公开(公告)号：US4132726A

公开(公告)日：1979-01-02

申请号：US642800

申请日：1975-12-22

申请人： Seizi Kurozumi ,  Takeshi Toru ,  Toshio Tanaka ,  Shuzi Miura ,  Makiko Kobayashi ,  Sachio Ishimoto ,  Sadakazu Matsubara

发明人： Seizi Kurozumi ,  Takeshi Toru ,  Toshio Tanaka ,  Shuzi Miura ,  Makiko Kobayashi ,  Sachio Ishimoto ,  Sadakazu Matsubara

IPC分类号： C07C35/06 ,  C07C45/67 ,  C07D309/12 ,  C07F7/18 ,  C12P7/38 ,  C12P41/00

CPC分类号： C07C49/707 ,  C07C35/06 ,  C07C45/676 ,  C07D309/12 ,  C07F7/1804 ,  C07F7/1856 ,  C12P41/004 ,  C12P7/38 ,  Y02P20/55

摘要： Novel optically active compounds of 4-protected hydroxy-cyclopent-2-en-1-ones of the formula ##STR1## wherein R is a splittable protective group for an alcoholic hydroxyl group, and a process for preparing the 4-protected hydroxycyclopent-2-en-1-ones by oxidizing monohydroxy-protected derivatives of cyclopent-1-ene-3,5-diol expressed by the following formula ##STR2## wherein R is the same as defined above. Optically active 4-hydroxycyclopent-2-en-1-one which is an optically active isomer of the compound of formula (2); or optically active cyclopent-1-en-3,5-diol (R-isomer) and a novel diacyl derivative of the diol, a novel monoacylmonosilyl-derivative of the diol and a novel monoacylmonotetrahydropyranol-derivative of the diol, which are intermediates for the protective derivative of formula (1). Processes are also provided for preparing the protective derivatives of formula (1) by converting these intermediates by esterification, hydrolysis, enzymatic processes, etc. The optically active compounds of formula (2) are useful as precursors for the preparation of prostaglandin or its analogues.

摘要翻译： 新型的具有式（2）的4-保护的羟基 - 环戊-2-烯-1-酮的光学活性化合物，其中R是醇羟基的可裂解的保护基，以及制备4-保护的 羟基环戊-2-烯-1-酮通过氧化由下式（1）表示的环戊-1-烯-3,5-二醇的单羟基保护衍生物，其中R与上述定义相同。 光学活性的4-羟基环戊-2-烯-1-酮，它是式（2）化合物的旋光异构体; 或光学活性的环戊-1-烯-3,5-二醇（R-异构体）和二醇的新型二酰基衍生物，二醇的新型单酰基单甲硅烷基衍生物和二醇的新型单酰基单四氢吡喃醇衍生物，其为 式（1）的保护性衍生物。 还提供了通过酯化，水解，酶法等转化这些中间体来制备式（1）的保护性衍生物的方法。式（2）的光学活性化合物可用作制备前列腺素或其类似物的前体。

公开(公告)号：US4008125A

公开(公告)日：1977-02-15

申请号：US630711

申请日：1975-11-10

申请人： Seizi Kurozumi ,  Takeshi Toru ,  Toshio Tanaka ,  Shuzi Miura ,  Makiko Kobayashi ,  Sadakazu Matsubara ,  Sachio Ishimoto

发明人： Seizi Kurozumi ,  Takeshi Toru ,  Toshio Tanaka ,  Shuzi Miura ,  Makiko Kobayashi ,  Sadakazu Matsubara ,  Sachio Ishimoto

IPC分类号： C07C35/06 ,  C07C45/67 ,  C07D309/12 ,  C07F7/18 ,  C12N9/18 ,  C12P7/38 ,  C12P41/00 ,  C12D13/02

CPC分类号： C12P41/004 ,  C07C35/06 ,  C07C45/67 ,  C07D309/12 ,  C07F7/1856 ,  C12N9/18 ,  C12P7/38 ,  Y10S435/917 ,  Y10S435/942

摘要： New optically active cyclopentene-diol and the mono- or diacyl esters thereof and a process for converting a diacyl ester of cyclopent-1-en-3,5-diol to its monoacyl ester and/or its diol which comprises subjecting a diacyl ester of cyclopent-1-en-3,5-diol containing at least one of the optically active or inactive diacyl ester of trans-cyclopent-1-en-3,5-diol (trans-isomer) and diacyl esters of cis-cyclopent-1-en-3,5-diol (cis-isomer), to the action of a microorganism or enzyme having at least a selectivity in its rates of hydrolyzing the acyloxy group (R) configuration and the acyloxy group (S) configuration of said diacyl ester. These new compounds are valuable as starting materials for the preparation of prostaglandin or its analogues.

