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![Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same](/abs-image/US/2014/06/03/US08741952B2/abs.jpg.150x150.jpg)
1.发明授权Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基 - 苯甲酸盐盐酸盐的多晶型物，其制备方法及其用途公开(公告)号：US08741952B2
公开(公告)日：2014-06-03
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： A01N37/12 , A01N37/44 , A61K31/24 , C07C229/00
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2014/08/21/US20140235728A1/abs.jpg.150x150.jpg)
2.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME 审中-公开4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用该方法公开(公告)号：US20140235728A1
公开(公告)日：2014-08-21
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C215/64 , C07C213/10
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2013/10/24/US20130281531A1/abs.jpg.150x150.jpg)
3.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用方法公开(公告)号：US20130281531A1
公开(公告)日：2013-10-24
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same](/abs-image/US/2015/12/01/US09199912B2/abs.jpg.150x150.jpg)
4.发明授权Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基-4-甲基苯甲酸盐酸盐的多晶型物，其制备方法及其用途公开(公告)号：US09199912B2
公开(公告)日：2015-12-01
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： A61K31/235 , C07C213/10 , C07C215/20 , C07C215/64 , C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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公开(公告)号：US11111227B2
公开(公告)日：2021-09-07
申请号：US16860037
申请日：2020-04-27
发明人： Mina Yang , Yongtao Jiang , Ying Meng , Tao Wang , Qian qian Xu , Xin Shao , Chunjie Sha
IPC分类号： C07D333/10
摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.
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公开(公告)号：US10669249B2
公开(公告)日：2020-06-02
申请号：US16309807
申请日：2016-07-21
发明人： Mina Yang , Yongtao Jiang , Ying Meng , Tao Wang , Qian qian Xu , Xin Shao , Chunjie Sha
IPC分类号： C07D333/10
摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.
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