血清水平可随时间而显着变化，但随着时间的推移，皮肤组织可能会平均增加营养。 可以用光扫描皮肤和其他组织，以基于皮肤中那些营养物质的拉曼散射影响，产生对皮肤积累的类胡萝卜素或其他营养物的精确测量。 得分可以从适当校准的生物光子扫描仪得到，以反映检测到的营养物（例如类胡萝卜素实例）的平均有效摄取。

公开(公告)号：US20110319730A1

公开(公告)日：2011-12-29

申请号：US12958528

申请日：2010-12-02

申请人： John Fralick ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson ,  Kathy L. Chapman

发明人： John Fralick ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson ,  Kathy L. Chapman

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  G06F19/00 ,  G16H10/60 ,  G16H40/63

摘要： A process, apparatus, and method for online control and database collection and management of a computerized detection, tracking, and feedback control system. The system tests for nutrients by Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example).

摘要翻译： 一种用于在线控制和数据库采集和管理计算机化检测，跟踪和反馈控制系统的过程，设备和方法。 系统通过对皮肤或其他组织的拉曼散射效应来测试营养物质，以确定皮肤中证明的类胡萝卜素或其他营养物质的含量。 营养物质的血清水平可随时间而显着变化，但随着时间的推移，皮肤组织可能会平均增加营养。 可以用光扫描皮肤和其他组织，以基于皮肤中那些营养物质的拉曼散射影响，产生对皮肤积累的类胡萝卜素或其他营养物的精确测量。 得分可以从适当校准的生物光子扫描仪得到，以反映检测到的营养物（例如类胡萝卜素实例）的平均有效摄取。

公开(公告)号：US20050278184A1

公开(公告)日：2005-12-15

申请号：US10865740

申请日：2004-06-10

申请人： John Fralick ,  David Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson

发明人： John Fralick ,  David Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson

IPC分类号： A61B5/00 ,  G06F19/00 ,  G06F17/60

CPC分类号： A61B5/0059 ,  G16H10/60 ,  G16H40/63

摘要： A process, apparatus, and method for online control and database collection and management of a computerized detection, tracking, and feedback control system. The system tests for nutrients by Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example).

摘要翻译： 一种用于在线控制和数据库采集和管理计算机化检测，跟踪和反馈控制系统的过程，设备和方法。 系统通过对皮肤或其他组织的拉曼散射效应来测试营养物质，以确定皮肤中证明的类胡萝卜素或其他营养物质的含量。 营养物质的血清水平可随时间而显着变化，但随着时间的推移，皮肤组织可能会平均增加营养。 可以用光扫描皮肤和其他组织，以基于皮肤中那些营养物质的拉曼散射影响，产生对皮肤积累的类胡萝卜素或其他营养物的精确测量。 得分可以从适当校准的生物光子扫描仪得到，以反映检测到的营养物（例如类胡萝卜素实例）的平均有效摄取。

公开(公告)号：US08117044B2

公开(公告)日：2012-02-14

申请号：US12958506

申请日：2010-12-02

申请人： John Fralick ,  Kathy L. Chapman, legal representative ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson

发明人： John Fralick ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson

IPC分类号： G06Q10/00

CPC分类号： A61B5/0059 ,  G06F19/00 ,  G06Q40/12 ,  G06Q50/22

摘要： A process, apparatus, and method for computerized detection, tracking, and feedback control of nutritional supplements in an animal, including humans relies on Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example). This feedback control is thus much more immediate than any anecdotal, long-term, report of general well being, which would vary so much between individuals as to be nearly impossible to ascertain on an individual level, and difficult, invasive, and expensive to determine individually in a conventional clinical procedure.

摘要翻译： 包括人在内的动物的营养补充剂的计算机检测，跟踪和反馈控制的过程，装置和方法依赖于对皮肤或其他组织的拉曼散射效应，以确定在该皮肤中证明的类胡萝卜素或其他营养物的含量。 营养物质的血清水平可随时间而显着变化，但随着时间的推移，皮肤组织可能会平均增加营养。 可以用光扫描皮肤和其他组织，以基于皮肤中那些营养物质的拉曼散射影响，产生对皮肤积累的类胡萝卜素或其他营养物的精确测量。 得分可以从适当校准的生物光子扫描仪得到，以反映检测到的营养物（例如类胡萝卜素实例）的平均有效摄取。 因此，这种反馈控制比任何轶事，长期的总体福利报告更加直接，这些报告在个人之间将有很大的差异，几乎不可能在个人层面上确定，难以确定，创新性和昂贵性 单独在常规临床程序中。

公开(公告)号：US20110320324A1

公开(公告)日：2011-12-29

申请号：US12958506

申请日：2010-12-02

申请人： John Fralick ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson ,  Kathy L. Chapman

发明人： John Fralick ,  David L. Breiter ,  Jack Peterson ,  Mindy Gilbert ,  Marvin Distel ,  Ryan Newman ,  Joel Erickson ,  Kathy L. Chapman

IPC分类号： G06Q40/00 ,  A61B5/1455

CPC分类号： A61B5/0059 ,  G06F19/00 ,  G06Q40/12 ,  G06Q50/22

摘要： A process, apparatus, and method for computerized detection, tracking, and feedback control of nutritional supplements in an animal, including humans relies on Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example). This feedback control is thus much more immediate than any anecdotal, long-term, report of general well being, which would vary so much between individuals as to be nearly impossible to ascertain on an individual level, and difficult, invasive, and expensive to determine individually in a conventional clinical procedure.

摘要翻译： 包括人在内的动物的营养补充剂的计算机检测，跟踪和反馈控制的过程，装置和方法依赖于对皮肤或其他组织的拉曼散射效应，以确定在该皮肤中证明的类胡萝卜素或其他营养物的含量。 营养物质的血清水平可随时间而显着变化，但随着时间的推移，皮肤组织可能会平均增加营养。 可以用光扫描皮肤和其他组织，以基于皮肤中那些营养物质的拉曼散射影响，产生对皮肤积累的类胡萝卜素或其他营养物的精确测量。 得分可以从适当校准的生物光子扫描仪得到，以反映检测到的营养物（例如类胡萝卜素实例）的平均有效摄取。 因此，这种反馈控制比任何轶事，长期的总体福利报告更加直接，这些报告在个人之间将有很大的差异，几乎不可能在个人层面上确定，难以确定，创新性和昂贵性 单独在常规临床程序中。