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公开(公告)号：US07517964B2
公开(公告)日：2009-04-14
申请号：US11745896
申请日：2007-05-08
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04 , G01N33/574
CPC分类号： A61K45/06 , A61K39/39558 , A61K51/1045 , A61K51/1051 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/21 , C07K2317/24
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。
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公开(公告)号：US20080131363A1
公开(公告)日：2008-06-05
申请号：US11868290
申请日：2007-10-05
IPC分类号： A61K39/395 , A61K38/20 , A61K51/10 , A61P35/04
CPC分类号： C07K16/30 , A61K38/164 , A61K38/168 , A61K38/1816 , A61K38/19 , A61K38/21 , A61K45/06 , A61K47/6805 , A61K47/6857 , A61K51/1054 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/94 , A61K2300/00
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或更多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。
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公开(公告)号：US09745380B2
公开(公告)日：2017-08-29
申请号：US11868290
申请日：2007-10-05
IPC分类号： A61K39/395 , C07K16/30 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/21 , A61K45/06 , A61K47/48 , A61K51/10 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K38/164 , A61K38/168 , A61K38/1816 , A61K38/19 , A61K38/21 , A61K45/06 , A61K47/6805 , A61K47/6857 , A61K51/1054 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/94 , A61K2300/00
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
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公开(公告)号：US07238785B2
公开(公告)日：2007-07-03
申请号：US10377121
申请日：2003-03-03
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04 , G01N33/574
CPC分类号： A61K45/06 , A61K39/39558 , A61K51/1045 , A61K51/1051 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/21 , C07K2317/24
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。
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公开(公告)号：US20070212350A1
公开(公告)日：2007-09-13
申请号：US11745896
申请日：2007-05-08
IPC分类号： A61K39/44 , A61K39/395 , C07K16/30 , C12P21/08
CPC分类号： A61K45/06 , A61K39/39558 , A61K51/1045 , A61K51/1051 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/21 , C07K2317/24
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或更多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。
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公开(公告)号：US20070048227A1
公开(公告)日：2007-03-01
申请号：US11553814
申请日：2006-10-27
申请人： Gary Griffiths , Serengulam Govindan , Hans Hansen
发明人： Gary Griffiths , Serengulam Govindan , Hans Hansen
IPC分类号： A61K39/00
CPC分类号： C07K16/44 , A61K47/665 , A61K47/67 , B82Y5/00 , C07K16/3007 , C07K2317/31 , C07K2317/55
摘要： Embodiments of the invention relate to a method for treating target cells, tissues or pathogens in a subject, comprising administering a non-covalently bound complex which comprises a multispecific targeting protein and a hapten-enzyme covalent conjugate, followed by administration of a prodrug that is converted to an active drug by the enzyme. Other embodiments of the invention further relate to kits comprising the non-covalently bound complex or the components to prepare the complex.
摘要翻译： 本发明的实施方案涉及用于治疗受试者中靶细胞，组织或病原体的方法，包括施用包含多特异性靶向蛋白质和半抗原酶共价缀合物的非共价结合复合物，然后施用前药，其为 通过酶转化为活性药物。 本发明的其它实施方案还涉及包含非共价结合复合物或制备复合物的组分的试剂盒。
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公开(公告)号：US20050191239A1
公开(公告)日：2005-09-01
申请号：US11000500
申请日：2004-12-01
CPC分类号： A61K51/1027 , A61K51/0482 , A61K51/1045
摘要： Improved synthesis methods are provided for preparing conjugates of proteins and chelating agents. In the synthesis methods, non-stable bonds are hydrolyzed after the conjugate is synthesized, for example by treating the conjugate with a quenching agent. The synthesis method provides conjugates that are substantially free of non-stable bonds between the protein and the chelating agent, such that the chelating agent is less likely to dissociate with the conjugate after the conjugate has been stored for extended periods. The conjugate may be useful for therapeutic or diagnostic methods.
摘要翻译： 提供改进的合成方法用于制备蛋白质和螯合剂的缀合物。 在合成方法中，在合成共轭物后，例如通过用猝灭剂处理缀合物，非稳定键被水解。 合成方法提供基本上不含蛋白质和螯合剂之间的非稳定键的缀合物，使得螯合剂在缀合物长时间储存后不太可能与缀合物解离。 缀合物可用于治疗或诊断方法。
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公开(公告)号：US06228362B1
公开(公告)日：2001-05-08
申请号：US09205243
申请日：1998-12-04
IPC分类号： A61K39395
CPC分类号： G01N33/686 , A61K41/0095 , A61K47/665 , A61K47/6893 , A61K47/6897 , A61K47/6898 , A61K51/1078 , A61K51/1093 , A61K2039/505 , A61K2121/00 , A61K2123/00 , B82Y5/00 , C07K16/18 , C07K16/3007 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00 , G01N33/531 , G01N33/534 , G01N33/574
摘要： The present invention provides a method for targeting boron atoms to tumor cells in a patient. The method includes the steps of (A) administering a targeting composition comprising a conjugate of (i) at least one first antibody or antigen-binding antibody fragment which selectively binds to an antigen produced by or associated with the tumor cells and present at the tumor cells, and (ii) at least one second antibody or antibody fragment which specifically binds to a hapten on a boron compound; (B) optionally, a clearing composition; (C) said boron compound; and (D) optionally, a second clearing composition. The method may further comprise the step of irradiating the boron atoms of the boron compound, thereby effecting BNCT of the tumor cells. Compositions and kits for carrying out the method also are provided.
摘要翻译： 本发明提供了一种将硼原子靶向患者肿瘤细胞的方法。 该方法包括以下步骤：（A）施用靶向组合物，所述靶组合物包含（i）至少一种第一抗体或抗原结合抗体片段的缀合物，所述第一抗体或抗原结合抗体片段选择性地结合由肿瘤细胞产生或与肿瘤细胞相关的抗原并且存在于肿瘤 细胞，和（ii）与硼化合物上的半抗原特异性结合的至少一种第二抗体或抗体片段; （B）任选地，清除组合物; （C）所述硼化合物; 和（D）任选地，第二清除组合物。 该方法还可以包括照射硼化合物的硼原子，从而实现肿瘤细胞的BNCT的步骤。 还提供了用于实施该方法的组合物和试剂盒。
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公开(公告)号：US20060193865A1
公开(公告)日：2006-08-31
申请号：US11388032
申请日：2006-03-23
申请人： Serengulam Govindan
发明人： Serengulam Govindan
IPC分类号： C07K16/46 , A61K39/395
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6841 , A61K47/6849 , A61K47/6889 , A61K2039/505 , C07K16/1063 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/76
摘要： The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
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