公开(公告)号：US20060024269A1

公开(公告)日：2006-02-02

申请号：US11193955

申请日：2005-07-29

申请人： Sean Doyle ,  Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Chung Chan

发明人： Sean Doyle ,  Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Chung Chan

IPC分类号： A61K38/20 ,  C07K14/54

CPC分类号： A61K38/20 ,  A61K38/21 ,  A61K47/60 ,  C07K14/54 ,  C07K14/715 ,  C07K14/7155 ,  A61K2300/00

摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.

公开(公告)号：US20070173445A1

公开(公告)日：2007-07-26

申请号：US11548439

申请日：2006-10-11

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K38/20

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

公开(公告)号：US20070048262A1

公开(公告)日：2007-03-01

申请号：US11531646

申请日：2006-09-13

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K38/20

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

公开(公告)号：US20070172452A1

公开(公告)日：2007-07-26

申请号：US11548451

申请日：2006-10-11

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K38/20

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。

公开(公告)号：US20070053874A1

公开(公告)日：2007-03-08

申请号：US11548429

申请日：2006-10-11

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K38/20

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

公开(公告)号：US20050244423A1

公开(公告)日：2005-11-03

申请号：US11098662

申请日：2005-04-04

申请人： Kevin Klucher ,  Wayne Kindsvogel ,  Pallavur Sivakumar ,  Katherine Henderson

发明人： Kevin Klucher ,  Wayne Kindsvogel ,  Pallavur Sivakumar ,  Katherine Henderson

IPC分类号： A61K38/20 ,  A61K38/21 ,  A61K38/57 ,  A61K39/12 ,  A61K39/21 ,  A61K39/29 ,  C07K14/54

CPC分类号： A61K38/20 ,  A61K38/21 ,  A61K38/212 ,  A61K38/57 ,  A61K47/60 ,  C07K14/54 ,  A61K2300/00

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。

公开(公告)号：US20080075693A1

公开(公告)日：2008-03-27

申请号：US11858699

申请日：2007-09-20

申请人： Kevin Klucher ,  Wayne Kindsvogel ,  Pallavur Sivakumar ,  Katherine Henderson

发明人： Kevin Klucher ,  Wayne Kindsvogel ,  Pallavur Sivakumar ,  Katherine Henderson

IPC分类号： A61K38/20 ,  A61P29/00

CPC分类号： A61K38/20 ,  A61K38/21 ,  A61K38/212 ,  A61K38/57 ,  A61K47/60 ,  C07K14/54 ,  A61K2300/00

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。

公开(公告)号：US20070172451A1

公开(公告)日：2007-07-26

申请号：US11548408

申请日：2006-10-11

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K38/20

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

公开(公告)号：US20070128160A1

公开(公告)日：2007-06-07

申请号：US11548417

申请日：2006-10-11

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K38/20

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

公开(公告)号：US20070264228A1

公开(公告)日：2007-11-15

申请号：US11548487

申请日：2006-10-11

申请人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

发明人： Kevin Klucher ,  Pallavur Sivakumar ,  Wayne Kindsvogel ,  Katherine Henderson

IPC分类号： A61K45/00

CPC分类号： A61K47/60 ,  A61K38/20 ,  A61K38/21 ,  C07K14/54 ,  Y02A50/385 ,  Y02A50/393

摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.