-
1.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US08318793B2
公开(公告)日：2012-11-27
申请号：US12748875
申请日：2010-03-29
IPC分类号： A61K31/40 , C07D209/34 , C07D295/00
CPC分类号： C07D401/04 , C07D491/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
-
2.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20120077840A1
公开(公告)日：2012-03-29
申请号：US13245123
申请日：2011-09-26
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
IPC分类号： A61K31/4709 , C07D471/04 , A61K31/437 , A61P25/28 , A61P25/18 , A61P27/06 , A61P25/16 , A61P25/02 , A61P27/02 , A61P19/02 , A61K31/4375 , C07D401/04 , A61P29/00
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
-
3.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US09266855B2
公开(公告)日：2016-02-23
申请号：US13245123
申请日：2011-09-26
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
IPC分类号： C07D215/20 , A61K31/4709 , C07D401/04 , C07D471/04
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
-
4.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20110003810A1
公开(公告)日：2011-01-06
申请号：US12748875
申请日：2010-03-29
IPC分类号： A61K31/5377 , C07D491/04 , C07D471/04 , C07D487/04 , A61K31/4439 , A61P25/18 , A61P25/28 , A61P25/16 , A61P27/06 , A61P19/02 , A61P25/02 , A61P25/00 , A61P9/00 , A61P29/00
CPC分类号： C07D401/04 , C07D491/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
-
5.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US09090592B2
公开(公告)日：2015-07-28
申请号：US13339884
申请日：2011-12-29
申请人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Carolin Hoft , Wilfried Hornberger
发明人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Carolin Hoft , Wilfried Hornberger
IPC分类号： C07D215/46 , C07D405/14 , C07D401/12 , C07D401/14
CPC分类号： C07D471/04 , A61P25/16 , A61P25/28 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.
摘要翻译： 本发明涉及式I的新型杂环化合物，其中变量如权利要求或描述中所定义，其可用于抑制糖原合酶激酶3（GSK-3），含有该化合物的组合物，其用于制备药物的用途 用于治疗易于用调节，优选抑制糖原合酶激酶3和bgr的活性的化合物治疗的医学疾病;以及治疗易于用调节糖原合酶激酶3和bgr的化合物治疗的医学病症的方法; 使用化合物的活性。
-
![1-(7-(hexahydropyrrolo [3,4-c] pyrrol-2 (1H)-yl) quinolin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3)](/abs-image/US/2013/06/04/US08455648B2/abs.jpg.150x150.jpg)
6.发明授权1-(7-(hexahydropyrrolo [3,4-c] pyrrol-2 (1H)-yl) quinolin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3) 有权1-（7-（六氢吡咯并[3,4-c]吡咯-2（1H） - 基）喹啉-4-基）-3-（吡嗪-2-基）脲衍生物和相关化合物作为糖原合酶激酶3 GSK-3）公开(公告)号：US08455648B2
公开(公告)日：2013-06-04
申请号：US12988833
申请日：2009-04-24
IPC分类号： C07D215/38
CPC分类号： C07D487/04 , C07D487/08 , C07D491/048
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
-
![1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)](/abs-image/US/2011/05/05/US20110105528A1/abs.jpg.150x150.jpg)
7.发明申请1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3) 有权1-（7-（六氢吡喃并[3,4-C]吡咯-2（1H） - 基）喹啉-4-基）-3-（吡嗪-2-基）脲衍生物和相关化合物作为GLYCOGEN SYNTHASE KINASE 3（ GSK-3）公开(公告)号：US20110105528A1
公开(公告)日：2011-05-05
申请号：US12988833
申请日：2009-04-24
IPC分类号： A61K31/497 , C07D403/14 , C07D405/14 , A61K31/4709 , A61P25/18 , A61P25/28 , A61P25/16 , A61P19/02
CPC分类号： C07D487/04 , C07D487/08 , C07D491/048
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
-
8.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20120172376A1
公开(公告)日：2012-07-05
申请号：US13339884
申请日：2011-12-29
申请人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel van Gaalen , Carolin Hoft , Wilfried Hornberger
发明人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel van Gaalen , Carolin Hoft , Wilfried Hornberger
IPC分类号： A61K31/497 , C07D401/12 , C07D401/14 , A61K31/4709 , A61P25/28 , A61P29/00 , A61P25/18 , A61P25/16 , A61P25/00 , A61P25/02 , A61P27/06 , A61P27/02 , A61P19/02 , C07D471/04 , A61K31/444 , C07D405/14
CPC分类号： C07D471/04 , A61P25/16 , A61P25/28 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.
摘要翻译： 本发明涉及式I的新型杂环化合物，其中变量如权利要求或描述中所定义，其可用于抑制糖原合酶激酶3（GSK-3），含有该化合物的组合物，其用于制备药物的用途 用于治疗易于用调节，优选抑制糖原合酶激酶3和bgr的活性的化合物治疗的医学疾病;以及治疗易于用调节糖原合酶激酶3和bgr的化合物治疗的医学病症的方法; 使用化合物的活性。
-
9.发明授权Substituted oxindole derivatives and their use as vasopressin receptor ligands 有权取代的羟吲哚衍生物及其作为血管加压素受体配体的用途公开(公告)号：US08815868B2
公开(公告)日：2014-08-26
申请号：US12521713
申请日：2007-12-28
申请人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： A61K31/506 , A61K31/4545 , C07D401/14
摘要： The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物与其组合的药物及其用于预防和/或治疗疾病的用途。
-
10.发明授权Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy 有权四氢异喹啉，含有它们的药物组合物及其在治疗中的应用公开(公告)号：US08653100B2
公开(公告)日：2014-02-18
申请号：US12933326
申请日：2009-03-31
申请人： Michael Ochse , Udo Lange , Wilfried Braje , Berthold Behl , Wilfried Hornberger , Mario Mezler , Wilhelm Amberg , Charles W. Hutchins
发明人： Michael Ochse , Udo Lange , Wilfried Braje , Berthold Behl , Wilfried Hornberger , Mario Mezler , Wilhelm Amberg , Charles W. Hutchins
IPC分类号： C07D217/00 , A61K31/472
CPC分类号： C07D217/18 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的四氢异喹啉或其生理上耐受的盐。 本发明涉及包含这种四氢异喹啉的药物组合物以及用于治疗目的的这种四氢异喹啉的用途。 四氢异喹啉是GlyT1抑制剂。
-
-
-
-
-
-
-
-
-
搜索结果
115 条记录 (耗时 0.042 秒)
