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公开(公告)号：US08372602B2
公开(公告)日：2013-02-12
申请号：US13339779
申请日：2011-12-29
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20110183359A1
公开(公告)日：2011-07-28
申请号：US13039459
申请日：2011-03-03
IPC分类号： G01N33/53
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US06576744B1
公开(公告)日：2003-06-10
申请号：US09404641
申请日：1999-09-23
IPC分类号： C07K1452
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07411056B2
公开(公告)日：2008-08-12
申请号：US10715998
申请日：2003-11-18
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20120208236A1
公开(公告)日：2012-08-16
申请号：US13339779
申请日：2011-12-29
IPC分类号： C12P21/06
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US08110372B2
公开(公告)日：2012-02-07
申请号：US13039459
申请日：2011-03-03
IPC分类号： G01N33/53 , G01N33/531 , G01N33/532 , C07K14/00 , C07K14/52
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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7.发明授权公开(公告)号：US06692924B2
公开(公告)日：2004-02-17
申请号：US10414186
申请日：2003-04-14
IPC分类号： G01N3353
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07638286B2
公开(公告)日：2009-12-29
申请号：US11537835
申请日：2006-10-02
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US06803451B2
公开(公告)日：2004-10-12
申请号：US10243072
申请日：2002-09-13
IPC分类号： C07K1452
CPC分类号： C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07923212B2
公开(公告)日：2011-04-12
申请号：US12623651
申请日：2009-11-23
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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