摘要翻译： 新的光学活性环戊烯二醇及其单 - 或二酰基酯，以及将环戊-1-烯-3,5-二醇的二酰基酯转化成其单酰基酯和/或其二醇的方法，其包括使二 含有反式环戊-1-烯-3,5-二醇（反式异构体）的光学活性或无活性二酰基酯和顺式环戊烯-1-烯-3,5-二醇的二酰基酯的环戊-1-烯-3,5-二醇， 1-顺-3,5-二醇（顺式异构体）对于水解所述酰氧基（R）构型和所述酰氧基（R）构型的酰氧基（S）构型）的速率至少具有选择性的微生物或酶的作用 二酰基酯。

公开(公告)号：US07682428B2

公开(公告)日：2010-03-23

申请号：US10569463

申请日：2004-08-26

申请人： Hideo Nawata ,  Naotoshi Fujimoto ,  Kanji Kurome ,  Sadakazu Matsubara

发明人： Hideo Nawata ,  Naotoshi Fujimoto ,  Kanji Kurome ,  Sadakazu Matsubara

IPC分类号： B01D53/02

CPC分类号： A61M16/10 ,  A61M16/0677 ,  A61M16/085 ,  A61M16/101 ,  A61M16/107 ,  A61M16/202 ,  A61M16/203 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2016/1025 ,  A61M2202/0208 ,  A61M2202/03 ,  A61M2205/3334 ,  A61M2205/3375 ,  B01D53/0423 ,  B01D53/053 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2259/40005 ,  B01D2259/40007 ,  B01D2259/402 ,  B01D2259/404 ,  B01D2259/4533 ,  G01N29/024 ,  G01N29/326 ,  G01N2291/021 ,  G01N2291/02809 ,  G01N2291/02836 ,  A61M2202/0007

摘要： An oxygen concentration apparatus (300) according to the present invention has: pressure swing adsorption type oxygen concentration means (310); and a control means (350) that controls switching means (316) that switches between intake of pressurized air into an adsorption column (312) and exhaust from the adsorption column. The switching means is controlled based on pressure in oxygen concentrated gas in the conduit measured by pressure measuring means to adjust a cycle of adsorption and regeneration processes of the oxygen concentration means so that pressure at the upstream of flow rate adjusting means (340) can be controlled and, as a result, the need for a mechanical pressure regulating valve, that has been needed conventionally, can be eliminated. Further, there is also shown a gas supply apparatus that comprises ultrasonic type gas concentration and flow rate measuring means that comprises, in turn, two ultrasonic transducers that is disposed in an opposed manner in the conduit through which product gas flows so that a concentration value measured when the product gas output is stopped is determined to be a product gas concentration.

摘要翻译： 本发明的氧浓缩装置（300）具有：变压吸附型氧浓度装置（310）; 以及控制装置（350），其控制将加压空气进入吸附塔（312）并从吸附塔排出的切换装置（316）。 根据由压力测量装置测量的导管中的氧浓缩气体中的压力来控制切换装置，以调节氧浓度装置的吸附和再生过程的循环，使得流量调节装置（340）上游的压力可以是 因此，可以消除对传统上需要的机械压力调节阀的需要。 此外，还示出了包括超声波型气体浓度和流量测量装置的气体供应装置，该装置又包括两个超声换能器，其以相对的方式设置在产品气体流过的导管中，使得浓度值 将产品气体输出停止时测量的气体浓度确定为产物气体浓度。

