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    Carvedilol phosphate sesquihydrate
    2.
    发明授权
    Carvedilol phosphate sesquihydrate 有权
    卡维地洛磷酸倍半水合物

    公开(公告)号：US08344159B2

    公开(公告)日：2013-01-01

    申请号：US12304645

    申请日：2007-06-11

    申请人： Seeta Ramanjaneyulu Gorantla ,  Mohan Bandari ,  Nageshwara Rao Karusala ,  Sankara Sastry Tummalapalli Uma

    发明人： Seeta Ramanjaneyulu Gorantla ,  Mohan Bandari ,  Nageshwara Rao Karusala ,  Sankara Sastry Tummalapalli Uma

    IPC分类号： C07D209/88

    CPC分类号： C07D209/88

    摘要： The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric acid to a suspension of Carvedilol in water, water miscible solvents or a mixture of water and water miscible organic solvent followed by isolating the product directly or by adding solvent.

    摘要翻译： 本发明涉及一种新的1-（恶唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] -2-丙醇磷酸倍半水合物（卡维地洛二氢磷酸倍半水合物）的结晶，通过加入制备倍半水合物的方法 磷酸与卡维地洛在水中的混悬液，水溶性溶剂或水与水混溶的有机溶剂的混合物，然后直接或通过加入溶剂分离产物。

    CARVEDILOL PHOSPHATE SESQUIHYDRATE
    4.
    发明申请
    CARVEDILOL PHOSPHATE SESQUIHYDRATE 有权
    CARVEDILOL磷酸盐水溶液

    公开(公告)号：US20090259051A1

    公开(公告)日：2009-10-15

    申请号：US12304645

    申请日：2007-06-11

    申请人： Seeta Ramanjaneyulu Gorantla ,  Mohan Bandari ,  Nageswara Rao Karusala ,  Sankara Sastry Tummalapalli

    发明人： Seeta Ramanjaneyulu Gorantla ,  Mohan Bandari ,  Nageswara Rao Karusala ,  Sankara Sastry Tummalapalli

    IPC分类号： C07D209/82 ,  A61P9/12

    CPC分类号： C07D209/88

    摘要： The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric acid to a suspension of Carvedilol in water, water miscible solvents or a mixture of water and water miscible organic solvent followed by isolating the product directly or by adding solvent.

    摘要翻译： 本发明涉及一种新的1-（恶唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] -2-丙醇磷酸倍半水合物（卡维地洛二氢磷酸倍半水合物）的结晶，通过加入制备倍半水合物的方法 磷酸与卡维地洛在水中的混悬液，水溶性溶剂或水与水混溶的有机溶剂的混合物，然后直接或通过加入溶剂分离产物。

    Process for the Large Scale Production of Rizatriptan Benzoate
    7.
    发明申请
    Process for the Large Scale Production of Rizatriptan Benzoate 审中-公开
    大量生产利萨曲曲苯甲酸酯的工艺

    公开(公告)号：US20090062550A1

    公开(公告)日：2009-03-05

    申请号：US12093683

    申请日：2006-11-14

    申请人： Purna Chandra Ray ,  Mohan Bandari ,  Mohammed Qadeeruddin ,  Seeta Ramanjaneyulu Gorantla

    发明人： Purna Chandra Ray ,  Mohan Bandari ,  Mohammed Qadeeruddin ,  Seeta Ramanjaneyulu Gorantla

    IPC分类号： C07D249/08

    CPC分类号： C07D403/06

    摘要： The present invention provides a method for preparing pure Rizatriptan benzoate having purity more than 99.5% and dimer impurity less than 0.1% comprises, i) Condensation of 1,2,4-Triazole with 4-Nitro benzyl bromide to yield 1-(4-nitrophenyl)methyl-1,2,4-triazole ii) Reducing the 1-(4-nitrophenyl)methyl-1,2,4-triazole to give 1-(4-aminophenyl)methyl-1,2,4-triazole iii) Converting 1-(4-aminophenyl)methyl-1,2,4-triazole to 1-(4-hydrazinophenyl)methyl-1,2,4-triazole hydrochloride iv) Condensing the hydrazine derivative with 4-(Dimethylamino) butanal diethylacetal to get Rizatriptan and v) Salification of Rizatriptan to Rizatriptan benzoate.

    摘要翻译： 本发明提供一种制备纯度大于99.5％，二聚体杂质小于0.1％的纯粹利扎曲普坦苯甲酸酯的方法，包括：i）1,2,4-三唑与4-硝基苄基溴的缩合，得到1-（4- 硝基苯基）甲基-1,2,4-三唑ii）还原1-（4-硝基苯基）甲基-1,2,4-三唑，得到1-（4-氨基苯基）甲基-1,2,4-三唑iii ）将1-（4-氨基苯基）甲基-1,2,4-三唑转化为1-（4-肼基苯基）甲基-1,2,4-三唑盐酸盐iv）将肼衍生物与4-（二甲基氨基）丁醛二乙缩醛缩合 获得利扎曲坦和v）利扎曲坦对盐酸利扎曲坦的盐化。