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![Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same](/abs-image/US/2014/06/03/US08741952B2/abs.jpg.150x150.jpg)
1.发明授权Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基 - 苯甲酸盐盐酸盐的多晶型物，其制备方法及其用途公开(公告)号：US08741952B2
公开(公告)日：2014-06-03
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： A01N37/12 , A01N37/44 , A61K31/24 , C07C229/00
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2014/08/21/US20140235728A1/abs.jpg.150x150.jpg)
2.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME 审中-公开4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用该方法公开(公告)号：US20140235728A1
公开(公告)日：2014-08-21
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C215/64 , C07C213/10
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2013/10/24/US20130281531A1/abs.jpg.150x150.jpg)
3.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用方法公开(公告)号：US20130281531A1
公开(公告)日：2013-10-24
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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公开(公告)号：US20170035856A1
公开(公告)日：2017-02-09
申请号：US15304528
申请日：2015-04-16
发明人： Tao Wang , Qilin Wang , Qianqian Xu , Lifang Sun , Ying Meng , Ju Li
CPC分类号： A61K38/26 , A61K9/16 , A61K9/1647 , A61K9/1682 , A61K38/22 , A61K47/34
摘要： An exenatide-containing composition is in the form of microspheres, which are prepared by using exenatide acetate and polylactic-co-glycolic acid (PLGA) as raw materials, and the content of acetic acid in the prepared composition is lower than 0.01%. A method for preparing the exenatide-containing microspheres includes selecting a cleaning fluid of a proper external water Phase and a proper amount to clean microspheres, and selecting a proper re-drying temperature to cure the after the microspheres are freeze dried.
摘要翻译： 含有艾塞那肽的组合物为微球形式，其通过使用醋酸艾塞那肽和聚乳酸共 - 乙醇酸（PLGA）作为原料制备，并且所制备组合物中乙酸的含量低于0.01％。 制备含有艾塞那肽的微球的方法包括选择适当的外部水相的清洗液和适量的清洁微球，并在微球冷冻干燥后选择适当的再干燥温度以固化。
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![Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same](/abs-image/US/2015/12/01/US09199912B2/abs.jpg.150x150.jpg)
5.发明授权Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基-4-甲基苯甲酸盐酸盐的多晶型物，其制备方法及其用途公开(公告)号：US09199912B2
公开(公告)日：2015-12-01
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： A61K31/235 , C07C213/10 , C07C215/20 , C07C215/64 , C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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公开(公告)号：US20180117123A1
公开(公告)日：2018-05-03
申请号：US15803807
申请日：2017-11-05
发明人： Tao Wang , Qilin Wang , Qianqian Xu , Lifang Sun , Ying Meng , Ju Li
CPC分类号： A61K38/26 , A61K9/16 , A61K9/1647 , A61K9/1682 , A61K38/22 , A61K47/34
摘要： An exenatide-containing composition is in the form of microspheres, which are prepared by using exenatide acetate and polylactic-co-glycolic acid (PLGA) as raw materials, and the content of acetic acid in the prepared composition is lower than 0.01%. A method for preparing the exenatide-containing microspheres includes selecting a cleaning fluid of a proper external water phase and a proper amount to clean microspheres, and selecting a proper re-drying temperature to cure the microspheres after the microspheres are freeze-dried.
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