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    Boron neutron capture therapy using pre-targeting methods
    1.
    发明授权
    Boron neutron capture therapy using pre-targeting methods 失效
    硼中子捕获治疗使用预定位方法

    公开(公告)号：US06228362B1

    公开(公告)日：2001-05-08

    申请号：US09205243

    申请日：1998-12-04

    申请人： Gary L. Griffiths ,  Serengulam Govindan

    发明人： Gary L. Griffiths ,  Serengulam Govindan

    IPC分类号： A61K39395

    CPC分类号： G01N33/686 ,  A61K41/0095 ,  A61K47/665 ,  A61K47/6893 ,  A61K47/6897 ,  A61K47/6898 ,  A61K51/1078 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2121/00 ,  A61K2123/00 ,  B82Y5/00 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00 ,  G01N33/531 ,  G01N33/534 ,  G01N33/574

    摘要： The present invention provides a method for targeting boron atoms to tumor cells in a patient. The method includes the steps of (A) administering a targeting composition comprising a conjugate of (i) at least one first antibody or antigen-binding antibody fragment which selectively binds to an antigen produced by or associated with the tumor cells and present at the tumor cells, and (ii) at least one second antibody or antibody fragment which specifically binds to a hapten on a boron compound; (B) optionally, a clearing composition; (C) said boron compound; and (D) optionally, a second clearing composition. The method may further comprise the step of irradiating the boron atoms of the boron compound, thereby effecting BNCT of the tumor cells. Compositions and kits for carrying out the method also are provided.

    摘要翻译： 本发明提供了一种将硼原子靶向患者肿瘤细胞的方法。 该方法包括以下步骤：（A）施用靶向组合物，所述靶组合物包含（i）至少一种第一抗体或抗原结合抗体片段的缀合物，所述第一抗体或抗原结合抗体片段选择性地结合由肿瘤细胞产生或与肿瘤细胞相关的抗原并且存在于肿瘤 细胞，和（ii）与硼化合物上的半抗原特异性结合的至少一种第二抗体或抗体片段; （B）任选地，清除组合物; （C）所述硼化合物; 和（D）任选地，第二清除组合物。 该方法还可以包括照射硼化合物的硼原子，从而实现肿瘤细胞的BNCT的步骤。 还提供了用于实施该方法的组合物和试剂盒。

    Composite Probes and Use Thereof in Super Resolution Methods
    2.
    发明申请
    Composite Probes and Use Thereof in Super Resolution Methods 有权
    复合探针及其在超分辨率方法中的应用

    公开(公告)号：US20120309045A1

    公开(公告)日：2012-12-06

    申请号：US13519737

    申请日：2010-12-28

    申请人： Jay R. Knutson ,  Gary L. Griffiths

    发明人： Jay R. Knutson ,  Gary L. Griffiths

    IPC分类号： C07K7/06 ,  C12N13/00 ,  B29C59/16 ,  G01N21/21 ,  G01N21/59 ,  G01N21/64 ,  F21V9/16

    CPC分类号： C07K2/00 ,  C09B11/24 ,  C09B23/086 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6432 ,  G01N2021/6441 ,  Y10T436/21

    摘要： Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.

    摘要翻译： 用于通过瞬时激活猝灭剂（STAQ）使用超分辨率的超分辨率光学技术的复合探针包括通过接头连接的供体部分和受体部分，其中受体部分在被入射辐射激发时被激发到例如 ，在受体发射区吸收，使得其激发态的受体部分猝灭供体部分发射的至少一部分。 其他瞬时激活的猝灭机制和部分可以通过减少供体群体来完成相同的任务。 还公开了用于照射包括复合探针的靶材料的选定区域的方法，其中复合探针通过点扩散功能修饰和/或纳米级化学反应提高了分辨率。

    Method for preparing conjugates of proteins and chelating agents
    4.
    发明授权
    Method for preparing conjugates of proteins and chelating agents 有权
    制备蛋白质和螯合剂缀合物的方法

    公开(公告)号：US07259249B2

    公开(公告)日：2007-08-21

    申请号：US11000500

    申请日：2004-12-01

    申请人： Gary L. Griffiths ,  Serengulam V. Govindan

    发明人： Gary L. Griffiths ,  Serengulam V. Govindan

    IPC分类号： C07K1/00

    CPC分类号： A61K51/1027 ,  A61K51/0482 ,  A61K51/1045

    摘要： Improved synthesis methods are provided for preparing conjugates of proteins and chelating agents. In the synthesis methods, non-stable bonds are hydrolyzed after the conjugate is synthesized, for example by treating the conjugate with a quenching agent. The synthesis method provides conjugates that are substantially free of non-stable bonds between the protein and the chelating agent, such that the chelating agent is less likely to dissociate with the conjugate after the conjugate has been stored for extended periods. The conjugate may be useful for therapeutic or diagnostic methods.

