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34 条记录 (耗时 0.028 秒)

    TREATMENT FOR COCAINE ADDICTION
    1.
    发明申请
    TREATMENT FOR COCAINE ADDICTION 审中-公开
    加拿大的治疗

    公开(公告)号：US20130165511A1

    公开(公告)日：2013-06-27

    申请号：US13820338

    申请日：2011-08-31

    申请人： Seth Lederman ,  Herbert Harris

    发明人： Seth Lederman ,  Herbert Harris

    IPC分类号： A61K31/137 ,  A61K31/16

    CPC分类号： A61K31/16 ,  A61K31/27 ,  A61K31/275 ,  A61K31/535 ,  A61K45/06 ,  A61K2300/00

    摘要： A novel pharmaceutical composition is provided for the control of stimulant effects, in particular treatment of cocaine addiction, or further to treatment of both cocaine and alcohol dependency, including simultaneous therapeutic dose application or a single dose of a combined therapeutically effective composition of disulfiram and selegiline compounds or pharmaceutically acceptable non-toxic salt thereof.

    摘要翻译： 提供了一种新颖的药物组合物，用于控制兴奋剂效应，特别是治疗可卡因成瘾，或进一步治疗可卡因和酒精依赖性，包括同时治疗剂量施用或单剂量联合治疗有效组合物的双硫仑和司来吉兰 化合物或其药学上可接受的无毒盐。

    Isolated fragments of p62 nucleoporin and uses thereof
    3.
    发明申请
    Isolated fragments of p62 nucleoporin and uses thereof 审中-公开
    p62核蛋白的分离片段及其用途

    公开(公告)号：US20060035823A1

    公开(公告)日：2006-02-16

    申请号：US09930864

    申请日：2001-08-16

    申请人： Seth Lederman ,  Christopher Gamper

    发明人： Seth Lederman ,  Christopher Gamper

    IPC分类号： A61K38/17 ,  C07K14/705

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  C07K14/47

    摘要： The invention is directed to isolated protein fragments of p62 nucleoporin including deletion isoforms and nucleic acid sequences encoding these deletion isoforms. The isolated deletion isoforms disclosed herein include the sequences: SEQ. ID NO.:1 MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF SLATQTPATQ TTGFTFGTAT LASGGTGFSL GIGASKLNLS NTAATPAMAN PSGFGLGSSN LTNAISSTVT SSQGTAPTGF VFGPSTTSVA PATTSGGFSF TGGSTAQPSG FNIGSAGNSA QPTAPATLPF TPATPAATTA GATQPAAPTP TATITSTGPS LFASIATAPT SSATTGLSLC TPVTTAGAPT AGTQGFSLKA PGAASGTSTT TSTAATATAT TTTSSSTTGF ALNLKPLAPA GIPSNTAAAV TAPPGPGAAA GAAASSAMTY AQLESLINKW SLELEDQERH FLQQATQVNA WDRTLIENGE KITSLHREVE KVKLDQKRLD QEL; SEQ ID NO.:2 LINKWSLELE DQERHFLQQA TQVNAWDRTL IENGEKITSL HREVEKVKLD QKRLDQELDF ILSQQKELED LLSPLEELVK EQRATIYLQH ADEERQKTYK LAENIDAQLK RMAQDLKDII EHLNTSGAPA DTSDPLQQIC KILNAHMDSL QWIDQNSALL QRKVEEVTKV CVGRRKEQER SFRITFD. The invention is also directed to peptides which are at least 80% identical over their entire amino acid sequence set forth in SEQ ID NO:1, and SEQ ID NO:2 and salts thereof. Pharmaceutical compositions including the polypeptides, their isoforms, and methods for their use activating target genes are also provided.

    摘要翻译： 本发明涉及分离的p62核蛋白的蛋白质片段，包括缺失同种型和编码这些缺失同种型的核酸序列。 本文公开的分离的缺失同种型包括序列：SEQ ID NO： ID NO.:1 MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF SLATQTPATQ TTGFTFGTAT LASGGTGFSL GIGASKLNLS NTAATPAMAN PSGFGLGSSN LTNAISSTVT SSQGTAPTGF VFGPSTTSVA PATTSGGFSF TGGSTAQPSG FNIGSAGNSA QPTAPATLPF TPATPAATTA GATQPAAPTP TATITSTGPS LFASIATAPT SSATTGLSLC TPVTTAGAPT AGTQGFSLKA PGAASGTSTT TSTAATATAT TTTSSSTTGF ALNLKPLAPA GIPSNTAAAV TAPPGPGAAA GAAASSAMTY AQLESLINKW SLELEDQERH FLQQATQVNA WDRTLIENGE KITSLHREVE KVKLDQKRLD QEL; SEQ ID NO.:2 LINKWSLELE DQERHFLQQA TQVNAWDRTL IENGEKITSL HREVEKVKLD QKRLDQELDF ILSQQKELED LLSPLEELVK EQRATIYLQH ADEERQKTYK LAENIDAQLK RMAQDLKDII EHLNTSGAPA DTSDPLQQIC KILNAHMDSL QWIDQNSALL QRKVEEVTKV CVGRRKEQER SFRITFD。 本发明还涉及在SEQ ID NO：1和SEQ ID NO：2所示的其全部氨基酸序列及其盐上至少80％相同的肽。 还提供了包括多肽，其同工型及其使用激活靶基因的方法的药物组合物。

