公开(公告)号：US20230287107A1

公开(公告)日：2023-09-14

申请号：US17628869

申请日：2019-07-23

Applicant: ShanghaiTech University

Inventor： Guang YANG ,  Min QIANG

IPC: C07K16/28 ,  A61P9/10

CPC classification number: C07K16/28 ,  A61P9/10 ,  C07K2317/565 ,  C07K2317/52

Abstract: The present technology relates generally to compositions and methods of preventing or treating ischemic stroke. The present technology also relates to administering the anti-ASIC1a antibodies in effective amounts to treat a subject suffering from, or predisposed to, ischemic stroke.

公开(公告)号：US20230174642A1

公开(公告)日：2023-06-08

申请号：US17616492

申请日：2019-06-04

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Guang YANG ,  Min QIANG

IPC: C07K16/28 ,  G01N33/68 ,  A61P25/00

CPC classification number: C07K16/28 ,  G01N33/6872 ,  A61P25/00 ,  A61K2039/505

Abstract: Provided are immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that specifically bind acid-sensing ion channel 1a (ASIC1a) protein and uses of the same. Also provided is a method of administering an effective amount of the anti-ASIC1a antibodies to treat a subject suffering from, or predisposed to, acidosis, or to treat a subject suffering from a disease caused by or related to altered ASIC1a activity and/or signaling, including ischemic stroke and related conditions.