公开(公告)号：US20110084019A1

公开(公告)日：2011-04-14

申请号：US12934712

申请日：2009-03-26

申请人： Seimei Shiratori ,  Oriha Kuwaki ,  Jin-Ho Kim ,  Kohei Fukaya ,  Tsuyoshi Mihayashi

发明人： Seimei Shiratori ,  Oriha Kuwaki ,  Jin-Ho Kim ,  Kohei Fukaya ,  Tsuyoshi Mihayashi

IPC分类号： A61L33/00 ,  B32B3/00 ,  B32B33/00 ,  B32B37/24

CPC分类号： A61L33/062 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  Y10T428/24355

摘要： Provided is a surface showing excellent antithrombotic properties. Also provided is a medical device having the same. An antithrombotic surface comprising polymer layers which are in different charged states and alternately layered, characterized by having three-dimensional peaks and valleys formed thereon. The antithrombotic surface as described above which is further characterized in that the peaks and valleys are 15 nm or more but not more than 200 nm in height and depth respectively. A medical device characterized by being provided with the antithrombotic surface as described above. Thus, a thin and highly antithrombotic surface or medical device can be obtained by a relatively convenient method.

摘要翻译： 提供了表现出优异抗血栓性质的表面。 还提供了具有该装置的医疗装置。 一种抗血栓表面，其包含处于不同带电状态并交替层叠的聚合物层，其特征在于其上形成有三维峰和谷。 如上所述的抗血栓表面，其特征还在于，峰和谷的高度和深度分别为15nm以上且不大于200nm。 一种医疗装置，其特征在于具有如上所述的抗血栓表面。 因此，可以通过相对方便的方法获得薄且高抗血栓表面或医疗装置。

公开(公告)号：US20060129229A1

公开(公告)日：2006-06-15

申请号：US10546657

申请日：2004-03-05

申请人： Kohei Fukaya ,  Ryohji Nakano ,  Nobutaka Tani

发明人： Kohei Fukaya ,  Ryohji Nakano ,  Nobutaka Tani

IPC分类号： A61F2/90

CPC分类号： A61F2/915 ,  A61B17/320725 ,  A61B2017/22061 ,  A61F2/91 ,  A61F2002/8483 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155

摘要： A stent that can further reduce the incidence of repeated stenosis (restenosis) that has been experienced in conventional stents is provided. Onto the outer surface of a stent body, a structure for cutting body tissues and the like is disposed so that during stent expansion in the outward radial direction and placement, the body tissues, such as blood vessels, are cut. Thus, the stress and unrestricted damage applied to body tissues such as blood vessels can be reduced, and restenosis can be suppressed. By coating the stent with a drug, a stent having enhanced effects can be provided.

摘要翻译： 提供了可以进一步降低常规支架中经历的重复狭窄（再狭窄）发生率的支架。 在支架体的外表面上，设置有用于切割身体组织等的结构，使得在向外径向的支架扩张和放置时，切割诸如血管的身体组织。 因此，可以减轻施加于身体组织如血管的应力和不受限制的损伤，并且可以抑制再狭窄。 通过用药物涂覆支架，可以提供具有增强效果的支架。

公开(公告)号：US20100041783A1

公开(公告)日：2010-02-18

申请号：US12440712

申请日：2007-09-11

申请人： Masaoki Goto ,  Yoichi Matsumura ,  Shuhei Taniguchi ,  Miaki Shibaya ,  Kohei Fukaya ,  Takaoki Saneyasu ,  Masaki Ichimura

发明人： Masaoki Goto ,  Yoichi Matsumura ,  Shuhei Taniguchi ,  Miaki Shibaya ,  Kohei Fukaya ,  Takaoki Saneyasu ,  Masaki Ichimura

IPC分类号： C08J9/00

CPC分类号： A61L15/425 ,  C08J9/141 ,  C08J2207/10 ,  C08J2383/12 ,  C08J2387/00

摘要： It is intended to provide a resin foam which can be preferably used for medical use, and a flexible silicone type resin foam having a water-absorbing property. The resin foam which has a low toxicity and excellent physical properties for medical use such as moisture permeability, skin compatibility and low irritation can be obtained by using a resin which has a siloxane unit and an oxyalkylene unit in its molecular structure and does not contain a unit derived from an isocyanate group. Further, the flexible silicone type resin foam having a water-absorbing property can be obtained by allowing it to have a specific resin composition and a foam structure.

