公开(公告)号：US20100256418A1

公开(公告)日：2010-10-07

申请号：US12726196

申请日：2010-03-17

申请人： Sebastian Peer SMIDT ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

发明人： Sebastian Peer SMIDT ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

IPC分类号： C07C205/04

CPC分类号： C07C201/12 ,  C07C209/68 ,  C07C211/52 ,  C07C205/12

摘要： A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C-6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R.sup.2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of:3 a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.

摘要翻译： 制备式I取代的联苯的方法，其中取代基定义如下：X是氟或氯; R1是硝基，氨基或NHR3; R2是氰基，硝基，卤素，C1-C6-烷基，C1-C6-6烯基，C1-C6-炔基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6烷基羰基或苯基; R3是C1-C4-烷基，C1-C4-烯基或C1-C4-炔基; n为1,2或3，其中在n为2或3的情况下，R 2基团也可以不同，其包括使其中Hal为卤素且X和R 1的式II化合物与 在碱存在下和选自以下组中的钯催化剂存在下：a）钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态，b）钯在三芳基膦或三烷基膦存在下的盐 作为络合配体或c）金属钯，任选地在三芳基膦或三烷基膦存在下，在溶剂中与二苯基硼酸（III）反应，其中R 2和n如上所定义，其中使用三芳基膦或三烷基膦 可以被替代。

公开(公告)号：US08115012B2

公开(公告)日：2012-02-14

申请号：US12513003

申请日：2007-11-02

申请人： Martin Sukopp ,  Michael Rack ,  Sebastian Peer Smidt ,  Sandra Löhr ,  Michael Keil ,  Jochen Dietz ,  Joachim Rheinheimer ,  Thomas Grote ,  Thomas Zierke ,  Jan Klaas Lohmann

发明人： Martin Sukopp ,  Michael Rack ,  Sebastian Peer Smidt ,  Sandra Löhr ,  Michael Keil ,  Jochen Dietz ,  Joachim Rheinheimer ,  Thomas Grote ,  Thomas Zierke ,  Jan Klaas Lohmann

IPC分类号： C07D231/10 ,  C07F7/08

CPC分类号： C07D231/14

摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula II in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula III R2HN—NH2  (III) in which R2 has one of the meanings given above.

摘要翻译： 本发明涉及制备式Ⅰ的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基等 。 R 2是氢，C 1 -C 4 - 烷基，苄基或苯基，其中a）通式II的化合物，其中X是氟，氯或溴，R 1具有上面给出的含义之一，R 4是C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 2 -C 8 - 烯基，苄基或苯基与通式R 3 n SiCl（4-n）的硅烷化合物反应，其中n为1,2或3，取代基R 3独立地为 选自由C 1 -C 8 - 烷基和苯基组成的组中的一种，以及选自元素周期表第1,2,3,4和12族金属的金属，其氧化还原电位小于-0.7 V，基于正常的氢电极（在25℃和101.325kPa）; 和b）将来自步骤a）的反应混合物与通式III的化合物R2HN-NH2（III）反应，其中R2具有上述含义之一。

公开(公告)号：US20100069646A1

公开(公告)日：2010-03-18

申请号：US12513003

申请日：2007-11-02

申请人： Martin Sukopp ,  Michael Rack ,  Sebastian Peer Smidt ,  Sandra Löhr ,  Michael Keil ,  Jochen Dietz ,  Joachim Rheinheimer ,  Thomas Grote ,  Thomas Zierke ,  Jan Klaas Lohmann

发明人： Martin Sukopp ,  Michael Rack ,  Sebastian Peer Smidt ,  Sandra Löhr ,  Michael Keil ,  Jochen Dietz ,  Joachim Rheinheimer ,  Thomas Grote ,  Thomas Zierke ,  Jan Klaas Lohmann

IPC分类号： C07D231/10 ,  C07F7/08

CPC分类号： C07D231/14

摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula II in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula III R2HN—NH2   (III) in which R2 has one of the meanings given above.

摘要翻译： 本发明涉及制备式Ⅰ的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基等 。 并且R 2是氢，C 1 -C 4 - 烷基，苄基或苯基，其中a）通式II的化合物，其中X是氟，氯或溴，R 1具有上面给出的含义之一，R 4是C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 2 -C 8 - 烯基，苄基或苯基与通式R 3 n SiCl（4-n）的硅烷化合物反应，其中n为1,2或3，取代基R 3独立地为 选自由C 1 -C 8 - 烷基和苯基组成的组中的一种，以及选自元素周期表第1,2,3,4和12族金属的金属，其氧化还原电位小于-0.7 V，基于正常的氢电极（在25℃和101.325kPa）; 和b）将来自步骤a）的反应混合物与通式III的化合物R2HN-NH2（III）反应，其中R2具有上述含义之一。

公开(公告)号：US20090005597A1

公开(公告)日：2009-01-01

申请号：US12087345

申请日：2007-05-31

申请人： Sebastian Peer Smidt ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

发明人： Sebastian Peer Smidt ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

IPC分类号： C07C201/12 ,  C07C209/68

CPC分类号： C07C201/12 ,  C07C209/68 ,  C07C211/52 ,  C07C205/12

摘要： A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of: a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.