    Methods and Compositions for Treating Depression using Cyclobenzaprine
    6.
    发明申请
    Methods and Compositions for Treating Depression using Cyclobenzaprine 审中-公开
    使用环苯扎林治疗抑郁症的方法和组合

    公开(公告)号：US20120232159A1

    公开(公告)日：2012-09-13

    申请号：US13412571

    申请日：2012-03-05

    申请人： Seth Lederman

    发明人： Seth Lederman

    IPC分类号： A61K31/137 ,  A61P25/24

    CPC分类号： A61K31/137 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to methods for the treatment or prevention of depression, and related pharmaceutical compositions. Of particular interest are pharmaceutical compositions comprising cyclobenzaprine, alone, or in combination with an antidepressant drug.

    摘要翻译： 本发明涉及治疗或预防抑郁症的方法及相关的药物组合物。 特别令人感兴趣的是包含环苯扎林，单独或与抗抑郁药组合的药物组合物。

    TRAF-3 deletion isoforms and uses thereof
    9.
    发明授权
    TRAF-3 deletion isoforms and uses thereof 失效
    TRAF-3缺失同种型及其用途

    公开(公告)号：US06849415B2

    公开(公告)日：2005-02-01

    申请号：US09950902

    申请日：2001-09-10

    申请人： Seth Lederman ,  Winfried Van Eyndhoven

    发明人： Seth Lederman ,  Winfried Van Eyndhoven

    IPC分类号： A61K38/00 ,  C07K14/715 ,  G01N33/567 ,  C07K14/00 ,  A61B5/055

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  Y02A50/401

    摘要： The present invention provides an isolated TRAF-3 deletion isoform encoded by the nucleic acid sequence (SEQ ID NO:1) shown in FIG. 15 (deletion isoform Δ130 nucleid acid). One embodiment of the present invention is an isolated TRAF-3 protein which comprised the sequence in FIG. 16 (SEQ ID NO: 2) (Δ130 protein).

    摘要翻译： 本发明提供由图1所示的核酸序列（SEQ ID NO：1）编码的分离的TRAF-3缺失同种型。 15（缺失同种型Delta130核酸）。 本发明的一个实施方案是分离的TRAF-3蛋白，其包含图1中的序列。 16（SEQ ID NO：2）（Delta130蛋白）。

    Protein recognized by an antibody that specifically binds an epitope that is specifically bound by monoclonal antibody 5c8.
    10.
    发明授权
    Protein recognized by an antibody that specifically binds an epitope that is specifically bound by monoclonal antibody 5c8. 失效
    通过特异性结合由单克隆抗体5c8特异性结合的表位的抗体识别的蛋白质。

    公开(公告)号：US06793924B2

    公开(公告)日：2004-09-21

    申请号：US10183903

    申请日：2002-06-25

    申请人： Seth Lederman ,  Leonard Chess ,  Michael J. Yellin

    发明人： Seth Lederman ,  Leonard Chess ,  Michael J. Yellin

    IPC分类号： A61K3817

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K47/68 ,  A61K47/6849 ,  A61K51/1039 ,  A61K51/1087 ,  A61K2123/00 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2319/00 ,  C12N5/0694 ,  Y02A50/401 ,  Y10S514/885

    摘要： This invention provides a protein free of cell membranes and other cellular components, said protein being specifically recognized by an antibody that specifically binds an epitope that is specifically bound by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916. This invention further provides a protein that is a fragment of a protein specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916, wherein said fragment is free of cell membranes and other cellular components and comprises an epitope that is specifically bound by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916. This invention also provides a protein free of cell membranes and other cellular components, said protein consisting essentially of an epitope that is specifically bound by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916.

    摘要翻译： 本发明提供了不含细胞膜和其它细胞组分的蛋白质，所述蛋白质由特异性结合由具有ATCC登录号HB 10916的杂交瘤产生的单克隆抗体5c8特异性结合的表位的抗体特异性识别。本发明进一步 提供蛋白质，其是由具有ATCC登录号HB 10916的杂交瘤产生的单克隆抗体5c8特异性识别的蛋白质的片段，其中所述片段不含细胞膜和其它细胞成分，并且包含特异性结合单克隆抗体 抗体5c8由具有ATCC登录号HB 10916的杂交瘤产生。本发明还提供了不含细胞膜和其它细胞成分的蛋白质，所述蛋白质基本上由由具有ATCC的杂交瘤产生的单克隆抗体5c8特异性结合的表位组成 登录号HB 10916。