摘要翻译： 旨在提供一种可优选用于医疗用途的树脂泡沫，以及具有吸水性的柔性硅树脂泡沫。 通过使用在分子结构中具有硅氧烷单元和氧化烯单元的树脂，并且不含有氧化烯的树脂，可以获得具有低毒性和优异物理性能的树脂发泡体，例如透湿性，皮肤相容性和低刺激性 衍生自异氰酸酯基团的单元。 此外，通过使其具有特定的树脂组合物和泡沫结构，可以获得具有吸水性的柔性硅氧烷型树脂发泡体。

公开(公告)号：US20090326640A1

公开(公告)日：2009-12-31

申请号：US12525606

申请日：2008-02-01

申请人： Shinichi Yoshimura ,  Tadaaki Hashimoto ,  Kohei Fukaya

发明人： Shinichi Yoshimura ,  Tadaaki Hashimoto ,  Kohei Fukaya

IPC分类号： A61F2/06 ,  D05B93/00

CPC分类号： A61F2/07 ,  A61B2017/1205 ,  A61B2017/12081 ,  A61F2/90 ,  A61F2/92 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/075

摘要： A medical device for body cavity which has a main stent body and a sheet-shaped member having an opening and covering at least a part of the main stent body as described above. It is desirable that, when the main stent body is dilated from the first diameter in the compressed state to the second diameter, the above-described sheet-shaped member spreads so as to cover at least a part of the main stent body without restricting the movement of the main stent body toward the circumferential direction while the shape of the opening of the above-described sheet-shaped member is retained even after the dilation of the main stent body. The above-described medical device for body cavity is applied to a delivery system which has a first catheter for transporting the medical device for body cavity into the body. In this delivery system, the above-described medical device for body cavity is located at the front end of the first catheter as described above so as to allow indwelling thereof.

摘要翻译： 一种用于体腔的医疗装置，其具有主支架主体和具有开口并覆盖主支架主体的至少一部分的片状构件，如上所述。 理想的是，当主支架主体从压缩状态的第一直径扩张到第二直径时，上述片状构件展开以便覆盖主支架主体的至少一部分而不限制 即使在主支架体扩张之后，主支架主体朝向圆周方向的移动，同时上述片状构件的开口的形状也被保持。 上述用于体腔的医疗装置被应用于具有用于将体腔医疗装置输送到体内的第一导管的输送系统。 在这种传送系统中，上述用于体腔的医疗装置位于第一导管的前端，以便容纳其内置。

公开(公告)号：US06613066B1

公开(公告)日：2003-09-02

申请号：US09787930

申请日：2001-04-03

申请人： Kohei Fukaya ,  Hiromi Maeda ,  Takuji Nishide ,  Shogo Miki ,  Ryoji Nakano ,  Masato Hashiba

发明人： Kohei Fukaya ,  Hiromi Maeda ,  Takuji Nishide ,  Shogo Miki ,  Ryoji Nakano ,  Masato Hashiba

IPC分类号： A61M2900

CPC分类号： A61M25/1029 ,  A61M25/0043 ,  A61M25/0052 ,  A61M25/1034 ,  A61M2025/0004 ,  A61M2025/006 ,  A61M2025/1056 ,  A61M2025/1068 ,  A61M2025/1088 ,  A61M2029/025

摘要： A balloon catheter 1 is configured so as to comprise a catheter shaft 2 formed by joining a proximal-side tubular member 3 and a distal-side tubular member 4, an adapter member 6 connected to the base end of the catheter shaft 2, and a balloon 5 joined to the distal end of the catheter shaft 2. A metal coiled elastic member 10 is deployed in the internal space in the adapter member 6, so that it can move toward the distal end. This coiled elastic body 10 abuts on a ring-shaped wall part 11a formed on the outer circumferential surface of the base end of an elastic force transmitting member 11 and supports the elastic force transmitting member 11 to the distal side. The leading end of a linear member 12 that is one of the components of the elastic force transmitting member 11 reaches to an internal space 5f in the balloon and is bonded to the outer circumferential surface of a guide wire passing tube 7. Thus the elastic supporting force of the coiled elastic body 10 is transmitted via the elastic force transmitting member 11 to the distal-side sleeve part 5d of the balloon 5, and tension is imparted to the balloon 5 in the axial direction.

