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公开(公告)号：US09592409B2
公开(公告)日：2017-03-14
申请号：US12707197
申请日：2010-02-17
CPC分类号： A61B5/4836 , A61B5/0042 , A61B5/0476 , A61B5/055 , A61B6/037 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N2007/0021 , A61N2007/0026 , A61N2007/0078
摘要： A method for modifying neuronal activity in a subject with focused ultrasound pulses (“FUP”) is provided. Such a methods is applicable for research, treatment, and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include neuronal circuits in the brain. The application of focused ultrasound pulses is generally via multiple ultrasound transducers that are housed in a cap worn by the subject. The application of FUP at different tone burst duration, total sonication duration, and pulse repetition frequency settings results in either the inducement of either an increase or decrease in neuronal activity.
摘要翻译： 提供了一种用聚焦超声脉冲（“FUP”）修饰受试者神经元活动的方法。 这种方法适用于精神，神经和神经内分泌疾病的研究，治疗和诊断，其生物学机制包括脑中的神经元回路。 聚焦超声波脉冲的应用通常是通过多个超声波换能器来容纳在受试者佩戴的帽中。 FUP在不同色调持续时间，总超声处理持续时间和脉冲重复频率设置中的应用导致神经元活动的增加或减少的诱导。
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公开(公告)号：US07283861B2
公开(公告)日：2007-10-16
申请号：US10135137
申请日：2002-04-30
申请人： Alexander Bystritsky
发明人： Alexander Bystritsky
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B2090/374 , A61N2007/0078
摘要： Disclosed herein are methods for modifying electrical currents in brain circuits through the simultaneous use of focused ultrasound pulse (FUP) and an existing brain-imaging system, such as a functional magnetic resonance imaging (fMRI) system. The methods are used for research, treatment and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include brain circuits. The methods include the simultaneous steps of applying FUP to a live neuronal circuit within a brain and monitoring a brain image produced by a brain imaging system during the application of FUP.
摘要翻译： 本文公开了通过同时使用聚焦超声脉冲（FUP）和现有脑成像系统（诸如功能磁共振成像（fMRI））系统来修改脑电路中的电流的方法。 这些方法用于精神，神经和神经内分泌障碍的研究，治疗和诊断，其生物学机制包括脑电路。 所述方法包括将FUP应用于脑内活体神经元电路并监测在应用FUP期间由脑成像系统产生的脑图像的同步步骤。
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公开(公告)号：US08086296B2
公开(公告)日：2011-12-27
申请号：US11895687
申请日：2007-08-27
申请人： Alexander Bystritsky
发明人： Alexander Bystritsky
IPC分类号： A61B5/055
CPC分类号： A61N7/02 , A61B2090/374 , A61N2007/0078
摘要： Disclosed herein are methods for modifying electrical currents in brain circuits through the simultaneous use of focused ultrasound pulse (FUP) and an existing brain-imaging system, such as a functional magnetic resonance imaging (fMRI) system. The methods are used for research, treatment and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include brain circuits. The methods include the simultaneous steps of applying FUP to a live neuronal circuit within a brain and monitoring a brain image produced by a brain imaging system during the application of FUP.
摘要翻译： 本文公开了通过同时使用聚焦超声脉冲（FUP）和现有脑成像系统（诸如功能磁共振成像（fMRI））系统来修改脑电路中的电流的方法。 这些方法用于精神，神经和神经内分泌障碍的研究，治疗和诊断，其生物学机制包括脑电路。 所述方法包括将FUP应用于脑内活体神经元电路并监测在应用FUP期间由脑成像系统产生的脑图像的同步步骤。
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公开(公告)号：US20070299370A1
公开(公告)日：2007-12-27
申请号：US11895687
申请日：2007-08-27
申请人： Alexander Bystritsky
发明人： Alexander Bystritsky
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B2090/374 , A61N2007/0078
摘要： Disclosed herein are methods for modifying electrical currents in brain circuits through the simultaneous use of focused ultrasound pulse (FUP) and an existing brain-imaging system, such as a functional magnetic resonance imaging (fMRI) system. The methods are used for research, treatment and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include brain circuits. The methods include the simultaneous steps of applying FUP to a live neuronal circuit within a brain and monitoring a brain image produced by a brain imaging system during the application of FUP.
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