公开(公告)号：US20220282231A1

公开(公告)日：2022-09-08

申请号：US17280636

申请日：2019-09-27

Applicant: SHANGHAI JIAO TONG UNIVERSITY ,  JECHO LABORATORIES, INC.

Inventor： Jianwei ZHU ,  Jing WANG ,  Lei HAN ,  Junsheng CHEN ,  Yueqing XIE ,  Hua JIANG

IPC: C12N9/14 ,  A61P35/00 ,  C07K14/21 ,  C12N15/11

Abstract: A polypeptide composition, and methods of making the same, may include a first polypeptide and a second polypeptide, wherein the first polypeptide comprise a first toxin fragment and a first intein fragment, the second polypeptide comprise a second toxin fragment and a second intein fragment, the first polypeptide is different from the second polypeptide; the first toxin fragment and the second toxin fragment are non-biotoxic; the first polypeptide and the second polypeptide may make the first toxin fragment and the second toxin fragment into biotoxic toxins by means of the interaction of the first intein fragment and the second intein fragment. Kits may include such first and second polypeptides, and such compositions and kits may be used in treating tumors.

公开(公告)号：US20220325286A1

公开(公告)日：2022-10-13

申请号：US17605472

申请日：2020-04-20

Applicant: SHANGHAI JIAO TONG UNIVERSITY ,  JECHO LABORATORIES, INC.

Inventor： Jianwei ZHU ,  Jing WANG ,  Junsheng CHEN ,  Yueqing XIE ,  Hua JIANG ,  Huifang ZONG ,  Lei HAN

IPC: C12N15/62 ,  C07K14/47 ,  C07K19/00 ,  C12N5/10 ,  C12P21/02

Abstract: Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

公开(公告)号：US20210255523A1

公开(公告)日：2021-08-19

申请号：US17170883

申请日：2021-02-08

Applicant: Shanghai Jiao Tong University

Inventor： Weiwen ZOU ,  Shaofu XU ,  Jing WANG

IPC: G02F7/00 ,  G02F1/03

Abstract: A monolithically integrated optical analog-to-digital conversion system based on a lithium niobate-silicon wafer, and a method for manufacturing the same, wherein a novel wafer (lithium niobate-silicon wafer) is used to implement the monolithically integrated optical analog-to-digital conversion system having multiple photonic devices, including an electro-optical modulator array, a tunable delay line array, an electronic circuit, and the like. As a result, multiple devices are manufactured on one chip, and the performance advantages and the stability of the system are guaranteed. Moreover, the present invention provides a CMOS-compatible method for manufacturing the system, so that the monolithically integrated optical analog-to-digital conversion system based on the lithium niobate-silicon wafer can be implemented on platforms of most chip manufacturers.

公开(公告)号：US20170133812A1

公开(公告)日：2017-05-11

申请号：US14954843

申请日：2015-11-30

Applicant: Shanghai Jiao Tong University

Inventor： Liejia QIAN ,  Jingui MA ,  Jing WANG ,  Peng YUAN ,  Guoqiang XIE

IPC: H01S3/00 ,  H01S3/109 ,  H01S3/13 ,  H01S3/23 ,  G02F1/37 ,  G02F1/355 ,  H01S3/11 ,  H01S3/16

CPC classification number: G02F1/39 ,  G02F1/3551 ,  G02F1/37 ,  G02F2001/392 ,  H01S3/0092 ,  H01S3/1611 ,  H01S3/1625 ,  H01S3/1636 ,  H01S3/1643 ,  H01S3/2316 ,  H01S3/2391

Abstract: Quasi-parametric chirped-pulse amplifier comprising a signal path, a pump path, and an amplifier. A dedicated nonlinear crystal doped with rare-earth-ions is used which has strong absorption around the idler waveband. Both the chirped signal pulse and the pump pulse incident into the amplifier, where energy continuously transfers from the pump pulse to the signal pulse and a newly generated idler pulse. The energy of the generated idler pulse is continually absorbed by the rare-earth ions doped in the amplifier.