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公开(公告)号:US07410982B2
公开(公告)日:2008-08-12
申请号:US10532765
申请日:2003-10-24
申请人: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann (nee Fagan) Whatton , Victor Matassa , Chad Nolan Wolfe
发明人: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann (nee Fagan) Whatton , Victor Matassa , Chad Nolan Wolfe
IPC分类号: A61K31/4365 , C07D409/02
CPC分类号: C07D275/04 , C07D215/20 , C07D217/02 , C07D217/04 , C07D217/24 , C07D277/62 , C07D333/54 , C07D471/04 , C07D495/04
摘要: There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl —S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, nitro acetyl, —CF3, —SCF3 and cyano; Z is selected from H, OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof.
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公开(公告)号:US07410996B2
公开(公告)日:2008-08-12
申请号:US10533328
申请日:2003-10-24
申请人: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Victor Giulio Matassa , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann Whatton , Chad Nolan Wolfe
发明人: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Victor Giulio Matassa , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann Whatton , Chad Nolan Wolfe
IPC分类号: A61K31/381 , C07D333/64
CPC分类号: C07D275/04 , C07C217/16 , C07C217/30 , C07C217/48 , C07C323/32 , C07D307/86 , C07D333/54 , C07D333/62 , C07D475/04
摘要: There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, nitro, acetyl, —CF3, —SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof with the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is OR3 and X is optionally substituted phenyl then A is —S—.
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公开(公告)号:US07417064B2
公开(公告)日:2008-08-26
申请号:US10532657
申请日:2003-10-24
申请人: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Victor Giulio Matassa , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann Whatton , Chad Nolan Wolfe
发明人: Serge Louis Boulet , Sandra Ann Filla , Peter Thaddeus Gallagher , Kevin John Hudziak , Anette Margareta Johansson , Rushad E. Karanjawala , John Joseph Masters , Victor Giulio Matassa , Brian Michael Mathes , Richard Edmund Rathmell , Maria Ann Whatton , Chad Nolan Wolfe
IPC分类号: A61K31/381 , C07D333/64
CPC分类号: C07C217/20 , C07C217/34 , C07D333/54
摘要: There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, nitro, acetyl, —CF3, —SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from H, OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; with the proviso that, when Z is H, then Y may not be optionally substituted phenyl or optionally substituted naphthyl.
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4.
公开(公告)号:US07521462B2
公开(公告)日:2009-04-21
申请号:US10597795
申请日:2005-02-11
申请人: Serge Louis Boulet , Barry Peter Clark , John Fairhurst , Peter Thaddeus Gallagher , Anette Margareta Johansson , Maria Ann Whatton , Virginia Ann Wood
发明人: Serge Louis Boulet , Barry Peter Clark , John Fairhurst , Peter Thaddeus Gallagher , Anette Margareta Johansson , Maria Ann Whatton , Virginia Ann Wood
IPC分类号: A61K31/4468 , A61K31/4535
CPC分类号: C07D513/04 , A61K31/454 , A61K31/4545 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要: The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.
摘要翻译: 本发明提供式(I)化合物,其中n,R 1,R 2,R 3,R 4,R 5和杂芳基如本文所定义。 这些化合物是一种或多种选自5-羟色胺,去甲肾上腺素和多巴胺的单胺摄取的抑制剂,因此可用于治疗中枢和/或周围神经系统疾病。
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公开(公告)号:US08173821B2
公开(公告)日:2012-05-08
申请号:US12754800
申请日:2010-04-06
申请人: Nicolas Jacques Francois Dreyfus , Sandra Ann Filla , Anette Margareta Johansson , Thierry J. Masquelin , Jikesh Arvind Shah , Eric George Tromiczak , Magnus Wilhelm Walter
发明人: Nicolas Jacques Francois Dreyfus , Sandra Ann Filla , Anette Margareta Johansson , Thierry J. Masquelin , Jikesh Arvind Shah , Eric George Tromiczak , Magnus Wilhelm Walter
IPC分类号: C07D213/62 , A61K31/44
CPC分类号: C07D401/12 , A61K31/4439
摘要: A serotonin and norepinephrine reuptake inhibitor of the formula: its uses, and methods for its preparation are described.
摘要翻译: 描述了5-羟色胺和去甲肾上腺素再摄取抑制剂,其用途及其制备方法。
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