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![Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same](/abs-image/US/2014/06/03/US08741952B2/abs.jpg.150x150.jpg)
1.发明授权Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基 - 苯甲酸盐盐酸盐的多晶型物，其制备方法及其用途公开(公告)号：US08741952B2
公开(公告)日：2014-06-03
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： A01N37/12 , A01N37/44 , A61K31/24 , C07C229/00
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2014/08/21/US20140235728A1/abs.jpg.150x150.jpg)
2.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME 审中-公开4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用该方法公开(公告)号：US20140235728A1
公开(公告)日：2014-08-21
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C215/64 , C07C213/10
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2013/10/24/US20130281531A1/abs.jpg.150x150.jpg)
3.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用方法公开(公告)号：US20130281531A1
公开(公告)日：2013-10-24
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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公开(公告)号：US20180036246A1
公开(公告)日：2018-02-08
申请号：US15789091
申请日：2017-10-20
发明人： Wei Sun , Xuemei Zhang , Tao Wang , Guangyi Leng , Kaoxiang Sun , Youxin Li , Wanhui Liu
CPC分类号： A61K9/1647 , A61K9/1641 , A61K9/1682 , A61K9/1694 , A61K38/09
摘要： A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly (lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.
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公开(公告)号：US10258572B2
公开(公告)日：2019-04-16
申请号：US15789091
申请日：2017-10-20
发明人： Wei Sun , Xuemei Zhang , Tao Wang , Guangyi Leng , Kaoxiang Sun , Youxin Li , Wanhui Liu
摘要： A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly (lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.
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6.发明申请PHARMACEUTICAL COMPOSITIONS OF GOSERELIN SUSTAINED RELEASE MICROSPHERES 审中-公开GOSERELIN持续释放微生物的药物组合物公开(公告)号：US20160022584A1
公开(公告)日：2016-01-28
申请号：US14877976
申请日：2015-10-08
发明人： Wei Sun , Xuemei Zhang , Tao Wang , Guangyi Leng , Kaoxiang Sun , Youxin Li , Wanhui Liu
CPC分类号： A61K9/1647 , A61K9/1641 , A61K9/1682 , A61K9/1694 , A61K38/09
摘要： A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly(lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.
摘要翻译： 提供了戈舍瑞林缓释微球的组合物。 微球包括戈舍瑞林，至少一种聚（丙交酯 - 共 - 乙交酯）和泊洛沙姆或PEG。 缓释微球具有较高的生物利用度，促使药物充分发挥作用，并具有超过90％的捕获效率。
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![Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same](/abs-image/US/2015/12/01/US09199912B2/abs.jpg.150x150.jpg)
7.发明授权Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基-4-甲基苯甲酸盐酸盐的多晶型物，其制备方法及其用途公开(公告)号：US09199912B2
公开(公告)日：2015-12-01
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： A61K31/235 , C07C213/10 , C07C215/20 , C07C215/64 , C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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