摘要翻译： 制备式I取代的联苯的方法，其中取代基定义如下：X是氟或氯; R1是硝基，氨基或NHR3; R2是氰基，硝基，卤素，C1-C6-烷基，C1-C6-烯基，C1-C6-炔基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-烷基羰基或苯基; R3是C1-C4-烷基，C1-C4-烯基或C1-C4-炔基; n为1,2或3，其中在n为2或3的情况下，R2基团也可以不同，其包括使Hal为卤素的化合物与X和R 1如上所定义的化合物反应在 存在碱和钯催化剂，其选自：a）钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态，b）钯在三芳基膦或三烷基膦作为络合配体的存在下的盐，或 c）金属钯，任选地在三芳基膦或三烷基膦存在下，在溶剂中与其中R 2和n如上定义的二苯基硼酸（III）反应，其中所用的三芳基膦或三烷基膦可以被取代。

公开(公告)号：US08030527B2

公开(公告)日：2011-10-04

申请号：US12726196

申请日：2010-03-17

申请人： Sebastian Peer Smidt ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

发明人： Sebastian Peer Smidt ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

IPC分类号： C07C205/06

CPC分类号： C07C201/12 ,  C07C209/68 ,  C07C211/52 ,  C07C205/12

摘要： A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C-6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R.sup.2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of:3 a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.

摘要翻译： 制备式I取代的联苯的方法，其中取代基定义如下：X是氟或氯; R1是硝基，氨基或NHR3; R2是氰基，硝基，卤素，C1-C6-烷基，C1-C6-6烯基，C1-C6-炔基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-烷基羰基或苯基; R3是C1-C4-烷基，C1-C4-烯基或C1-C4-炔基; n为1,2或3，其中在n为2或3的情况下，R 2基团也可以不同，其包括使其中Hal为卤素且X和R 1的式II化合物与 在碱存在下和选自以下组中的钯催化剂存在下：a）钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态，b）钯在三芳基膦或三烷基膦存在下的盐 作为络合配体或c）金属钯，任选地在三芳基膦或三烷基膦存在下，在溶剂中与二苯基硼酸（III）反应，其中R 2和n如上所定义，其中使用三芳基膦或三烷基膦 可以被替代。

公开(公告)号：US07709684B2

公开(公告)日：2010-05-04

申请号：US12087345

申请日：2007-05-31

申请人： Sebastian Peer Smidt ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

发明人： Sebastian Peer Smidt ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

IPC分类号： C07C211/45 ,  C07C211/48 ,  C07C205/06

CPC分类号： C07C201/12 ,  C07C209/68 ,  C07C211/52 ,  C07C205/12

摘要： A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of: a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.

摘要翻译： 制备式I取代的联苯的方法，其中取代基定义如下：X是氟或氯; R1是硝基，氨基或NHR3; R2是氰基，硝基，卤素，C1-C6-烷基，C1-C6-烯基，C1-C6-炔基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-烷基羰基或苯基; R3是C1-C4-烷基，C1-C4-烯基或C1-C4-炔基; n为1,2或3，其中在n为2或3的情况下，R2基团也可以不同，其包括使Hal为卤素的化合物与X和R 1如上所定义的化合物反应在 存在碱和钯催化剂，其选自：a）钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态，b）钯在三芳基膦或三烷基膦作为络合配体存在下的盐，或 c）金属钯，任选地在三芳基膦或三烷基膦存在下，在溶剂中与其中R 2和n如上定义的二苯基硼酸（III）反应，其中所用的三芳基膦或三烷基膦可以被取代。

公开(公告)号：US20100184994A1

公开(公告)日：2010-07-22

申请号：US12664448

申请日：2008-06-13

申请人： Markus Nett ,  Thomas Grote ,  Jan Klaas Lohmann ,  Jochen Dietz ,  Sebastian Peer Smidt ,  Michael Rack ,  Thomas Zierke

发明人： Markus Nett ,  Thomas Grote ,  Jan Klaas Lohmann ,  Jochen Dietz ,  Sebastian Peer Smidt ,  Michael Rack ,  Thomas Zierke

IPC分类号： C07D231/14 ,  C07C229/06

CPC分类号： C07D231/12 ,  C07D231/14

摘要： The present invention relates to a process for preparing 3-difluoromethyl-substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.