    摘要翻译： 提供改进的合成方法用于制备蛋白质和螯合剂的缀合物。 在合成方法中，在合成共轭物后，例如通过用猝灭剂处理缀合物，非稳定键被水解。 合成方法提供基本上不含蛋白质和螯合剂之间的非稳定键的缀合物，使得螯合剂在缀合物长时间储存​​后不太可能与缀合物解离。 缀合物可用于治疗或诊断方法。

    Stable radioiodine conjugates and methods for their synthesis
    8.
    发明授权
    Stable radioiodine conjugates and methods for their synthesis 失效
    稳定的放射性碘共轭物及其合成方法

    公开(公告)号：US06858705B2

    公开(公告)日：2005-02-22

    申请号：US10686436

    申请日：2003-10-16

    申请人： Serengulam V. Govindan ,  Gary L. Griffiths

    发明人： Serengulam V. Govindan ,  Gary L. Griffiths

    IPC分类号： G01N33/534 ,  A61K49/00 ,  A61K51/00 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  C07H3/04 ,  C07K1/107 ,  C07K1/13 ,  G01N33/543 ,  G01N33/60 ,  A61K38/00

    CPC分类号： A61K51/0491 ,  A61K51/088 ,  A61K51/10 ,  A61K51/1093 ,  C07H3/04 ,  C07K1/1077 ,  G01N33/543

    摘要： Methods are described for conjugating radioiodinated non-metabolizable peptides to proteins and antibodies with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising any aminopolycarboxylate-appended peptide, or any carbohydrate-appended peptide, are also provided. Additionally, methods are described for conjugating radioiodinated aminopolycarboxylates to proteins and antibodies, as well as for conjugating radioiodinated non-metabolizable carbohydrates to proteins and antibodies by a variety of chemical approaches. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

    摘要翻译： 描述了将放射性碘化的不可代谢的肽与蛋白质和抗体结合的方法，其具有改进的缀合物的产率和质量。 还提供了包含任何氨基多羧酸盐附着肽或任何碳水化合物附加肽的放射性碘化残留抗体缀合物。 另外，描述了将放射性碘化氨基多羧酸盐与蛋白质和抗体结合的方法，以及通过各种化学方法将放射性碘化的不可代谢的碳水化合物与蛋白质和抗体缀合。 瞬时放射性碘化残留抗体缀合物在体内特别稳定，适用于放射免疫检测和放射免疫治疗。

    Site-specific labeling of disulfide-containing targeting vectors
    9.
    发明授权
    Site-specific labeling of disulfide-containing targeting vectors 有权
    二硫化物靶向载体的位点特异性标记

    公开(公告)号：US06576746B2

    公开(公告)日：2003-06-10

    申请号：US09417109

    申请日：1999-10-13

    申请人： William J. McBride ,  Gary L. Griffiths

    发明人： William J. McBride ,  Gary L. Griffiths

    IPC分类号： C07K1600

    CPC分类号： G01N33/531 ,  A61K47/6889 ,  A61K51/1093 ,  Y10S435/81

    摘要： A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and bearing at least one thiol-containing moiety linked thereto through a hydrazone or hydrazine linkage, is effected by contacting said protein, polypeptide or peptide with a thiol-reactive diagnostic or therapeutic agent, either preformed or generated in situ, to form a stable diagnostic or therapeutic conjugate of the protein, polypeptide or peptide without substantial cleavage of the disulfide bond. Diagnostic and therapeutic conjugates produced using the foregoing method, as well as kits for carrying out the method are provided.

    摘要翻译： 产生含有维持其生物学活性所必需的至少一个二硫键的蛋白质，多肽或肽的诊断或治疗性缀合物的方法，以及通过腙或肼键连接至少一个含硫醇的部分， 通过将所述蛋白质，多肽或肽与硫醇反应性诊断或治疗剂接触，其通过预先形成或原位产生，以形成蛋白质，多肽或肽的稳定的诊断或治疗缀合物，而不显着切割二硫键。 提供了使用上述方法制备的诊断和治疗缀合物，以及用于实施该方法的试剂盒。