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    Camptothecin derivatives having antitumor activity
    1.
    发明授权
    Camptothecin derivatives having antitumor activity 有权
    喜树碱衍生物具有抗肿瘤活性

    公开(公告)号：US06589939B2

    公开(公告)日：2003-07-08

    申请号：US09741818

    申请日：2000-12-22

    申请人： Sergio Penco ,  Lucio Merlini ,  Paolo Carminati ,  Franco Zunino

    发明人： Sergio Penco ,  Lucio Merlini ,  Paolo Carminati ,  Franco Zunino

    IPC分类号： A61K3170

    CPC分类号： C07D491/22

    摘要： Camptothecin derivatives of camptothecin of formula (I): wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.

    摘要翻译： 式（I）的喜树碱喜树碱衍生物：其中基团R 1，R 2和R 3如说明书中所定义。式（I）化合物具有抗肿瘤活性并具有良好的治疗指标。制备方法 的式（I）化合物及其在制备用于治疗肿瘤，病毒感染和恶性疟原虫的药物中的用途。

    Camptothecin derivatives having antitumor activity
    2.
    发明授权
    Camptothecin derivatives having antitumor activity 有权
    喜树碱衍生物具有抗肿瘤活性

    公开(公告)号：US06242457B1

    公开(公告)日：2001-06-05

    申请号：US09507928

    申请日：2000-02-22

    申请人： Sergio Penco ,  Lucio Merlini ,  Paolo Carminati ,  Franco Zunino

    发明人： Sergio Penco ,  Lucio Merlini ,  Paolo Carminati ,  Franco Zunino

    IPC分类号： A61K314761

    CPC分类号： C07D491/22

    摘要： Camptothecin derivatives of camptothecin of formula (I) wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.

    摘要翻译： 公开了式（I）的喜树碱喜树碱衍生物，其中基团R 1，R 2和R 3如说明书中所定义。式（I）化合物具有抗肿瘤活性并具有良好的治疗指标。 还公开了式（I）化合物及其在制备用于治疗肿瘤，病毒感染和恶性疟原虫药物中的用途。

    COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT
    3.
    发明申请
    COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT 审中-公开
    一种杀真菌剂和一种白蚁反应剂的组合

    公开(公告)号：US20100330200A1

    公开(公告)日：2010-12-30

    申请号：US12517926

    申请日：2007-12-11

    申请人： Paolo Carminati ,  Claudio Pisano ,  Loredana Vesci ,  Franco Zunino

    发明人： Paolo Carminati ,  Claudio Pisano ,  Loredana Vesci ,  Franco Zunino

    IPC分类号： A61K33/24 ,  A61P35/00 ,  A61P35/04

    CPC分类号： A61K33/24 ,  A61K31/192 ,  A61K31/282 ,  A61K45/06 ,  A61K2300/00

    摘要： A combination comprising an atypical retinoid compound, preferably E-4-(3-(1-adamantyl)-4-hydroxyphenyl)cinnamic acid and an anticancer drug of the platinum family, preferably cisuplatin, together with a pharmaceutical composition comprising it and a kit for its administration in unitary or in coordinated sequential form. The kit preferably comprises a first formulation of E-4-(3-(1-adamantyl)-4-hydroxyphenyl)cinnamic acid dissolved in a mixture of ethanol and cremophor, and susupended in a saline solution, and a second formulation of cisuplatin in saline solution. The combination is used for the preparation of a medicament to inhibit tumor growth and tumor migration, in particular for the treatment of ovarian tumor and/or carcinoma.

    摘要翻译： 包含非典型类视色素化合物，优选E-4-（3-（1-金刚烷基）-4-羟基苯基）肉桂酸和铂族的抗癌药物，优选顺铂，以及包含它的药物组合物和试剂盒 以统一或协调的顺序形式进行管理。 试剂盒优选包含溶解在乙醇和Cremophor的混合物中并在盐溶液中混悬的E-4-（3-（1-金刚烷基）-4-羟基苯基）肉桂酸的第一配方，并且将顺铂的第二制剂 生理盐水。 该组合用于制备抑制肿瘤生长和肿瘤迁移的药物，特别是用于治疗卵巢肿瘤和/或癌。

    Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity
    8.
    发明授权
    Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity 失效
    具有非典型抗精神病活性的吡咯并[2,1-b]苯并硫氮杂的脱烷基衍生物

    公开(公告)号：US07713956B2

    公开(公告)日：2010-05-11

    申请号：US11579806

    申请日：2005-04-28

    申请人： Paolo Carminati ,  Maria Assunta Di Cesare ,  Orlando Ghirardi ,  Patrizia Minetti ,  Maria Ornella Tinti

    发明人： Paolo Carminati ,  Maria Assunta Di Cesare ,  Orlando Ghirardi ,  Patrizia Minetti ,  Maria Ornella Tinti

    IPC分类号： A61P25/18 ,  A61K31/407 ,  C07D513/04

    CPC分类号： C07D513/04

    摘要： Derivatives of pyrrolo[2,1-b]benzothiazepines with formula (I) where A is CH—CH2C═CH; R is hydrogen, halogen, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, C5-C6 cycloalkyl; R1 is 1-peperazinyl, 1-homopiperazinyl and 1-piperidinyl; R2 is hydrogen, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, CHO, CH═NOH,CH2OH. The formula (I) compounds are endowed with characteristic atypical anti-psychotic activity, and are therefore useful as medicaments, in particular for the treatment and prevention of schizophrenia, paranoid states, manic-depressive states, disorders of the affective sphere, social regression, personality regression, and hallucinations. Said compounds also present advantageous pharmacokinetic properties.

    摘要翻译： 吡咯并[2,1-b]苯并硫氮杂与式（I）的衍生物，其中A是CH-CH 2 C = CH; R是氢，卤素，C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基，C 5 -C 6环烷基; R1是1-哌嗪基，1-高哌嗪基和1-哌啶基; R 2是氢，C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基，CHO，CH = NH，CH 2 OH。 式（I）化合物具有特征性非典型抗精神病活性，因此可用作药物，特别是用于治疗和预防精神分裂症，偏执状态，躁狂抑郁状态，情感障碍，社会回归， 人格回归和幻觉。 所述化合物还表现出有利的药代动力学性质。

    Anti-met monoclonal antibody, fragments and derivatives thereof for use in tumor diagnosis, corresponding compositions and kits
    10.
    发明申请
    Anti-met monoclonal antibody, fragments and derivatives thereof for use in tumor diagnosis, corresponding compositions and kits 审中-公开
    用于肿瘤诊断的抗met单克隆抗体，其片段和衍生物，相应的组合物和试剂盒

    公开(公告)号：US20090297439A1

    公开(公告)日：2009-12-03

    申请号：US12155330

    申请日：2008-06-02

    申请人： Paolo Maria Comoglio ,  Paolo Carminati ,  Guus Van Dongen

    发明人： Paolo Maria Comoglio ,  Paolo Carminati ,  Guus Van Dongen

    IPC分类号： A61K51/10 ,  A61K49/04 ,  A61K103/00 ,  A61K103/32 ,  A61K101/02 ,  A61K49/16

    CPC分类号： A61K51/1027 ,  A61K49/16

    摘要： An immuno-imaging agent for the detection of tumor cells by means of an immuno-imaging technique, including at least one of: an anti-Met monoclonal antibody, a fragment of an anti-Met monoclonal antibody containing the epitope binding region thereof, a genetically engineered antibody containing the epitope binding region of an anti-Met monoclonal antibody, a humanized antibody containing the epitope binding region of an anti-Met monoclonal antibody, or combinations thereof, wherein the anti-Met monoclonal antibody is produced by the hybridoma cell line ICLC PD 05006, and corresponding compositions and kits.

    摘要翻译： 一种用于通过免疫成像技术检测肿瘤细胞的免疫显像剂，包括以下中的至少一种：抗Met单克隆抗体，含有其表位结合区的抗-MC单克隆抗体的片段， 含有抗Met单克隆抗体的表位结合区的遗传工程抗体，含有抗Met单克隆抗体的表位结合区的人源化抗体或其组合，其中所述抗Met单克隆抗体是由杂交瘤细胞系 ICLC PD 05006和相应的成分和试剂盒。