摘要翻译： 本发明涉及制备式（I）的3-二氟甲基取代的吡唑化合物的方法，其中R 1是H，卤素，硝基，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基， 苯基，萘基，杂芳基，氰基，-C（= O）-OR1a，-C（= O）-NR1bR1c，-C（= O）-SR1d或-C（= S）-SR1e; R2是H，C1-C4-烷基，苄基或苯基; R 3是H，卤素，C 1 -C 8 - 烷氧基，C 1 -C 8 - 卤代烷氧基，C 3 -C 8 - 环烷氧基，C 2 -C 8 - 烯氧基，C 1 -C 8 - 烷硫基，C 1 -C 8 - 卤代烷硫基，C 3 -C 8环 - C 2 -C 8 - 烯硫基; 式（II.a）或（II.b）化合物，其中R 1和R 3各自具有上述定义之一; R4是卤素，-OR4a，-SR4a，-O-SO2-R4a或-NR4bR4c基团; R 5和R 6各自为C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基，苄基或苯基，或与它们所键合的氮原子一起为3-至8-元杂环; 式（II.b）化合物的路易斯酸加合物; 使用式（II.a）或（II.b）化合物和路易斯酸加成物制备式（I）或（VI）化合物的方法; 以及将这些化合物转化为相应的3-二氟 - 吡唑-4-基羧酸的方法。

公开(公告)号：US08188295B2

公开(公告)日：2012-05-29

申请号：US12664448

申请日：2008-06-13

申请人： Markus Nett ,  Thomas Grote ,  Jan Klaas Lohmann ,  Jochen Dietz ,  Sebastian Peer Smidt ,  Michael Rack ,  Thomas Zierke

发明人： Markus Nett ,  Thomas Grote ,  Jan Klaas Lohmann ,  Jochen Dietz ,  Sebastian Peer Smidt ,  Michael Rack ,  Thomas Zierke

IPC分类号： C07D231/14 ,  C07C229/06

CPC分类号： C07D231/12 ,  C07D231/14

摘要： The present invention relates to a process for preparing 3-difluoromethyl-Substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.

摘要翻译： 本发明涉及一种制备式（I）的3-二氟甲基取代的吡唑化合物的方法，其中R 1是H，卤素，硝基，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基， 苯基，萘基，杂芳基，氰基，-C（= O）-OR1a，-C（= O）-NR1bR1c，-C（= O）-SR1d或-C（= S）-SR1e; R2是H，C1-C4-烷基，苄基或苯基; R 3是H，卤素，C 1 -C 8 - 烷氧基，C 1 -C 8 - 卤代烷氧基，C 3 -C 8 - 环烷氧基，C 2 -C 8 - 烯氧基，C 1 -C 8 - 烷硫基，C 1 -C 8 - 卤代烷硫基，C 3 -C 8环 - C 2 -C 8 - 烯硫基; 式（II.a）或（II.b）化合物，其中R 1和R 3各自具有上述定义之一; R4是卤素，-OR4a，-SR4a，-O-SO2-R4a或-NR4bR4c基团; R 5和R 6各自为C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基，苄基或苯基，或与它们所键合的氮原子一起为3-至8-元杂环; 式（II.b）化合物的路易斯酸加合物; 使用式（II.a）或（II.b）化合物和路易斯酸加成物制备式（I）或（VI）化合物的方法; 以及将这些化合物转化为相应的3-二氟 - 吡唑-4-基羧酸的方法。

公开(公告)号：US20120289706A1

公开(公告)日：2012-11-15

申请号：US13515064

申请日：2010-12-13

申请人： Jens Renner ,  Jochen Dietz ,  Thomas Grote ,  Joachim Gebhardt ,  Markus Nett ,  Michael Keil

发明人： Jens Renner ,  Jochen Dietz ,  Thomas Grote ,  Joachim Gebhardt ,  Markus Nett ,  Michael Keil

IPC分类号： C07D405/06 ,  C07D303/36

CPC分类号： C07D249/12

摘要： The present invention relates to a new process for the preparation of substituted thiotriazolo groups of the general formula (I) wherein the variables have the meanings as given in the claims and the description.

摘要翻译： 本发明涉及制备通式（I）的取代的三优唑基的新方法，其中变量具有权利要求书和说明书中给出的含义。

公开(公告)号：US09295259B2

公开(公告)日：2016-03-29

申请号：US14237041

申请日：2012-08-14

申请人： Jochen Dietz ,  Richard Riggs ,  Nadege Boudet ,  Jan Klaas Lohmann ,  Ian Robert Craig ,  Egon Haden ,  Erica May Wilson Lauterwasser ,  Bernd Mueller ,  Wassilios Grammenos ,  Thomas Grote

发明人： Jochen Dietz ,  Richard Riggs ,  Nadege Boudet ,  Jan Klaas Lohmann ,  Ian Robert Craig ,  Egon Haden ,  Erica May Wilson Lauterwasser ,  Bernd Mueller ,  Wassilios Grammenos ,  Thomas Grote

IPC分类号： A01N43/653 ,  C07D249/08

CPC分类号： A01N43/653 ,  C07D249/08

摘要： The present invention relates to substituted 1-{2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-2-alkoxy-3-methyl-butyl}-1H-[1,2,4]triazole compounds of formula I as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound.

摘要翻译： 本发明涉及取代的1- {2- [2-卤代-4-（4-卤代 - 苯氧基） - 苯基] -2-烷氧基-3-甲基 - 丁基} -1H- [1,2,4]三唑 描述中定义的式I化合物及其N-氧化物及其盐，制备这些化合物的方法和中间体以及包含至少一种这样的化合物的组合物。 本发明还涉及这种化合物和组合物用于防治有害真菌和用至少一种这样的化合物包衣的种子的用途。