摘要翻译： 球囊导管1被构造成包括通过连接近侧管状构件3和远端侧管状构件4形成的导管轴2，连接到导管轴2的基端的适配构件6和 气囊5连接到导管轴2的远端。金属螺旋弹性构件10展开在适配构件6的内部空间中，使得其可以朝向远端移动。 该螺旋弹性体10与形成在弹性力传递构件11的基端的外周面上的环状壁部11a抵接，并且将弹力传递构件11支撑在远侧。 作为弹力传递部件11的一个部件的直线部件12的前端到达球囊内的内部空间5f，并且与导丝管7的外周面接合。因此，弹性支撑 螺旋弹性体10的力经由弹力传递部件11传递到球囊5的前侧侧套筒部5d，并且沿轴向向球囊5施加张力。

公开(公告)号：US20060057183A1

公开(公告)日：2006-03-16

申请号：US10542522

申请日：2003-12-19

申请人： Ryohji Nakano ,  Kohei Fukaya ,  Hironori Takata ,  Shinya Yoshida

发明人： Ryohji Nakano ,  Kohei Fukaya ,  Hironori Takata ,  Shinya Yoshida

IPC分类号： A61F2/00

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/608

摘要： As a therapy for angiostenosis, angioplasty (PTA, PTCA), in which a small balloon is inflated in a blood vessel to expand the vessel, has been widely practiced as a minimally invasive treatment. In this therapy, however, repeated stenosis (restenosis) occurs at a high incidence. In order to reduce the restenosis rate, procedures that use indwelling stents have gained popularity in recent years. However, restenosis has been reported in about 20% to 30% of stent placement cases. Although attempts have been made to coat the stent with a drug that regulates occlusion, stenosis still occurs at a high frequency. At least two layers including an immunosuppressant-containing layer and an antiinflammatory agent-containing layer are provided on the surface of an indwelling stent.

摘要翻译： 作为血管狭窄症的治疗方法，血管成形术（PTA，PTCA）已被广泛地用作微创治疗，其中小血管在血管中膨胀以扩张血管。 然而，在这种治疗中，重复狭窄（再狭窄）发生率高。 为了减少再狭窄率，近年来使用留置支架的手术越来越受欢迎。 然而，报告称支架置入病例约占20％〜30％。 尽管已经尝试用调节闭塞的药物涂覆支架，但狭窄仍然以高频发生。 在留置支架的表面上设置包含含有免疫抑制剂的层和含有抗炎剂的层的至少两层。

公开(公告)号：US20120215153A1

公开(公告)日：2012-08-23

申请号：US13503234

申请日：2010-10-22

申请人： Kohei Fukaya ,  Ryoji Nakano ,  Hidekazu Miyauchi

发明人： Kohei Fukaya ,  Ryoji Nakano ,  Hidekazu Miyauchi

IPC分类号： A61F9/00

CPC分类号： A61F9/00772

摘要： A tube device for insertion into a lacrimal passage, optimized according to the structure of a lacrimal passage and capable of being operated without impairing the functional effect of a lacrimal passage endoscope. A tube device for insertion into a lacrimal passage comprises a pair of tubes to be placed in the lacrimal passage. Openings are formed at both ends of the pair of tubes. A reinforcement body is disposed and held in the vicinity of each opening at a position located at a predetermined distance from the opening.

摘要翻译： 用于插入泪道的管装置，根据泪道的结构进行优化，能够在不损伤泪道内窥镜的功能效果的情况下进行操作。 用于插入泪道的管装置包括一对待放置在泪道中的管。 开口形成在一对管的两端。 加强体被设置并保持在位于距开口预定距离的位置处的每个开口附近。

公开(公告)号：US20090076484A1

公开(公告)日：2009-03-19

申请号：US11577794

申请日：2005-10-19

申请人： Kohei Fukaya

发明人： Kohei Fukaya

IPC分类号： A61M25/09 ,  A61M25/098

CPC分类号： A61M25/0068 ,  A61M25/003 ,  A61M25/0043 ,  A61M25/008 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/1056

