公开(公告)号：US08386056B2

公开(公告)日：2013-02-26

申请号：US11070842

申请日：2005-02-24

申请人： Tamir Ben David ,  Shai Ayal ,  Ehud Cohen

发明人： Tamir Ben David ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

摘要翻译： 提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。 还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

公开(公告)号：US08116881B2

公开(公告)日：2012-02-14

申请号：US11978776

申请日：2007-10-29

申请人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

发明人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve, including a housing, configured to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve when the housing is placed in the vicinity of the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing such that the at least one electrode is between the end insulating elements, and the end insulating elements come in contact or practically in contact with the nerve when the housing is placed in the vicinity of the nerve. Other embodiments are also described.

摘要翻译： 提供了用于将电流施加到神经的装置，包括被配置为放置在神经附近的壳体。 至少一个电极被固定到壳体，使得当壳体放置在神经附近时，至少一个电极不会与神经直接物理接触，并且使得电极围绕大于180度的 放置外壳后神经的周长。 两个端部绝缘元件固定到壳体上，使得至少一个电极位于端部绝缘元件之间，并且当壳体放置在神经附近时，端部绝缘元件接触或实际上与神经接触。 还描述了其它实施例。

公开(公告)号：US07904151B2

公开(公告)日：2011-03-08

申请号：US11975407

申请日：2007-10-19

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/39

CPC分类号： A61N1/36114 ,  A61N1/3621

摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

摘要翻译： 提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏 脉冲和抗心律变能。 所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。 第一和第二控制单元不在一般控制之下。 控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。 还描述了其它实施例。

公开(公告)号：US07778711B2

公开(公告)日：2010-08-17

申请号：US10719659

申请日：2003-11-20

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

摘要翻译： 提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。 还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

公开(公告)号：US20100010603A1

公开(公告)日：2010-01-14

申请号：US12217930

申请日：2008-07-09

申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/0556 ,  A61N1/36114

摘要： Apparatus is provided for application to a nerve of a subject, including a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities. Other embodiments are also described.

摘要翻译： 提供了将装置应用于受试者的神经，包括外壳，其构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。 多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔 住房。 一个或多个电极在少于所有的空腔中固定到壳体。 还描述了其它实施例。

公开(公告)号：US20080161895A1

公开(公告)日：2008-07-03

申请号：US11981301

申请日：2007-10-30

申请人： Yossi Gross ,  Shai Ayal ,  Ehud Cohen

发明人： Yossi Gross ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.

公开(公告)号：US20080140141A1

公开(公告)日：2008-06-12

申请号：US11975654

申请日：2007-10-19

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen ,  Shai Ayal

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen ,  Shai Ayal

IPC分类号： A61N1/36

CPC分类号： A61N1/36114

摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间 ，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。 还描述了其它实施例。

公开(公告)号：US20080132983A1

公开(公告)日：2008-06-05

申请号：US11978776

申请日：2007-10-29

申请人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

发明人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve, including a housing, configured to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve when the housing is placed in the vicinity of the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing such that the at least one electrode is between the end insulating elements, and the end insulating elements come in contact or practically in contact with the nerve when the housing is placed in the vicinity of the nerve. Other embodiments are also described.

摘要翻译： 提供了用于将电流施加到神经的装置，包括被配置为放置在神经附近的壳体。 至少一个电极被固定到壳体，使得当壳体放置在神经附近时，至少一个电极不会与神经直接物理接触，并且使得电极围绕大于180度的电极 放置外壳后神经的周长。 两个端部绝缘元件固定到壳体上，使得至少一个电极位于端部绝缘元件之间，并且当壳体放置在神经附近时，端部绝缘元件接触或实际上与神经接触。 还描述了其它实施例。

公开(公告)号：US20080091240A1

公开(公告)日：2008-04-17

申请号：US11975407

申请日：2007-10-19

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/3621

摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

摘要翻译： 提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏 脉冲和抗心律变能。 所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。 第一和第二控制单元不在一般控制之下。 控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。 还描述了其它实施例。

公开(公告)号：US07974693B2

公开(公告)日：2011-07-05

申请号：US11064446

申请日：2005-02-22

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/365

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3627

摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

摘要翻译： 提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏 脉冲和抗心律变能。 所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。 第一和第二控制单元不在一般控制之下。 控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。 还描述了其它实施例。