公开(公告)号：US20070039466A1

公开(公告)日：2007-02-22

申请号：US10569463

申请日：2004-08-26

申请人： Hideo Nawata ,  Natoshi Fujimoto ,  Kanji Kurome ,  Sadakazu Matsubara

发明人： Hideo Nawata ,  Natoshi Fujimoto ,  Kanji Kurome ,  Sadakazu Matsubara

IPC分类号： B01D53/02

CPC分类号： A61M16/10 ,  A61M16/0677 ,  A61M16/085 ,  A61M16/101 ,  A61M16/107 ,  A61M16/202 ,  A61M16/203 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2016/1025 ,  A61M2202/0208 ,  A61M2202/03 ,  A61M2205/3334 ,  A61M2205/3375 ,  B01D53/0423 ,  B01D53/053 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2259/40005 ,  B01D2259/40007 ,  B01D2259/402 ,  B01D2259/404 ,  B01D2259/4533 ,  G01N29/024 ,  G01N29/326 ,  G01N2291/021 ,  G01N2291/02809 ,  G01N2291/02836 ,  A61M2202/0007

摘要： An oxygen concentration apparatus (300) according to the present invention has: pressure swing adsorption type oxygen concentration means (310); and a control means (350) that controls switching means (316) that switches between intake of pressurized air into an adsorption column (312) and exhaust from the adsorption column. The switching means is controlled based on pressure in oxygen concentrated gas in the conduit measured by pressure measuring means to adjust a cycle of adsorption and regeneration processes of the oxygen concentration means so that pressure at the upstream of flow rate adjusting means (340) can be controlled and, as a result, the need for a mechanical pressure regulating valve, that has been needed conventionally, can be eliminated. Further, there is also shown a gas supply apparatus that comprises ultrasonic type gas concentration and flow rate measuring means that comprises, in turn, two ultrasonic transducers that is disposed in an opposed manner in the conduit through which product gas flows so that a concentration value measured when the product gas output is stopped is determined to be a product gas concentration.

摘要翻译： 本发明的氧浓缩装置（300）具有：变压吸附型氧浓度装置（310）; 以及控制装置（350），其控制将加压空气进入吸附塔（312）并从吸附塔排出的切换装置（316）。 根据由压力测量装置测量的导管中的氧浓缩气体中的压力来控制切换装置，以调节氧浓度装置的吸附和再生过程的循环，使得流量调节装置（340）上游的压力可以是 因此，可以消除对传统上需要的机械压力调节阀的需要。 此外，还示出了包括超声波型气体浓度和流量测量装置的气体供应装置，该装置又包括两个超声换能器，其以相对的方式设置在产品气体流过的导管中，使得浓度值 将产品气体输出停止时测量的气体浓度确定为产物气体浓度。

公开(公告)号：US06695956B2

公开(公告)日：2004-02-24

申请号：US10009814

申请日：2001-12-14

申请人： Masato Sugano ,  Sadakazu Matsubara ,  Satoshi Takaichi

发明人： Masato Sugano ,  Sadakazu Matsubara ,  Satoshi Takaichi

IPC分类号： B01D5000

CPC分类号： B01D53/047 ,  A61M16/101 ,  A61M16/107 ,  A61M16/16 ,  A61M16/161 ,  B01D53/0407 ,  B01D53/0446 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2259/40007 ,  B01D2259/402 ,  B01D2259/4533

摘要： An oxygen-concentrating equipment comprising an oxygen-concentrating means for separating oxygen from air and concentrating the oxygen, a humidifying means for humidifying the oxygen-concentrated air produced by said oxygen-concentrating means, and an oxygen-supplying means for supplying the humidified oxygen-concentrated air to a user, characterized in that said humidifying means has at least a cation-conducting solid electrolyte membrane equipped with electrodes on both the sides of the membrane and an electric source for applying an electric current to said electrodes.

摘要翻译： 一种氧浓缩装置，包括用于从氧气分离氧气和浓缩氧气的氧浓缩装置，用于加湿由所述氧浓缩装置产生的氧浓缩空气的加湿装置和用于供应加湿氧气的供氧装置 - 浓缩空气，其特征在于，所述加湿装置至少具有在膜两侧装有电极的阳离子导电固体电解质膜和用于向所述电极施加电流的电源。