摘要： The therapeutic catheter comprises a lumen communicating from the user's side end to the terminal tip part thereof, a main shaft having, at its tip, a guide wire lumen, a hub at its user's side end, and a slit in the guide wire lumen through its entire length, or the therapeutic catheter comprises a main shaft having a lumen communicating from the user's side end to the terminal tip part thereof, a guide wire shaft having, at its tip, a guide wire lumen, a hub at the user's side end of the main shaft, and a slit in the guide wire shaft through its entire length. The guide wire or the shaft of the other catheter playing the role of the guide wire can be rapidly disposed in the guide wire lumen through the slit.

摘要翻译： 治疗导管包括从使用者的侧端与其末端部分连通的内腔，主轴在其尖端处具有导丝管腔，在其使用者侧端部处的轮毂和在导丝管腔中的狭缝 其整个长度或治疗导管包括主轴，其具有从使用者的侧端连接到其末端部分的内腔;导丝轴，其尖端处具有导丝管腔，在使用者侧端部具有轮毂 的主轴，以及导丝线轴的整个长度上的狭缝。 作为引导线的作用的另一导管的引导线或轴可以通过狭缝快速地设置在导丝管腔中。

公开(公告)号：US07247147B2

公开(公告)日：2007-07-24

申请号：US10415997

申请日：2001-11-08

申请人： Takuji Nishide ,  Kohei Fukaya ,  Masato Hashiba

发明人： Takuji Nishide ,  Kohei Fukaya ,  Masato Hashiba

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61M25/0045 ,  A61M25/0054

摘要： The medical balloon catheter of the present invention comprises a catheter shaft composed of a distal end shaft and a proximal end shaft and a balloon on the distal end of the distal end shaft, wherein the proximal end shaft is composed of a single member and the distal end portion of the proximal end shaft is lower in rigidity than the other parts thereof. The present invention also provides a medical balloon catheter having a structure in which a tube for passing a guidewire inside thereof is arranged so as to pass inside the balloon and the balloon and tube are fused together in the vicinity of the distal end of the catheter, wherein the ratio of the outer diameter of the small-diameter portion on the distal end side of the tube to the outer diameter of the proximal end portion is no less than 0.85.

摘要翻译： 本发明的医用气囊导管包括由前端轴和近端轴构成的导管轴和远端轴的远端上的气囊，其中，近端轴由单个构件和远端构成 近端轴的端部刚性低于其他部分。 本发明还提供一种医疗气囊导管，其具有将导线内部通过的管布置成在气囊内部通过的结构，并且气球和管在导管的远端附近熔合在一起， 其中，所述管的前端侧的小直径部的外径与所述基端部的外径之比为0.85以上。

公开(公告)号：US20120109058A1

公开(公告)日：2012-05-03

申请号：US13382893

申请日：2010-07-06

申请人： Kohei Fukaya

发明人： Kohei Fukaya

IPC分类号： A61M29/02

CPC分类号： A61F9/00772 ,  A61M25/02 ,  A61M25/09 ,  A61M2025/0293

摘要： Medical devices that are inserted into a body and that are used for treating a lumen inside a body sometimes use an insertion aid during insertion. However, there was a tendency for the relative positions of the insertion aid and the medical device to change, causing problems such as reduced operability and the insertion aid breaking the medical device during insertion. Disclosed are an insertion aid used by being placed within a medical device, and a medical device using said insertion aid. The insertion aid has a mechanism for holding said medical device from the inside, and said medical device uses said insertion aid, thereby making it possible to fix the relative positions of the insertion aid and the medical device when necessary.

摘要翻译： 插入体内并用于治疗体内腔的医疗装置有时在插入时使用插入辅助装置。 然而，插入辅助装置和医疗装置的相对位置存在变化的趋势，导致插入时使操作性降低和插入辅助装置破坏医疗装置等问题。 公开了通过放置在医疗装置内的插入辅助装置和使用所述插入辅助装置的医疗装置。 插入辅助装置具有用于从内部保持医疗装置的机构，并且所述医疗装置使用所述插入辅助装置，从而可以在需要时固定插入辅助装置和医疗装置的相对位置。